Unraveling the mechanisms of glioblastoma’s resistance: investigating the influence of tumor suppressor p53 and non-coding RNAs DOI
Qamar A. Alshammari, Saud O. Alshammari, Abdullah S. Alshammari

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Language: Английский

Botox-A induced apoptosis and suppressed cell proliferation in fibroblasts pre-treated with breast cancer exosomes DOI Creative Commons

Hossein Sayaf,

Niloufar Salimian,

Mahnaz Mohammadi

et al.

Molecular and Cellular Probes, Journal Year: 2025, Volume and Issue: 79, P. 102007 - 102007

Published: Jan. 6, 2025

Language: Английский

Citations

2
Regulatory role of PPAR in colorectal cancer DOI Creative Commons
Cong Wang,

Tingcong Lv,

Binghui Jin

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 28, 2025

Language: Английский

Citations

1
Long non-coding RNAs: Emerging regulators of invasion and metastasis in pancreatic cancer DOI Creative Commons
Mengmeng Shi, Rui Zhang, Hui Lyu

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.

Language: Английский

Citations

1
Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential DOI Open Access

Helen Helen,

Mega Carensia Gunawan,

Princella Halim

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117347 - 117347

Published: Sept. 5, 2024

Language: Английский

Citations

4
Exosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis DOI Creative Commons
Xingliang Qin,

Rouxi Niu,

Yongyao Tan

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 14, 2024

Abstract Background It is well-established that understanding the mechanism of prostate cancer (PCa)-associated metastasis paramount for improving its prognosis. Metastasis known to involve communication between tumor-associated macrophages (TAMs) and tumor cells. Exosomes are crucial in mediating this intercellular within microenvironment. Nonetheless, role exosomal proteins PCa not yet fully understood. Here, we investigated mechanisms cancer-derived PSM-E on regulating macrophage M2 polarization suppress invasion metastasis. Methods levels exosomes were detected by transmission electron microscopy Western blotting analysis. The diagnostic value urine-derived evaluated LC-MS/MS, correlation analysis, ROC curves underlying inhibitory effect was co-IP, IHC staining, tumorigenesis model, etc. Results We revealed upregulated derived from serum urine patients. Clinically, an elevated expression significantly correlated with advanced pathological stage a high Gleason score. Our research also inhibits cell proliferation, invasion, suppressing vitro vivo. Furthermore, provided compelling evidence recruiting RACK1 FAK ERK signaling pathways, consequently found protease-associated domain fourth tryptophan-aspartate repeat interaction RACK1. Conclusions Notably, carrying could potentially serve as biomarker PCa, targeting may represent strategy preventing progression patient population.

Language: Английский

Citations

4
Role of lncRNA PVT1 in the progression of urological cancers: Novel insights into signaling pathways and clinical opportunities DOI
Mehrdad Hashemi,

Hamidreza Gholamrezaei,

Faezeh Ziyaei

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111736 - 111736

Published: March 1, 2025

Language: Английский

Citations

0
Immune prognostic model for glioblastoma based on the ssGSEA enrichment score DOI
Takanari Okamoto, Ryo Mizuta,

Ayako Demachi‐Okamura

et al.

Cancer Genetics, Journal Year: 2025, Volume and Issue: 294-295, P. 32 - 41

Published: March 22, 2025

Language: Английский

Citations

0
A Bioligical Perspective on the role of miR-206 in Colorectal cancer DOI
Mahsa Akbari Oryani,

Aseel Kamil Mohammad Al-Mosawi,

Hossein Javid

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149552 - 149552

Published: May 1, 2025

Language: Английский

Citations

0
Targeting ferroptosis for precision medicine in cervical cancer DOI
Xin Sun,

Z.K. Chen,

Hui Yang

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

Citations

0
The Immunomodulatory Effects of Vitamin D on COVID-19 Induced Glioblastoma Recurrence via the PI3K-AKT Signaling Pathway DOI Open Access

Bitian Zhang,

Ping‐Chung Leung, Chun Kwok Wong

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12952 - 12952

Published: Dec. 2, 2024

Glioma is a highly invasive brain cancer that difficult to treat due its complex molecular characteristics and poor prognosis. The COVID-19 pandemic has introduced additional clinical challenges for patients, especially those with glioma. This study explored the interactions between glioma using integrated bioinformatics methods, including enrichment analysis, survival docking, focusing on PI3K-Akt signaling pathway immunomodulatory role of vitamin D. From gene expression data COVID-19, 203 common differentially expressed genes were identified, six prognostic key genes-MYBL2, RBM6, VEPH1, AHNAK2, GNG10, DUSP14-were further determined. After intersecting D targets five determined-MYBL2, AHNAK2 GNG10. These play significant roles in potentially interact Molecular docking single-cell RNA sequencing analyses suggest may improve prognosis patients infected by regulating these pathway. findings reveal links thereby providing new insights developing targeted therapeutic strategies.

Language: Английский

Citations

2