miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma DOI Creative Commons

José Daniel Escobar Moreno,

José Luis Fajardo Castiblanco,

Laura Camila Riaño Rodriguez

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1326 - 1326

Published: Oct. 30, 2024

Reactive oxygen species (ROS) are intermediates in oxidation-reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological pathophysiological conditions where there is an imbalance between oxidative factors antioxidant response of organism, a phenomenon known as stress. Evidence suggests that differential modulation ROS-mediated stress occurs pathogenesis progression melanoma, this redox homeostasis appears be functionally linked microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes transcription factors. The relationship control, tumour microenvironment, miRNA expression melanoma not fully understood. aim review analyse involvement miRNAs involved melanoma. It hoped these considerations will contribute understanding mechanisms associated potential network regulation, consolidated common factor therefore, footprint poorly documented.

Language: Английский

Non-Thermal Plasma Application in Medicine—Focus on Reactive Species Involvement DOI Open Access

Julia Moszczyńska,

Katarzyna Roszek, Marek Wiśniewski

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12667 - 12667

Published: Aug. 11, 2023

Non-thermal plasma (NTP) application in medicine is a dynamically developing interdisciplinary field. Despite the fact that basics of phenomenon have been known since 19th century, growing scientific attention has paid recent years to use medicine. Three most important plasma-based effects are pivotal for medical applications: (i) inactivation broad spectrum microorganisms, (ii) stimulation cell proliferation and angiogenesis with lower treatment intensity, (iii) cells by initialization death higher intensity. In this review, we explain underlying chemical processes reactive species involvement during NTP human (or animal) tissues, as well bacteria inactivation, which leads sterilization indirectly supports wound healing. addition, plasma-mediated modifications surfaces, such surgical instruments or implants, described. This review focuses on existing knowledge NTP-based vitro vivo studies highlights potential opportunities development novel therapeutic methods. A full understanding mechanisms action urgently needed further modern

Language: Английский

Citations

31
Synergistic effects of cold atmospheric plasma and doxorubicin on melanoma: A systematic review and meta-analysis DOI Creative Commons
Zeinab Rostami, Reza Alizadeh‐Navaei,

Monireh Golpoor

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 6, 2025

Melanoma is responsible for the majority of skin cancer deaths, but there are ways to combat this deadly disease. One method using anti-neoplastic agents, such as Doxorubicin (DOX). Unfortunately, DOX can be toxic and may lead drug resistance. However, researchers excited about potential Cold Atmospheric Plasma (CAP) treatment cells overcome resistance selectively. To better understand effectiveness combination CAP on melanoma cell viability, cytotoxicity, death, we conducted a comprehensive evaluation meta-analysis in study. 41 studies out 121 met our inclusion criteria. The pooled analysis found that had significant effect viability (ES = 6.75, 95% CI 1.65 11.85, I2 71%) cytotoxicity 11.71, 3.69 19.73, 56%). however, no statistically association was between death with treatment. Our have confirmed combined has synergistic reducing increasing cells. These results assist selecting more effective methods address melanoma.

Language: Английский

Citations

1
Artemisia capillaris Thunb. Polysaccharide alleviates cholestatic liver injury through gut microbiota modulation and Nrf2 signaling pathway activation in mice DOI
Jingyi Cai,

Zhenyun Zhu,

Yuanyuan Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 327, P. 118009 - 118009

Published: March 4, 2024

Language: Английский

Citations

8
Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production DOI
Xianqi Zhang, Mengdi Zhang, Ziyan Zhang

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 438(1), P. 114034 - 114034

Published: April 6, 2024

Language: Английский

Citations

7
Structural Analysis of Plasma‐Induced Oxidation and Electric Field Effect on the Heat Shock Protein (Hsp60) Structure: A Computational Viewpoint DOI Open Access
Pankaj Attri, Takamasa Okumura, Kazunori Koga

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

ABSTRACT In recent years, there has been an increase in the study of mechanisms behind plasma oncology. For this, many wet lab experiments and computational studies were conducted. Computational give advantage examining protein structures that are costly to extract enough amounts analyze biophysical properties following treatment. Therefore, this work, we studied effect oxidation electric field on human mitochondrial heat shock (mHsp60). Hsp60, alias chaperonin, is one most conserved proteins expressed across all species. Hence, performed molecular dynamic simulations calculate root‐mean‐square deviation, fluctuation, solvent‐accessible surface area mHsp60 with without oxidation. addition state, also applied (0.003 2.0 V/nm) check changes protein. Through simulations, observed strongly affects structure compared The combination increases destabilization their respective control states.

