Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(8), P. 1944 - 1944
Published: July 29, 2023
The
implementation
of
government
regulations
on
antibiotic
use,
along
with
the
public's
concern
for
drug
resistance,
has
strengthened
interest
in
developing
alternatives
not
only
aimed
at
preserving
animal
production
but
also
reducing
effects
pathogenic
infections.
Probiotics,
particular,
are
considered
microorganisms
that
induce
health
benefits
host
after
consumption
adequate
amounts;
they
have
been
established
as
a
potential
strategy
improving
growth,
especially
by
stimulating
intestinal
homeostasis.
Probiotics
commonly
associated
lactic
acid
bacteria,
and
Limosilactobacillus
fermentum
is
well-studied
species
recognized
its
favorable
characteristics,
including
adhesion
to
epithelial
cells,
antimicrobial
compounds,
activation
receptors
prompt
transcription
immune-associated
genes.
Recently,
this
used
production.
Different
studies
shown
application
L.
strains
improves
ecosystem
reduces
caused
potentially
microorganisms.
These
revealed
key
insights
into
mechanisms
behind
actions
exerted
probiotic.
In
manuscript,
we
aim
provide
concise
overview
administration
broiler
chicken
performance.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(3), P. 771 - 771
Published: March 17, 2023
Necrotic
enteritis
(NE)
is
an
economically
important
disease
of
chickens.
We
have
recently
shown
that
inflammatory
responses
in
chickens
inoculated
orally
with
virulent
Clostridium
perfringens
were
spatially
regulated.
Here,
we
used
previously
virulence-characterized
netB+
C.
strains,
avirulent
CP5
and
CP18
CP26,
to
assess
the
severity
NE
immune
broiler
when
intracloacally.
The
results
showed
CP18-
CP26-infected
birds
had
a
reduced
weight
gain
developed
milder/less
severe
lesions,
as
determined
by
gross
lesions
scores,
suggesting
subclinical-grade
infection.
Gene
expression
analysis
infected
revealed
three
statistically
significant
observations
compared
uninfected-control:
(1)
Increased
anti-inflammatory/immunoregulatory
interleukin
(IL)-10/transforming
growth
factor
(TGF)β
cecal
tonsil
(CT)
bursa
Fabricius
CP18/CP26-infected
groups.
(2)
CT
transcription
pro-inflammatory
IL-1β,
IL-6
interferon
(IFN)γ
decreased
Harderian
gland
(HG)
IFNγ
birds.
(3)
HG
or
bursal
IL-4
IL-13
CP5-infected
Collectively,
intracloacal
inoculation
seems
induce
highly
regulated
response
other
mucosal
lymphoid
organs
infection
model
may
be
useful
evaluating
subclinical
NE.
Animals,
Journal Year:
2023,
Volume and Issue:
13(23), P. 3643 - 3643
Published: Nov. 24, 2023
Necrotic
enteritis
is
a
devastating
disease
in
chickens
mainly
caused
by
Clostridium
perfringens—particularly,
Net-B
toxin-producing
strains.
In
order
to
combat
necrotic
broiler
production,
natural
growth
promoters,
as
well
anti-inflammatory
and
non-antibiotic
remedies,
were
developed
for
anti-microbial
resistance
due
its
status
global
pandemic.
Herein,
phytogenic
ginger,
wild
marjoram,
cloves
reviewed
potential
alternatives
antibiotics
their
functions.
These
phytogenics
contain
active
ingredients
that
efficiently
modulate
the
immune
response
improve
intestinal
morphology
overall
performance,
even
under
stress
infection
conditions.
Most
of
beneficial
effects
can
be
attributed
functions,
primarily
inhibition
NF-κB
MAPK
pathways.
Phytogenics
represent
substitutes
antibiotic
further
serving
remedies
treatment
birds
with
infections.
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: July 24, 2024
Necrotic
enteritis
(NE)
is
a
severe
gastrointestinal
disease
that
poses
significant
threat
to
the
poultry
industry.
It
leads
progressive
damage
small
intestine,
reduced
performance,
increased
mortality
rates,
and
substantial
economic
losses.
With
removal
of
antimicrobial
agents
from
chicken
feed,
there
an
urgent
need
find
alternative
approaches
for
NE
control.
Various
approaches,
including
vaccination,
prebiotics,
probiotics,
plant-derived
products,
have
been
utilized
address
in
management.
To
evaluate
efficacy
these
preventive
measures
against
NE,
successful
induction
crucial
observe
effects
related
studies.
This
study
presents
comprehensive
overview
methods
reproduction
studies
2004
2023.
These
considerations
are
careful
selection
virulent
