Malnutrition, nutrition support and dietary intervention: the role of the dietitian supporting patients with head and neck cancer DOI Creative Commons
Florence Cook, Jose Rodriguez,

Lorna McCaul

et al.

BDJ, Journal Year: 2022, Volume and Issue: 233(9), P. 757 - 764

Published: Nov. 11, 2022

Malnutrition is prevalent in patients with head and neck cancer (HNC) at diagnosis but can occur any stage of the treatment pathway. The impact disease burden side effects lead to altered anatomy, compromised quality quantity saliva impaired swallowing function, which result deleterious on nutritional status. Optimising nutrition status critical, as malnutrition adversely associated tolerance outcomes, wound healing, morbidity, mortality, life survival. Dietitians are integral members HNC multidisciplinary team uniquely qualified assessment, management optimisation across care This includes providing informational counselling carers short- long-term planned treatments alongside members. recommendation, provision monitoring support, be via oral, enteral or parenteral route. Oral support dietary counselling, nourishing dietary, food fortification advice high energy/protein oral supplements. Enteral tube feeding, required a and/or basis dietitians appropriate decision-making for type timing placement

Language: Английский

Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines☆ DOI Creative Commons
Jann Arends,

Florian Strasser,

Silvia Gonella

et al.

ESMO Open, Journal Year: 2021, Volume and Issue: 6(3), P. 100092 - 100092

Published: June 1, 2021

•This ESMO Clinical Practice Guideline provides key recommendations for managing cancer-related cachexia.•It covers screening, assessment and multimodal management of cancer cachexia.•All were compiled by a multidisciplinary group experts.•Recommendations are based on available scientific data the author's expert opinion.

Language: Английский

Citations

343
Cancer-associated cachexia — understanding the tumour macroenvironment and microenvironment to improve management DOI
Josep M. Argilés, Francisco J. López‐Soriano,

Britta Stemmler

et al.

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(4), P. 250 - 264

Published: Feb. 20, 2023

Language: Английский

Citations

116
Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy DOI Creative Commons
Emanuele Cereda, Annalisa Turri, Catherine Klersy

et al.

Cancer Medicine, Journal Year: 2019, Volume and Issue: 8(16), P. 6923 - 6932

Published: Sept. 30, 2019

Abstract In recent years, whey proteins (WP) have attracted increasing attention in health and disease for their bioactive functions. The aim of this study was to evaluate the benefit WP isolate (WPI) supplementation addition nutritional counseling malnourished advanced cancer patients undergoing chemotherapy (CT). a single‐center, randomized, pragmatic, parallel‐group controlled trial ( ClinicalTrials.gov : NCT02065726), 166 with mixed tumor entities candidate or CT were randomly assigned receive (N = 82) without 84) WPI (20 g/d) 3 months. primary endpoint change phase angle (PhA). Secondary endpoints included changes standardized PhA (SPA), fat‐free mass index (FFMI), body weight, muscle strength, toxicity (CTCAE 4.0 events). assessed (modified intention‐to‐treat population), plus 66) resulted improved compared alone 69): mean difference, 0.48° (95% CI, 0.05 0.90) P .027). also SPA .021), FFMI .041), weight .023), strength < .001), reduced risk (risk −9.8% [95% −16.9 −2.6]; .009), particularly severe (grade ≥ 3) events −30.4% −44.4 −16.5]; .001). CT, receiving counseling, 3‐month composition, toxicity. Further trials, aimed at verifying efficacy intervention on mid‐ long‐term clinical newly diagnosed specific types, are warranted.

Language: Английский

Citations

96
Inadequate Nutrition Coverage in Outpatient Cancer Centers: Results of a National Survey DOI Open Access
Elaine B. Trujillo,

Katrina Claghorn,

Suzanne Dixon

et al.

