The cortisol switch between vulnerability and resilience

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(1), P. 20 - 34

Published: Jan. 4, 2023

Language: Английский

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Maternal personality, social support, and changes in depressive, anxiety, and stress symptoms during pregnancy and after delivery: A prospective-longitudinal study

PLoS ONE, Journal Year: 2020, Volume and Issue: 15(8), P. e0237609 - e0237609

Published: Aug. 24, 2020

Background The role of maternal personality and perceived social support for peripartum changes in psychopathological symptoms remains unresolved. Methods In a regional-epidemiological sample 306 women, depressive, anxiety, stress were assessed three times during pregnancy after delivery with the 21-item version Depression Anxiety Stress Scale. pregnancy, Big Five traits short Inventory Social Support Questionnaire. Results Multilevel analyses revealed that depressive (b = -0.055) -0.047) decreased from early to late pregnancy. After delivery, anxiety lower (two months postpartum: b -0.193; four/ 16 -0.274), but higher 0.468; 0.320) than Across period, more conscientious extraverted women experienced -0.147 -0.177), emotionally stable -0.294 -0.415). More strongly increased 0.019), less depression -0.010). Moreover, -0.225 -0.308). Conclusions Less stable, conscientious, seem be at risk might thus particularly profit targeted prevention.

Language: Английский

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Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy

Neurobiology of Stress, Journal Year: 2022, Volume and Issue: 18, P. 100455 - 100455

Published: April 23, 2022

'You can't roll the clock back and reverse effects of experiences' Bruce McEwen used to say when explaining how allostasis labels adaptive process. Here we will for once times that science glucocorticoid hormone was honored with a Nobel prize highlight discovery their receptors in hippocampus as inroad its current status master regulator control stress coping adaptation. Glucocorticoids operate concert numerous neurotransmitters, neuropeptides, other hormones aim facilitate processing information neurocircuitry stress, from anticipation perception novel experience behavioral adaptation memory storage. This action, exerted by glucocorticoids, is guided two complementary receptor systems, mineralocorticoid (MR) (GR), need be balanced healthy response pattern. discuss cellular, neuroendocrine, studies underlying MR:GR balance concept, relevance hypothalamic-pituitary-adrenal (HPA) -axis patterns note limited understanding yet sexual dimorphism actions. We conclude prospect (i) genetically epigenetically regulated variants dictate cell-type-specific transcriptome signatures stress-related neuropsychiatric symptoms (ii) selective modulators are becoming available more targeted treatment. These new developments may help 'restart clock' support resilience.

Language: Английский

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Brain mineralocorticoid receptor in health and disease: From molecular signalling to cognitive and emotional function

British Journal of Pharmacology, Journal Year: 2022, Volume and Issue: 179(13), P. 3205 - 3219

Published: March 17, 2022

Brain mineralocorticoid receptors (MR) mediate effects of glucocorticoid hormones in stress adaptation, as well the aldosterone itself relation to salt homeostasis. stem MRs respond aldosterone, whereas forebrain rapid and delayed conjunction with receptor (GR). MR‐mediated depend on age, gender, genetic variations, environmental influences. Disturbed MR activity through chronic stress, certain (endocrine) diseases or during therapy can cause deleterious affective state, cognitive behavioural function susceptible individuals. Considering important role plays cognition emotional health disease, modulation by pharmacological intervention could relieve stress‐ endocrine‐related symptoms. Here, we discuss recent interventions clinic developments molecular underpinnings signalling. Further understanding MR‐dependent pathways may help improve psychiatric symptoms a diversity settings. LINKED ARTICLES This article is part themed issue Emerging Fields for Therapeutic Targeting Aldosterone‐Mineralocorticoid Receptor Signaling Pathway. To view other articles this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.13/issuetoc

Language: Английский

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DNA methylation signature as a biomarker of major neuropsychiatric disorders

Journal of Psychiatric Research, Journal Year: 2021, Volume and Issue: 141, P. 34 - 49

Published: June 11, 2021

Language: Английский

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Antidepressant and anxiolytic potential of Citrus reticulata Blanco essential oil: a network pharmacology and animal model study

