Trends in the Epidemiology of Pneumocystis Pneumonia in Immunocompromised Patients without HIV Infection

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(8), P. 812 - 812

Published: July 31, 2023

The increasing morbidity and mortality of life-threatening

Language: Английский

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Post-COVID-19 Fungal Infection in the Aged Population

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 555 - 555

Published: Feb. 27, 2023

Coronavirus disease 2019 (COVID-19) infection is currently a great cause of concern for the healthcare sector around globe. SARS-CoV-2 an RNA virus that causes serious associated with numerous adverse effects and multiple complications different organs systems during its pathogenic cycle in humans. Individuals affected by COVID-19, especially elderly populations immunocompromised people, are greatly vulnerable to opportunistic fungal pathogens. Aspergillosis, invasive candidiasis, mucormycosis widespread coinfections COVID-19 patients. Other infections rare but exhibiting increased incidence current scenario include caused Pneumocystis jirovecii, Histoplasma sp., Cryptococcus etc. By producing virulent spores, these pathogens increase severity morbidity fatality rates patients globally. These generally occur recovering from infection, resulting rehospitalization. Older individuals at higher risk developing infections. This review focuses on understanding prevalent patients, people. We have also highlighted important preventive methods, diagnostic approaches, prophylactic measures

Language: Английский

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Immune thrombocytopenic purpura secondary to COVID‐19 vaccination: A systematic review

European Journal Of Haematology, Journal Year: 2022, Volume and Issue: 110(4), P. 335 - 353

Published: Dec. 23, 2022

This systematic review aimed to retrieve patients diagnosed with de novo immune thrombocytopenic purpura (ITP) after COVID-19 immunization determine their epidemiological characteristics, clinical course, therapeutic strategies, and outcome.We conducted the using four major databases, comprising PubMed, Scopus, Web of Science, Cochrane library, until April 2022. A search was performed in duplicate access eligible articles English. Furthermore, a manual applied chosen papers' references enhance sensitivity. Data were extracted analyzed SPSS 20.1 software.A total 77 vaccine-associated ITP identified from 41 studies, including 31 case reports 10 series. The median age who developed 54 years (IQR 36-72 years). mRNA-based vaccines, BNT16B2b2 mRNA-1273, most implicated (75.4%). Those followed by adenovirus vector-based inclusive ChAdOx1 nCoV-19 vAd26.COV2.S. No report found relating other vaccines. Most cases (79.2%) first dose vaccination. 75% within 12 days vaccination, indicating shorter lag time compared routine childhood vaccinations. Sixty-seven (87%) hospitalized. management pattern similar primary ITP, systemic glucocorticoids, IVIg, or both basis treatment patients. achieved goals; only two individuals required secondary admission, one patient presented intracranial hemorrhage died complication.De is rare complication corresponding belong order frequency. frequency may be related scale administration individual vaccines potency inducing autoimmunity. more vaccine potent induce antigenic challenge, would be. had benign course responded typical treatments ITP.

Language: Английский

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Interesting Mucocutaneous Manifestations in COVID-19 Infection or Vaccination Confirmed by Histopathology: A Case Series

Case Reports in Dermatology, Journal Year: 2024, Volume and Issue: 16(1), P. 21 - 34

Published: Jan. 12, 2024

Mucocutaneous complications or adverse events due to SARS-CoV-2 infection vaccination have been well delineated in the literature, respectively. Most eruptions are considered mild and self-limiting; however, for atypical cases with a tentative clinical diagnosis, performing biopsy histopathological assessment is pivotal confirm diagnosis subsequently prescribe more tailored treatment. Despite diverse reporting of such incidents globally, most studies restrict rate biopsied less than 15%.

Language: Английский

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Constrictive pericarditis following inactivated virus COVID-19 vaccine: a case report with review of the literature

Radiology Case Reports, Journal Year: 2022, Volume and Issue: 17(10), P. 3774 - 3778

Published: Aug. 5, 2022

Cardiac adverse effects of the COVID-19 vaccine are very rare, myocarditis and pericarditis most common amid them, constrictive (CP) is reported to be restricted a few cases following mRNA vaccines. We report case 72-year-old male patient who developed symptoms right-sided heart failure, which started after 8 days receiving third dose inactivated virus his diagnostic tests comprising transthoracic echocardiography, chest CT scan, cardiac magnetic resonance were in favor CP. Ultimately, invasive catheterization confirmed diagnosis Due lack satisfactory response corticosteroid therapy, pericardiectomy was performed, gave rise symptom relief progressively substantially. Considering temporal course patient's exclusion other possible etiologies based on medical history evaluation, immunization with recognized as culprit for developing Despite being scarce phenomenon, could have tendency provoke pericardial inflammation so far causing Hence, physicians should high index suspicion these circumstances accelerate investigation.

