Fish Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 50(2), P. 827 - 842
Published: Dec. 27, 2023
Language: Английский
Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(1), P. 284 - 297
Published: Oct. 6, 2022
Abstract Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different levels point to high complexity numerous interrelated pathways as the underpinnings depression. systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, opioid system, myelination, gut-brain axis, among others. This review aims illustrating how these multiple signaling may interact provide more comprehensive view MDD’s neurobiology. In particular, considering pattern synaptic activity closest physical representation mood, emotion, conscience we can conceptualize, each pathway or system will be scrutinized for links neurotransmission. Models neurobiology MDD discussed well future actions improve understanding treatment options.
Language: Английский
Citations
232
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(1), P. 20 - 34
Published: Jan. 4, 2023
Language: Английский
Citations
84
Biochemistry (Moscow), Journal Year: 2023, Volume and Issue: 88(5), P. 565 - 589
Published: May 1, 2023
The review analyzes modern concepts about the control of various mechanisms hippocampal neuroplasticity in adult mammals and humans by glucocorticoids. Glucocorticoid hormones ensure coordinated functioning key components plasticity: neurogenesis, glutamatergic neurotransmission, microglia astrocytes, systems neurotrophic factors, neuroinflammation, proteases, metabolic hormones, neurosteroids. Regulatory are diverse; along with direct action glucocorticoids through their receptors, there conciliated glucocorticoid-dependent effects, as well numerous interactions between components. Despite fact that many connections this complex regulatory scheme have not yet been established, study factors considered work forms growth points field glucocorticoid-regulated processes brain primarily hippocampus. These studies fundamentally important for translation into clinic potential treatment/prevention common diseases emotional cognitive spheres respective comorbid conditions.
Language: Английский
Citations
34
Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(Suppl_1)
Published: March 7, 2024
ABSTRACT Exposure to stress during early life may alter the developmental trajectory of an animal by a mechanism known as adaptive plasticity. For example, enhance reproductive success in adverse environment, it is that animals accelerate their growth development. However, these short-term fitness benefits are often associated with reduced longevity, phenomenon rate–lifespan trade-off. In humans, exposure compromises health later and increases disease susceptibility. Glucocorticoids (GCs) major hormones implicated processes. This Review discusses evidence for GC-mediated plasticity development, leading allostatic overload life. We focus on GC-induced effects brain structure function, including neurogenesis; highlight need longitudinal studies; discuss approaches identify molecular mechanisms mediating alteration adult dysfunctions. Further understanding how GC can trajectories at cellular level critical importance reduce burden mental physical ill across course.
Language: Английский
Citations
8
Behavioral Sciences, Journal Year: 2022, Volume and Issue: 12(8), P. 262 - 262
Published: July 29, 2022
In modern society, there has been a rising trend of depression and anxiety. This heavily impacts the population's mental health thus contributes significantly to morbidity and, in worst case, suicides. Modern medicine, with many antidepressants anxiolytics at hand, is still unable achieve remission patients. The pathophysiology anxiety only marginally understood, which encouraged researchers focus on neuropeptides, as they are vast group signaling molecules nervous system. Neuropeptides involved regulation physiological functions. Some act neuromodulators often co-released neurotransmitters that allow for reciprocal communication between brain body. Most studied past were antidepressant anxiolytic effects oxytocin, vasopressin or neuropeptide Y S, Substance P. However, recent years, more novel neuropeptides have added list, implications research development new targets, diagnostic elements, even therapies treat depressive disorders. this review, we take close look all currently their related pathways, roles stress adaptation, etiology humans animal models. We will latest information regarding these associated picture potential uses future.
