Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 285 - 303
Published: Jan. 1, 2024
Language: Английский
Neuroscience, Journal Year: 2024, Volume and Issue: 552, P. 126 - 141
Published: June 25, 2024
Language: Английский
Citations
4
BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)
Published: Jan. 1, 2024
Abstract Cancer is a significant disease that poses major threat to human health. Image-guided cancer therapy refers series of medical procedures use imaging technology precisely locate and treat cancer. Combining the dual characteristics images functional nanomaterial (NM) drug carriers, various integrated diagnosis treatment probes have been developed for in vivo dynamic monitoring therapeutic effect evaluation drugs based on imaging. Copper (Cu)-based NMs emerged as valuable products nanotechnology due their unique physicochemical properties, which are influenced by factors, such size, shape, surface properties. In field imaging, Cu-based offer combination desirable characteristics, including fluorescence emission, contrast enhancement, radiolabeling stability. These properties form foundation wide range modalities. addition, can be used carrier diagnostic or synergistic multiple modalities realized doping transition metals into heterostructures. become an important basis imaging-guided with NMs. this review we introduce biocompatible image-guided provide overview promising outcomes biomedical research.
Language: Английский
Citations
4
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 115 - 126
Published: Jan. 1, 2025
Abstract: Diabetic periodontitis is a common oral complication of diabetes characterized by progressive destruction periodontal tissues. Recent evidence suggests that mitochondrial dysfunction plays crucial role in the pathogenesis and progression this condition. This review aims to systematically summarize potential mechanisms diabetic periodontitis. We first explore relationship between dysfunction, then analyze specific manifestations periodontitis, including morphological changes, energy metabolism disorders, increased oxidative stress, enhanced apoptosis. further delve into connections pathogenic such as exacerbated inflammatory responses, decreased tissue repair capacity, autophagy dysregulation. Finally, we discuss therapeutic targets based on function, antioxidant strategies, mitochondria-targeted drugs, regulators. also propose future research directions, emphasizing need for in-depth exploration molecular mechanisms, development new diagnostic markers personalized treatment approaches. provides insights understanding offers theoretical basis developing targeted prevention strategies improve health patients. Keywords: inflammation,
Language: Английский
Citations
0
Arthritis Research & Therapy, Journal Year: 2025, Volume and Issue: 27(1)
Published: March 7, 2025
Osteoarthritis (OA) is the most common form of joint disease. Currently, OA treatment limited to controlling symptoms. Our previous study showed that stromal cell-derived factor 1 (SDF-1) delayed progression a certain extent. The aim this was explore specific mechanism SDF-1 in OA. chondrocytes and collagen-induced osteoarthritis (CIOA) mouse model were used as vitro vivo models, respectively. treat vivo. To treatment, we pretreated with Sirt 3 inhibitor assessed mitochondrial function then analysed related indicators cartilage anabolic metabolism. SOD2 PGC-1α levels significantly lower CIOA mice than normal chondrocytes, dysfunction occurred After treating exogenous SDF-1, abnormal biomarkers normalized. pretreatment or before exposure reversed these changes. can alleviate by resolving through activation Sirt3/PGC-1α signalling pathway, therefore, may be good candidate new for
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 10, 2025
Acute myocardial infarction (AMI) and the ischemia-reperfusion injury (MI/RI) that typically ensues represent a significant global health burden, accounting for considerable number of deaths disabilities. In context AMI, percutaneous coronary intervention (PCI) is preferred treatment option reducing acute ischemic damage to heart. Despite modernity PCI therapy, pathological cardiomyocytes due MI/RI remains an important target affects long-term prognosis patients. recent years, mitochondrial dysfunction during AMI has been increasingly recognized as critical factor in cardiomyocyte death. Damaged mitochondria play active role formation inflammatory environment by triggering key signaling pathways, including those mediated cyclic GMP-AMP synthase, NOD-like receptors Toll-like receptors. This review emphasizes dual both contributors regulators inflammation. The aim explore complex mechanisms its profound impact on immune dysregulation. Specific interventions mitochondrial-targeted antioxidants, membrane-stabilizing peptides, transplantation therapies have demonstrated efficacy preclinical models.
Language: Английский
Citations
0
Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 285 - 303
Published: Jan. 1, 2024
Language: Английский
Citations
0