Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(3), P. 1146 - 1156
Published: March 27, 2024
Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes chemotherapy compliance. We examined to what extent registered cancer clinical trials record measures related symptoms of cachexia as outcomes, whether these were associated with trial characteristics.
Language: Английский
Journal of Clinical Oncology, Journal Year: 2023, Volume and Issue: 41(34), P. 5285 - 5295
Published: Sept. 1, 2023
Successful completion of chemotherapy is critical to improve breast cancer outcomes. Relative dose intensity (RDI), defined as the ratio delivered prescribed, a measure and associated with mortality. The effect exercise eating healthy diet on RDI unknown. We conducted randomized trial an nutrition intervention pathologic complete response (pCR) in women diagnosed initiating chemotherapy.
Language: Английский
Citations
48
Journal of Cancer, Journal Year: 2022, Volume and Issue: 13(9), P. 2705 - 2716
Published: Jan. 1, 2022
Malnutrition is a frequent problem in cancer patients, which leads to prolonged and repeated hospitalizations, increased treatment-related toxicity, reduced response treatment, impaired quality of life, worse overall prognosis the avoidable waste health care resources. Despite being perceived as limiting factor oncologic treatments by both oncologists there still considerable gap between need actual delivery nutrition care, attitudes vary considerably among professionals. In last 5 years, Italian Intersociety Working Group for Nutritional Support Cancer Patients (WG), has repeatedly revisited this issue concluded that some improvement nutritional Italy occurred, at least with regard awareness institutional activities. same period, new international guidelines management malnutrition cachexia have been released. these valuable initiatives, effective structural strategies concrete actions aimed facing challenging issues oncology are needed, requiring active participation scientific societies authorities. As continuation WG's work, we reviewed available data present literature from January 2016 September 2021, together most recent issued authorities, thus providing an update WG practical recommendations, suggestions areas/issues possible implementation.
Language: Английский
Citations
38
Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1150 - 1150
Published: May 23, 2024
Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) and antioxidants, contributes significantly to oral cancer such as squamous cell carcinoma (OSCC) initiation, promotion, progression. ROS, generated both internally externally, induce cellular damage including DNA mutations lipid peroxidation, fostering oncogene activation carcinogenesis. The objective of this review was cover analyze the interplay ROS influencing key processes proliferation, apoptosis, angiogenesis, shaping trajectory OSCC development. Despite promise antioxidants halt progression mitigate oxidative damage, their therapeutic efficacy remains debated. conducted literature search highlighted potential biomarkers that indicate levels showing for early detection monitoring OSCC. Furthermore, melatonin has emerged a promising adjunct therapy OSCC, exerting antioxidant oncostatic effects by modulating tumor-associated neutrophils inhibiting survival migration. In addition, aims shed light on developing personalized strategies patients with therapy, which will be discussed. Research is needed elucidate underlying mechanisms clinical implications stress modulation in context cancer.
Language: Английский
Citations
8
JNCI Journal of the National Cancer Institute, Journal Year: 2023, Volume and Issue: 115(8), P. 886 - 895
Published: May 22, 2023
Abstract Adequate nutrition is central to well-being and health can enhance recovery during illness. Although it well known that malnutrition, both undernutrition overnutrition, poses an added challenge for patients with cancer diagnoses, remains unclear when how intervene if such nutritional interventions improve clinical outcomes. In July 2022, the National Institutes of Health convened a workshop examine key questions, identify related knowledge gaps, provide recommendations advance understanding about effects interventions. Evidence presented at found substantial heterogeneity among published randomized trials, majority rated as low quality yielding mostly inconsistent results. Other research cited trials in limited populations showed potential reduce adverse associated malnutrition people cancer. After review relevant literature expert presentations, independent panel recommends baseline screening risk using validated instrument following diagnosis repeated after treatment monitor well-being. Those should be referred registered dietitians more in-depth assessment intervention. The emphasizes need further rigorous, well-defined intervention studies evaluate on symptoms cancer-specific outcomes intentional weight loss before or overweight obesity. Finally, although data effectiveness are needed first, robust collection recommended assess cost-effectiveness inform coverage implementation decisions.