Journal of Oncology, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 8

Published: Nov. 22, 2019

Cancer-related malnutrition is associated with poor health outcomes, including decreased tolerance to cancer therapy, greater treatment toxicities, and increased mortality. Medical nutrition therapy (MNT) optimizes clinical yet registered dietitian nutritionists (RDNs), the healthcare professionals specifically trained in MNT, are not routinely employed outpatient centers where over 90% of all patients treated. The objective this study was evaluate RDN staffing patterns, services provided ambulatory oncology settings, screening practices, referral reimbursement practices across nation centers. An online questionnaire developed by Oncology Nutrition Dietetic Practice Group (ON DPG) Academy Dietetics distributed via ON DPG electronic mailing list. Complete data were summarized for 215 mean full-time equivalent (FTE) 1.7 ± 2.0. After stratifying type center, National Cancer Institute-Designated Centers (NCI CCs) a 3.1 3.0 FTEs compared 1.3 1.4 amongst non-NCI CCs. RDN-to-patient ratio, based on reported analytic cases, 1 : 2,308. Per day, RDNs evaluated counseled an average 7.4 4.3 patients. Approximately half (53.1%) screened malnutrition, 64.9% these facilities used validated tool. majority (76.8%) do bill services. This first national provider-to-patient ratios, These indicate there significant gap access need nutritional care.

Language: Английский

Citations

94
The IMPACT study: early loss of skeletal muscle mass in advanced pancreatic cancer patients DOI Creative Commons
Debora Basile,

A. Parnofiello,

Maria Grazia Vitale

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2019, Volume and Issue: 10(2), P. 368 - 377

Published: Feb. 4, 2019

Abstract Background Pancreatic cancer (PC) patients have multiple risk factors for sarcopenia and loss of skeletal muscle mass (LSMM), which may cause greater treatment toxicities, reduced response to therapy, prolonged hospitalization, impaired quality life, worse prognosis. Methods This is a retrospective study on advanced PC treated at the Department Oncology Udine, Italy, from January 2012 November 2017. Among 162 who received chemotherapy, 94 consecutive with an available computed tomography (CT) scan were retrospectively analyzed. The primary objective our was explore if early LSMM ≥ 10% (measured first radiological evaluation compared baseline) and/or baseline impact Baseline defined according Prado's criteria. Skeletal area measured as cross‐sectional areas (cm 2 ) using CT data through Picture archiving communication system (PACS) image system. Results In whole cohort, 48% ≤70 years old, 50% had metastatic disease. At baseline, 73% sarcopenia, 16% presented visceral fat 44 cm /m . Overall, 21% experienced 10%. Approximately 33% sarcopenic ~35% body index > 25 kg/m Of note, 71% evaluated by nutritionist, 56% dietary supplementation (oral parenteral). After median follow‐up 30.44 months, overall survival (OS) 11.28 whereas progression‐free (PFS) 5.72 months. By multivariate analysis, significantly associated OS [hazard ratio (HR): 2.16; 95% confidence interval (CI) 1.23–3.78; P = 0.007] PFS (HR: 2.31; CI 1.30–4.09; 0.004). Moreover, exploratory analysis showed that inflammatory indexes, such neutrophil–lymphocyte variation, (odds 1.31, 1.06–1.61, 0.010). Conclusions Early has negative prognostic role in patients. Further prospective investigations are needed confirm these preliminary data.

Language: Английский

Citations

68
Unmet needs in clinical nutrition in oncology: a multinational analysis of real-world evidence DOI Creative Commons
Riccardo Caccialanza, François Goldwasser,

Oliver Marschal

et al.

Therapeutic Advances in Medical Oncology, Journal Year: 2020, Volume and Issue: 12

Published: Jan. 1, 2020

Knowledge about cancer-related malnutrition and the use of clinical nutrition (CN) in real-world setting are lacking. We investigated diagnosis treatment frequency a multinational survey to identify unmet needs cancer patients' care.