Language: Английский

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COVID-19 in patients with classic and variant hairy cell leukemia

Blood Advances, Journal Year: 2023, Volume and Issue: 7(23), P. 7161 - 7168

Published: Sept. 20, 2023

Abstract Hairy cell leukemia (HCL), similar to its variant HCLv, is a B-cell malignancy associated with decreased humoral immunity. We prospectively monitored the largest cohort of patients HCL/HCLv date (n = 503) for COVID-19 by symptoms, antibody, and polymerase chain reaction (PCR) and/or antigen positivity. Fifty percent (253 (238 HCL 15 HCLv) had evidence COVID-19, 210 (83%) testing positive PCR or rapid-antigen test. Of 43 without tests, all nucleocapsid antibodies indicating exposure, 7 recalled no 36 mild symptoms. who tested positive, 23, 46, 129, 12 cases occurred in 2020, 2021, 2022, 2023, respectively. Among them, 175 began treatment 0.4 429 (median, 66) months before, 132 their last dose anti-CD20 monoclonal antibody 0.2 229 63) before. Two died, including young woman rituximab 2 after first-line cladribine before vaccine availability. Nearly recovered uneventfully from those vaccination significant immunosuppression recent treatment. However, normal B cells was lower spike levels as response (P .0094) longer recovery time .0036). Thus, large first determine relationships between outcome immune markers, mortality relatively low (∼1%), sequelae were uncommon, if The trials are registered at www.clinicaltrials.gov #NCT01087333 #NCT04362865.

Language: Английский

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Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(9)

Published: Sept. 1, 2023

Abstract Background Pulmonary thromboembolism (PTE) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which raises the COVID‐19 disease's fatality rate from 3% to 45%. Nevertheless, due fairly indistinguishable clinical symptoms and lack validated prediction models, PTE diagnosis in patients challenging. This study aims investigate applicability hematological indices predict incidence its severity SARS‐CoV‐2 patients. Methods A retrospective cohort was conducted on hospitalized with confirmed infection who underwent CT angiography assess probable them. The correlation between complete blood count parameters 1 day before outcomes, simplified pulmonary embolism index (s‐PESI) investigated. Results We discovered that among individuals PTE, males those higher platelet‐to‐lymphocyte (PLR) neutrophil‐to‐lymphocyte (NLR) ratios had greater likelihood ( p < .001, .027, .037, respectively). PLR significant independent predictor value .045. Moreover, neutrophil associated s‐PESI score developing : .038). Conclusions Among indices, NLR more precisely are cost‐effective simply calculable markers can assist physicians determining whether or not clinically require be employed as an indicator Further large multicenter prospective studies warranted corroborate these observations.

Language: Английский

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Development of a Scoring Method Based on a Chest CT Scan to Determine the Outcomes of COVID-19 Patients

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 19, 2023

Introduction As COVID-19 shifts from pandemic urgency to endemic management, healthcare systems are faced with the evolving challenge of providing optimized care and adept resource allocation in this landscape disease. However, timely management accurate assessment disease severity remains a cornerstone effective treatment. This study presents pioneering scoring system, based on primary chest CT scan findings, predict patient outcomes equip clinicians tool that can expedite decision-making. Method A retrospective cohort was conducted involving 406 confirmed cases referred two our hospitals Tehran, between February April 2020. Radiographic data were sourced imaging archive system evaluated by certified radiologist. We devised distinct scores for demographic factors, clinical indicators. These synthesized into comprehensive score forecast critical outcomes, such as mortality, ICU admission, intubation, or extended hospitalization. Of total cases, 161 (39.7%) classified severe, while 245 (60%) fell low moderate category. Results The mean demographic, scan, characteristics significantly higher those severe than non-severe group. cutoff predicting patients clinical, factors 2.5, 9.5, 8.5, respectively. Multivariate analysis indicated each unit increase these elevated odds fatal 24%, 2.8%, 12%, Then, using score, which is sum above scores, we further predicted severity. Conclusion findings suggest innovative initial serves robust predictor outcomes.

Language: Английский

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The course of patients with hairy cell leukemia during the omicron surge of the Covid‐19 pandemic

Hematological Oncology, Journal Year: 2023, Volume and Issue: 41(5), P. 894 - 903

Published: July 13, 2023

In this study, we aim to explore the outcomes of Covid-19 infection in patients with Hairy cell leukemia (HCL). The cohort is based on data obtained from electronic medical records. It includes 218 consecutive diagnosed HCL between 16 June 1998, and 20 September 2022, out which coronavirus has infected 85 during Omicron surge. Out who were by Covid-19; 7 (8.2%) have been hospitalized, mortality rate was 2.3% (two patients). Thirteen had previous waves, including 9/13 after vaccination, none them developed a severe disease. Humoral immune response three doses BNT162b2 mRNA vaccination regimen evaluated 40 attained 67.5%. Based multivariate analysis: unfavorable outcome significantly more common above 65 years old, at least one cytopenia, comorbidity cardiovascular disease or asplenia. Our results indicates that course COVID-19 wave improved relatively favorable.

Language: Английский

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Predictive value of haematological indices on incidence and severity of pulmonary embolism in COVID-19 patients

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

Background: Pulmonary thromboembolism (PTE) is a common complication of SARS-CoV-2, which raises the COVID-19 disease’s fatality rate from 3% to 45%. Nevertheless, due fairly indistinguishable clinical symptoms and lack validated prediction models, PTE diagnosis in patients challenging. This study aims investigate applicability hematological indices predict incidence its severity SARS-CoV-2 patients. Methods: A retrospective cohort was conducted on hospitalized with confirmed infection who underwent CT angiography assess probable them. The correlation between CBC parameters one day prior outcomes, simplified Embolism Severity Index (s-PESI) investigated. Results: We discovered that among individuals PTE, males those higher platelet-to-lymphocyte (PLR) neutrophil-to-lymphocyte (NLR) ratios had greater likelihood incidence. PLR significant independent predictor PTE. Moreover, neutrophil count associated s-PESI score developing Conclusions: Among haematological indices, NLR more precisely are cost-effective simply calculable markers can assist physicians determining whether or not clinically require be employed as an indicator Further large multicenter prospective studies warranted corroborate these observations.

Language: Английский

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