Language: Английский
Citations
15
Advances in Nutrition, Journal Year: 2022, Volume and Issue: 13(6), P. 2420 - 2432
Published: June 22, 2022
Up to 70% of people with lung cancer may be affected by cancer-related malnutrition or muscle loss, depending on treatment modality and disease stage. This narrative review explores recent studies loss as well nutritional multimodal interventions treat these conditions in the context changing landscape cancer. Various types interventions, including individualized counseling, protein other specific nutrient supplementation, have been investigated. Overall, dietary increasing intake, supplementation omega-3 (n–3) fatty acids appear beneficial for some, albeit varying, patient outcomes. Multimodal generally a nutrition exercise component, show promising results; however, impact outcomes is mixed. A key finding this lack large, randomized trials guide intervention specifically Despite high prevalence known adverse outcomes, current evidence limited. targeted effort required improve quality population provide support clinicians deliver effective care.
Language: Английский
Citations
20
Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 121, P. 106021 - 106021
Published: Feb. 1, 2024
Language: Английский
Citations
4
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 24, 2024
Malnutrition is associated with higher rates of surgical complications, increased anticancer treatment toxicities, longer hospital stays, healthcare costs, poorer patient quality life, and lower survival rates. Nutritional support has been shown to improve all these outcomes. However, the nutritional care cancer patients still suboptimal several issues remain unresolved. Although effectiveness depends on timeliness intervention, assessment status often delayed perceived as unimportant. When diagnoses malnutrition are made, they rarely recorded in medical records. Hospitals lack staff dedicated clinical nutrition, making it difficult integrate into multidisciplinary management patients. Outside hospital, hampered by heterogeneous reimbursement policies a adequate community nutrition services. In addition, an increasing number turning potentially harmful "anti-cancer" diets trust medicine declines. Adopting mandatory screening, monitoring metrics, providing education providers, implementing telehealth systems some most urgent interventions that need be established future.
Language: Английский
Citations
4
Current Nutrition Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 15, 2024
Language: Английский
Citations
4
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 3, 2025
The problems related to nutrition generate great concern in palliative cancer patients and their caregivers. Literature has analyzed the psychological social that causes. From patient-centered orientation, there are protocols for nutritional care. This psycho-health information is a source of discomfort among families its absence generates many with negative clinical repercussions. Thus, this study aims analyze concept advanced care Furthermore, given food an important cultural component as it nutrition, sociocultural influence on representation will also be analyzed. design was qualitative cross-sectional recruitment period lasting 18 months. After informed consent, sample (N=57) caregivers were interviewed individually. data using content analysis descriptive analysis. existence statistical differences between groups (patients caregivers) tested by Chi-Square statistics. Results showed perception structured five categories: health/survival/life (e.g. "healthy"), relationship "intimate relationship"), "care role"), foodstuff "vegetables"), others ("anything"). There significant (p-Value>0.05) uses had higher scores. Then, perceived act and, therefore, expected strive eat despite loss appetite. one first explore emphasize insufficient consideration patients' caregivers' needs perceptions regarding food, well significance knowledge approaches. In way, could intervene understanding behavior concerning secondly, redirecting if harmful patient or family relationships health well-being
Language: Английский
Citations
0
Japanese Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Abstract Aims and Objectives The prognostic value of nutritional status in HR+/HER2- metastatic breast cancer (mBC) patients treated with CDK4/6 inhibitors (CDK4/6is) endocrine therapy (ET) is unclear. Methods/Materials effect PNI values before starting CDK 4/6i on patient prognosis was retrospectively analyzed. Results A total 431 were evaluated. After 35.7 months follow-up, the median overall survival (mOS) 46.3 (95% CI, 29.7–62.8). PNI-low group had decreased progression-free compared to PNI-high [16.6 vs. 30.5 months; univariate HR = 1.640, 95% confidence interval (CI): 1.281–2.099, P < .001]. group's mOS noticeably shorter than (35.0 not reached; multivariate-adjusted HR: 2.082, CI: 1.398–3.102, .001). When stratified by CDK4/6i line: In using as first line, mPFS for 24.6 35.6 (P .026), probabilities at 24, 36, 48 groups 75%, 62%, 57%, 88%, 80%, 72%, respectively .002). second line after, 8.2 vs.12.0 .014), 18.6 39.6 .001) group, respectively. ORR DCR significantly lower low-PNI high-PNI .018 .017, respectively). incidence grade 3–4 side effects due CDK4/6is (39.8% 30.7%, .046) greater group. Conclusions This study's results suggest that an easily measured reliable indicator mBC ET.
Language: Английский
Citations
0