Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(7), P. 499 - 515

Published: Feb. 21, 2022

Language: Английский

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Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(15), P. 5382 - 5382

Published: July 29, 2020

Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 IL-13 signatures. The correlates the downregulation of barrier-related molecules such as filaggrin (FLG), loricrin (LOR), involucrin (IVL). IL-4 potently inhibit expression these by activating signal transducer activator transcription (STAT)6 STAT3. In addition to IL-13, IL-22 IL-17A are probably involved in inhibiting molecules. contrast, natural or medicinal ligands for aryl hydrocarbon receptor (AHR) potent upregulators FLG, LOR, IVL expression. As IL-4, IL-22, all capable inducing oxidative stress, antioxidative AHR agonists coal tar, glyteer, tapinarof exert particular therapeutic efficacy AD. These known activate factor, nuclear factor E2-related 2 (NRF2). This article focuses on mechanisms which regulated IL-17A. author also summarizes how NRF2 dual activators their beneficial effects treatment

Language: Английский

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Molecular mechanisms of oxidative stress in asthma

Molecular Aspects of Medicine, Journal Year: 2021, Volume and Issue: 85, P. 101026 - 101026

Published: Oct. 7, 2021

Language: Английский

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New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 13, 2021

The interaction between host and microorganism widely affects the immune metabolic status. Indole its derivatives are metabolites produced by metabolism of tryptophan catalyzed intestinal microorganisms. By activating nuclear receptors, regulating hormones, affecting biological effects bacteria as signaling molecules, indole maintain homeostasis impact liver response, which shows good therapeutic prospects. We reviewed recent studies on derivatives, including related metabolism, influence diets commensal bacteria, targets mechanisms in pathological conditions, especially progress strategies. New research insights into indoles will facilitate a better understanding their druggability application diseases.

Language: Английский

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Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation

Cellular and Molecular Life Sciences, Journal Year: 2020, Volume and Issue: 78(3), P. 909 - 922

Published: Sept. 23, 2020

Language: Английский

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Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases

Gut, Journal Year: 2022, Volume and Issue: 72(7), P. 1296 - 1307

Published: Oct. 21, 2022

The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp end-products are essential intestinal homeostasis. Here, we investigated role metabolites from kynurenine pathway.Targeted quantitative metabolomics was performed in two large human IBD cohorts (1069 patients with IBD). Dextran sodium sulphate-induced colitis experiments mice were used evaluate effects identified metabolites. In vitro, ex vivo and decipher mechanisms involved. Effects on energy evaluated by different methods including Single Cell mEtabolism profiling Translation inHibition.In humans, inflammation severity negatively correlates amount xanthurenic (XANA) kynurenic (KYNA) acids. Supplementation XANA KYNA decreases through epithelial cells T cells, involving Aryl hydrocarbon Receptor (AhR) activation rewiring cellular metabolism. Furthermore, direct modulation endogenous metabolism, using recombinant enzyme aminoadipate aminotransferase (AADAT), responsible for generation KYNA, protective rodent models.Our study a new mechanism linking IBD. Bringing back has AhR CD4+ cells. This paves way therapeutic strategies aiming at pharmacologically correcting its manipulating metabolic pathway AADAT.

Language: Английский

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Fundamentals of redox regulation in biology

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(9), P. 701 - 719

Published: April 30, 2024

Language: Английский

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A Systematic Review of Polycyclic Aromatic Hydrocarbon Derivatives: Occurrences, Levels, Biotransformation, Exposure Biomarkers, and Toxicity

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(41), P. 15314 - 15335

Published: Sept. 13, 2023

Polycyclic aromatic hydrocarbon (PAH) derivatives constitute a significant class of emerging contaminants that have been ubiquitously detected in diverse environmental matrixes, with some even exhibiting higher toxicities than their corresponding parent PAHs. To date, compared PAHs, fewer systematic summaries and reanalyses are available for PAH great concerns. This review summarizes the current knowledge on chemical species, levels, biotransformation patterns, analytical methods, internal exposure routes representative biomarkers, toxicity derivatives, primarily focusing nitrated PAHs (NPAHs), oxygenated (OPAHs), halogenated (XPAHs), alkylated (APAHs). A collection 188 compounds from four categories, 44 NPAHs, 36 OPAHs, 56 APAHs, 52 XPAHs, has compiled 114 studies documented presence derivatives. These exhibited weighted average air concentrations varied lower limit 0.019 pg/m3 to threshold 4060 pg/m3. Different methods utilizing comprehensive two-dimensional gas chromatography coupled high-resolution time-of-flight mass spectrometry (GC × GC-TOF-MS), (GC-TOF-MS), quadrupole GC-QQQ-MS), Fourier-transform ion cyclotron resonance (FT-ICR MS), adopted untargeted strategies identification also reviewed here. Additionally, an in-depth analysis patterns each category is provided, including likelihood specific reaction types. For toxicity, we summarized key metabolic activation pathways, which could result formation reactive metabolites capable covalently bonding DNA tissue proteins, potential health outcomes such as carcinogenicity genotoxicity, oxidative stress, inflammation immunotoxicity, developmental might be mediated by aryl receptor (AhR). Finally, pinpoint research challenges emphasize need further identifying tracking external evaluating levels associated clarifying routes, considering mixture effects. aims provide broad understanding derivatives' identification, occurrence, human exposure, biotransformation, offering valuable reference guiding future this underexplored area.

Language: Английский

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Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 208, P. 115371 - 115371

Published: Dec. 15, 2022

Language: Английский

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Environmental impact and human health effects of polycyclic aromatic hydrocarbons and remedial strategies: A detailed review

Chemosphere, Journal Year: 2024, Volume and Issue: 351, P. 141227 - 141227

Published: Jan. 21, 2024

Language: Английский

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