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 19, 2024

Background: Citrus reticulata Blanco essential oil (CBEO) has attracted increasing attention as a potential treatment for depression and anxiety in recent years. However, there is limited evidence regarding the active compounds responsible its therapeutic effects. In addition, substantial amounts of CBEO prolonged therapy are often required. This study aims to investigate rapid acting antidepressant anxiolytic effects CBEO, identify underlying composition well optimize dosage duration. Methods: was determined using gas chromatography–mass spectrometry (GC–MS), corresponding targets were obtained from SwissTargetPrediction database. Depression-related collected DisGeNET, GeneCards, Therapeutic Target Database, Online Mendelian Inheritance Man. Subsequently, overlap between utilized build network diagram depicting relationship ingredients Cytoscape software. The STRING database facilitated construction protein–protein interaction network, Ma’ayan Laboratory Enrichment tool employed Gene Ontology (GO) enrichment, Kyoto Encyclopedia Genes Genomes (KEGG), Wiki pathway analyses. Molecular docking conducted AutoDock Vina Discovery Studio Visualizer. Topological analysis predicted main CBEO. A mixture these prepared based on their relative GC–MS ratios. Tail suspension test, elevated plus maze, corticosterone-induced PC12 cells, lipopolysaccharide (LPS)-induced BV2 cells used validate CBEO’s bioactive constituents. Results: contains 18 components that target 121 proteins. We identified 595 associated with depression; among them, 29 located oils depression. results revealed linalool, p-cymene, α-terpinene, terpinen-4-ol, α-terpineol major management GO G protein-coupled opioid receptor activity, phospholipase C-activating receptor, neuron projections mostly related molecular functions, cellular components, biological processes. Neuroactive ligand-receptor interactions, chemical carcinogenesis, calcium signaling pathways KEGG analysis. showed had favorable binding affinities Protein-Protein Interaction’s hub proteins, including OPRM1, PTGS2, ESR1, SLC6A4, DRD2, NR3C1. These five then mixed at 0.8:5:0.6:2:1 (w/w) ratio form compound mixture. An acute intranasal (25 mg/kg) only demonstrated an effect, whereas combination (12.5 illustrated both mice. Linalool, terpinene-4-ol exhibited neuroprotective anti-neuroinflammation vitro study, while not observed α-terpinene α-terpineol. Conclusion: cymene might be mainly contributing effect by regulating neuroactive interaction, projection, pathway. via administration, which comparable also seen

Language: Английский

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Neurobiological and psychological factors to depression

International Journal of Psychiatry in Clinical Practice, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Aug. 5, 2024

Major Depressive Disorder (MDD) is a common condition with complex psychological and biological background. While its aetiology still unclear, chronic stress stands amongst major risk factors to MDD pathogenesis. When researching on MDD, it necessary be familiar the neurobiological effects of several prominent contributors factor experienced across hypothalamic-pituitary-adrenal (HPA) axis, neurotransmission, immune system reflexivity, genetic alterations. Bi-directional flow pathogenesis suggests that produce effects. Here, summary how expresses mechanisms action an overactive HPA negative impacts reduced neurotransmitter functions, inflammatory responses their gene x environment interactions. This paper builds these conceptual input towards symptomatology purpose synthesising current findings create integrated view Finally, relevant treatment implications will summarised, along recommendations multimodal clinical practice.

Language: Английский

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Prenatal Hypoxia Triggers a Glucocorticoid-Associated Depressive-like Phenotype in Adult Rats, Accompanied by Reduced Anxiety in Response to Stress

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5902 - 5902

Published: May 28, 2024

Fetal hypoxia and maternal stress frequently culminate in neuropsychiatric afflictions life. To replicate this condition, we employed a model of prenatal severe (PSH) during days 14-16 rat gestation. Subsequently, both control PSH rats at 3 months old were subjected to episodes inescapable induce learned helplessness (LH). The results the open field test revealed an inclination towards depressive-like behavior rats. Following LH episodes, (but not PSH) displayed significant anxiety. induced increase glucocorticoid receptor (GR) levels extrahypothalamic brain structures, with enhanced nuclear translocation hippocampus (HPC) observed However, only showed GR amygdala (AMG). decreased HPC correlated elevated hypothalamic corticotropin-releasing hormone (CRH) compared controls. resulted reduction CRH rats, aligning them those without affecting latter. This study presents evidence that leads associated alterations system. Notably, these impairments also contribute increased resistance stressors.

Language: Английский

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Early Life Stress Induced DNA Methylation of Monoamine Oxidases Leads to Depressive-Like Behavior

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 8, 2020

Major depressive disorder (MDD) is coming to be the regarded as one of leading causes for human disabilities. Due its complicated pathological process, etiology still unclear and treatment targeting at monoamine neurotransmitters. Early life stress has been known a major cause MDD, but how early affects adult monoaminergic activity not clear either. Recently, DNA methylation considered key mechanism epigenetics might play role in induced mental illness. an enzymatic covalent modification DNA, main epigenetic mechanisms investigated. The metabolic enzyme neurotransmitters, oxidases A/B (MAO A/MAO B) are prime candidates investigation into disorders. In this review, we will review recent advances about structure physiological function (MAO), brief narrative other factors include changes, stress, perinatal depression (PD) relationship with such methylation, microRNA (miRNA). This shed light on changes involved which may provide potential targets future therapeutics pathogenesis.

Language: Английский

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Glucocorticoid feedback paradox: a homage to Mary Dallman

Stress, Journal Year: 2023, Volume and Issue: 26(1)

Published: Jan. 2, 2023

As the end product of hypothalamus-pituitary-adrenal (HPA) axis, glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, adaptation to change. For this purpose, hormone promotes energy metabolism controls defense reactions in body brain. This life-sustaining action exerted by glucocorticoids occurs concert with autonomic nervous immune systems, transmitters, growth factors/cytokines, neuropeptides. The current contribution will focus on feedback paradox HPA-axis: phenomenon that stress responsivity remains resilient if preceded stress-induced secretion hormone, but not is previously administered. Furthermore, animal studies, mixed progesterone/glucocorticoid antagonist RU486 or mifepristone switches an apparent partial agonist upon repeated administration. To address these enigmas several interesting phenomena are highlighted. These include conditional nature excitation/inhibition balance regulation, role glucose as a determinant responsivity, potential resetting response system. analysis provides also golden opportunity review progress understanding resilience vulnerability during stress, science was burned deeply Mary Dallman's emotions.

Language: Английский

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