Language: Английский
Citations
37
Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 220 - 220
Published: Sept. 18, 2024
Chronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the response cortisol, glucocorticoid hormone produced by adrenal glands. While cortisol release adaptive in acute stress, prolonged exposure elevated levels can result adverse effects. This manuscript explores neurobiological of chronic its impact on metabolic dysregulation, particularly context inflammatory bowel diseases (IBDs). The hypothalamic-pituitary-adrenal (HPA) axis regulates production, which influences metabolism, immune response, neurobiology. Elevated are associated development exacerbation disorders like IBD contribute neurodegenerative processes, including cognitive impairments increased susceptibility psychiatric conditions. interaction between receptors, underscores complexity these review aims elucidate mechanisms through dysregulation health function, providing insights into potential therapeutic strategies mitigating
Language: Английский
Citations
6
Inhalation Toxicology, Journal Year: 2023, Volume and Issue: 35(3-4), P. 109 - 126
Published: Feb. 7, 2023
Air pollutants are being increasingly linked to extrapulmonary multi-organ effects. Specifically, recent studies associate air with brain disorders including psychiatric conditions, neuroinflammation and chronic diseases. Current evidence of the linkages between neuropsychiatric conditions peripheral immune metabolic diseases provides insights on potential role neuroendocrine system in mediating neural systemic effects inhaled (reactive particulates gases). Autonomically-driven stress responses, involving sympathetic-adrenal-medullary hypothalamus-pituitary-adrenal axes regulate cellular physiological processes through adrenal-derived hormones diverse receptor systems. Recent experimental demonstrates contribution very responding non-chemical stressors, reactive pollutants. The assessment how respiratory encounter induce lung responses system, impairment these pathways could be will improve understanding causes individual variations susceptibility habituation/learning resiliency. This review highlights pollution tract that impact autonomic sensory nervous triggering response, likely translocated nano particles or metal components, biological mediators released systemically causing remote tract. perspective use systems approaches incorporate multiple chemical environmental, psychosocial, interactive mechanisms networks emphasized.
Language: Английский
Citations
13
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105566 - 105566
Published: Feb. 2, 2024
Language: Английский
Citations
5
Encyclopedia, Journal Year: 2024, Volume and Issue: 4(2), P. 1026 - 1043
Published: June 20, 2024
The stress response is a natural physiological reaction of the organism, elicited to maintain internal environment and evoke adaptive behaviors, ultimately leading survival. However, at turn century, stress-related disorders gained increasing significance. aim entry explore fundamental question when system changes from beneficial detrimental system, contributing higher risk development and/or diseases. To develop context, here, we different concepts reveal complexities, perspectives, multiple relationships between neurochemistry, cerebral functional network, associated pathologies. According literature, affects nearly every biological through close interactions physiological, nervous, endocrine, immune systems faced with real or perceived threat. Considering today’s challenging times, where people are facing unavoidable adversities in their lives level uncertainty never before seen, this review emphasizes importance understanding potential consequences being unable cope stressful events. Susceptibility resilience have recognition as important areas study. literature presented here enhances our identifies causes various psychopathologies, mental health conditions, disabilities, even mortality that closely linked vulnerability stress. Experimental studies recent decades demonstrated many factors affecting ability stress, including differences individuals due genetic background, epigenetic regulation, gender, early-life experiences. Finally, there an urgent need change paradigm modern lifestyles strategy prevent spread “health epidemic 21st century”, which Therefore, acknowledge approaches enhance resilience, focusing on perception, tolerance, positive lifestyle behaviors.
Language: Английский
Citations
5
Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)
Published: April 11, 2023
Abstract Chromatin is the physical substrate of genome that carries DNA sequence and ensures its proper functions regulation in cell nucleus. While a lot known about dynamics chromatin during programmed cellular processes such as development, role experience-dependent remains not well defined. Accumulating evidence suggests brain cells, environmental stimuli can trigger long-lasting changes structure tri-dimensional (3D) organization influence future transcriptional programs. This review describes recent findings suggesting plays an important memory, particularly maintenance traces prior activity brain. Inspired by immune epithelial we discuss underlying mechanisms implications for health disease. We conclude presenting holistic view potential molecular integration assimilation information may constitute conceptual basis research.
Language: Английский
Citations
11