Language: Английский

Citations

0
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response DOI Creative Commons
Joey De Backer,

Darko Maric,

Karim Zuhra

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1548 - 1548

Published: Aug. 10, 2022

Despite recent advances in melanoma treatment, there are still patients that either do not respond or develop resistance. This unresponsiveness and/or acquired resistance to therapy could be explained by the fact some cells reside a dedifferentiated state. Interestingly, this state is associated with greater sensitivity ferroptosis, lipid peroxidation-reliant, iron-dependent form of cell death. Cytoglobin (CYGB) an iron hexacoordinated globin highly enriched melanocytes and frequently downregulated during melanomagenesis. In study, we investigated potential effect CYGB on cellular towards (1S, 3R)-RAS-selective lethal small molecule (RSL3)-mediated ferroptosis G361 abundant endogenous expression. Our findings show increased basal ROS level higher degree peroxidation upon RSL3 treatment contribute knockdown ferroptosis. Furthermore, transcriptome analysis demonstrates enrichment multiple cancer malignancy pathways knockdown, supporting tumor-suppressive role for CYGB. Remarkably, also triggers activation NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) inflammasome subsequent induction pyroptosis target genes. Altogether, silencing expression modulates via regulation death signaling pathways.

Language: Английский

Citations

17
Unveiling intricating roles and mechanisms of ferroptosis in melanoma DOI
Tao Rui,

Yichuan Li,

Song Gong

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1880(1), P. 189234 - 189234

Published: Dec. 5, 2024

Language: Английский

Citations

3
Mechanism of Non-thermal Atmospheric Plasma in Anti-Tumor: Influencing Intracellular RONS and Regulating Signaling Pathways DOI
Wenjie Wang,

Peijia Zheng,

Liang Yan

et al.

Free Radical Research, Journal Year: 2024, Volume and Issue: 58(5), P. 333 - 353

Published: May 3, 2024

Non-thermal atmospheric plasma (NTAP) has been proven to be an effective anti-tumor tool, with various biological effects such as inhibiting tumor proliferation, metastasis, and promoting cell apoptosis. At present, the main conclusion is that ROS RNS are effector components of NTAP, but mechanisms which still lack systematic summary. Therefore, in this review, we first summarized mechanism by NTAP directly or indirectly causes increase intracellular RONS concentration, multiple pathways dysregulation (i.e., NRF2, PI3K, MAPK, NF-κB) induced RONS. Then, generalized relationship between it brought. The summary helpful for its further research clinical transformation.

Language: Английский

Citations

2
Non-thermal atmospheric pressure plasma induces selective cancer cell apoptosis by modulating redox homeostasis DOI Creative Commons

Ju Hyun Yun,

Yoon Hee Yang,

Chang Hak Han

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 26, 2024

Language: Английский

Citations

2
Insights into the function of cytoglobin DOI Creative Commons
Brandon J. Reeder

Biochemical Society Transactions, Journal Year: 2023, Volume and Issue: 51(5), P. 1907 - 1919

Published: Sept. 18, 2023

Since its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive vitro and vivo research, a range potential physiological pathological mechanisms emerged for this multifunctional member hemoglobin family. Currently, over 200 research publications have examined different aspects structure, redox chemistry roles cell signalling pathways. This is wide ranging, but common themes throughout research. review examines current structural, biochemical knowledge published past two decades. Radical scavenging, nitric oxide homeostasis, lipid binding oxidation role an intramolecular disulfide bond on are examined, together with Cygb cancer progression liver fibrosis.

Language: Английский

Citations

6