Language: Английский

Citations

60
Exercise and Nutrition Interventions in Patients with Head and Neck Cancer during Curative Treatment: A Systematic Review and Meta-Analysis DOI Open Access
Asta Bye, Jon Arne Sandmæl, Guro B. Stene

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(11), P. 3233 - 3233

Published: Oct. 22, 2020

The aim of this meta-analysis was to examine the effects nutritional and physical exercise interventions combining these during radiotherapy treatment for patients with head neck cancer on body composition, objectively measured function status. Systematic electronic searches were conducted in MEDLINE (PubMed interface), EMBASE (Ovid CINAHL (EBSCO interface) Cochrane Library (Wiley interface). We identified 13 randomized controlled trials (RCTs) that included 858 patients. For using only nutrition as intervention, a significant difference between control group observed (SMD 0.42 (95CI 0.23–0.62), p < 0.001). Only pilot RCTs investigated combination no groups found 0.21 −0.16–0.58), = 0.259). function, better outcome 0.78 0.51–1.04), No status found. This significantly positive alone favor groups. studies combined observed. Future full-scaled is warranted.

Language: Английский

Citations

58
Examining guidelines and new evidence in oncology nutrition: a position paper on gaps and opportunities in multimodal approaches to improve patient care DOI Creative Commons
Carla M. Prado, Alessandro Laviano, Chelsia Gillis

et al.

Supportive Care in Cancer, Journal Year: 2021, Volume and Issue: 30(4), P. 3073 - 3083

Published: Nov. 23, 2021

Abstract Malnutrition, muscle loss, and cachexia are prevalent in cancer remain key challenges oncology today. These conditions frequently underrecognized undertreated have devastating consequences for patients. Early nutrition screening/assessment intervention associated with improved patient outcomes. As a multifaceted disease, requires multimodal care that integrates supportive interventions, specifically exercise, to improve nutrient intake, mass, physical functioning, quality of life, treatment An integrated team healthcare providers incorporates societies’ recommendations into clinical practice can help achieve the best possible A multidisciplinary panel experts oncology, nutrition, medicine participated 2-day virtual roundtable October 2020 discuss gaps opportunities alone combination relative current evidence international recommendations. The recommended five principles optimize practice: (1) position at center care; (2) partner colleagues administrators integrate process approach; (3) screen all patients malnutrition risk diagnosis regularly throughout treatment; (4) combine exercise interventions before (e.g., prehabilitation), during, after as standard status mass; (5) incorporate patient-centered approach care.

Language: Английский

Citations

53
Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults DOI
Christine Baldwin,

M.A. de van der Schueren,

Hinke Kruizenga

et al.

Cochrane library, Journal Year: 2021, Volume and Issue: 2021(12)

Published: Dec. 21, 2021

Language: Английский

Citations

46
Nutritional Support in Cancer patients: update of the Italian Intersociety Working Group practical recommendations DOI Creative Commons
Riccardo Caccialanza, Paolo Cotogni, Emanuele Cereda

et al.

Journal of Cancer, Journal Year: 2022, Volume and Issue: 13(9), P. 2705 - 2716

Published: Jan. 1, 2022

Malnutrition is a frequent problem in cancer patients, which leads to prolonged and repeated hospitalizations, increased treatment-related toxicity, reduced response treatment, impaired quality of life, worse overall prognosis the avoidable waste health care resources. Despite being perceived as limiting factor oncologic treatments by both oncologists there still considerable gap between need actual delivery nutrition care, attitudes vary considerably among professionals. In last 5 years, Italian Intersociety Working Group for Nutritional Support Cancer Patients (WG), has repeatedly revisited this issue concluded that some improvement nutritional Italy occurred, at least with regard awareness institutional activities. same period, new international guidelines management malnutrition cachexia have been released. these valuable initiatives, effective structural strategies concrete actions aimed facing challenging issues oncology are needed, requiring active participation scientific societies authorities. As continuation WG's work, we reviewed available data present literature from January 2016 September 2021, together most recent issued authorities, thus providing an update WG practical recommendations, suggestions areas/issues possible implementation.

Language: Английский

Citations

36