Fasudil attenuates oxidative stress-induced partial epithelial-mesenchymal transition of tubular epithelial cells in hyperuricemic nephropathy via activating Nrf2 DOI Creative Commons

Yun Cao,

Yanni Wang, Weiwei Li

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176640 - 176640

Published: May 14, 2024

Anti-partial epithelial-mesenchymal transition (pEMT) treatment of renal tubular epithelial cells (TECs) represents a promising therapeutic approach. Hyperuricemia nephropathy (HN) arises as consequence hyperuricemia (HUA)-induced tubulointerstitial fibrosis (TIF). Studies have suggested that the Ras homolog member A (RhoA)/Rho-associated kinase (ROCK) pathway is crucial signaling transduction system in fibrosis. Fasudil, RhoA/ROCK inhibitor, has exhibited potential to prevent progress. However, its impact on pEMT TECs HN remains unclear. Here, an rat model and uric acid (UA)-stimulated human kidney 2 (HK2) cell were established treated with Fasudil explore effects. Furthermore, underlying mechanism action involved attenuation by during was probed using multiple molecular approaches. The significant dysfunction histopathological damage, whereas vitro vivo experiments further confirmed status accompanied activation oxidative stress exposed UA. Notably, ameliorated these pathological changes, this consistent trend ROCK silencing vitro. Mechanistically, we identified Neh2 domain nuclear factor erythroid 2-related (Nrf2) target for first time. targets Nrf2 antagonizes attenuate HN. Our findings suggest attenuates stress-induced targeting activation. Thus, agent

Language: Английский

Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways DOI Open Access
Halyna Tkachenko, Natalia Kurhaluk

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1098 - 1098

Published: Jan. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Language: Английский

Citations

4
EGCG Improve Meat Quality, Restore Lipid Metabolism Disorder and Regulate Intestinal Flora in High-fat Fed Broilers DOI Creative Commons
Lihua Gao, Chen Liu, Jiaqi Wu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104875 - 104875

Published: Feb. 2, 2025

Language: Английский

Citations

3
Nrf2: a dark horse in doxorubicin-induced cardiotoxicity DOI Creative Commons
Xiaopeng Zhao,

Zheng Tian,

Mingli Sun

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 26, 2023

Abstract Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be formidable obstacle. Numerous studies are currently devoted elucidating the pathological mechanisms underlying doxorubicin-induced cardiotoxicity. Nrf2 has always played crucial role in oxidative stress, but numerous demonstrated that it also plays vital part like cell death and inflammation. on associated with cardiotoxicity demonstrate this. Several drugs, natural synthetic compounds, as well small molecule RNAs been prevent by activating Nrf2. Consequently, this study emphasizes introduction of Nrf2, discusses cardiotoxicity, concludes summary therapeutic modalities targeting ameliorate highlighting potential value

Language: Английский

Citations

43
The Nrf2 Pathway in Depressive Disorders: A Systematic Review of Animal and Human Studies DOI Creative Commons
Gabriele Sani, Stella Margoni, Andrea Brugnami

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 817 - 817

Published: March 27, 2023

There is increasing interest in the involvement of antioxidative systems protecting from depression. Among these, Nrf2 occupies a central place. We aimed to review role For this reason, we conducted PubMed search using as strategy (psychiatr*[ti] OR schizo*[ti] psychot*[ti] psychos*[ti] depress*[ti] MDD[ti] BD[ti] bipolar[ti] Anxiety[ti] antidepress*[ti] panic[ti] obsess*[ti] compulsio*[ti] “mood disord*”[ti] phobi*[ti] agoraphob*[ti] anorex*[ti] anorect*[ti] bulimi*[ti] “eating disorder*”[ti] neurodevelopm*[ti] retardation[ti] autism[ti] autistic[ti] ASM[ti] adhd[ti] “attention-deficit”[ti]) AND nrf2, which on 9th March produced 208 results 89 were eligible for our purposes. Eligible articles studies reporting data manipulations or content by any treatment human patients animals with animal model Most mice only (N = 58), 20 rats only, and three both mice. two cell lines (in vitro) one each nematodes fish. Only four humans, was post mortem. male animals; however, carried out men women. The indicate that lower depression antidepressant methods (drugs other methods) increase it. Antioxidant plasticity-promoting molecules, such those Nrf2–HO-1, BDNF–TrkB, cyclic AMP–CREB pathways, could protect depression, while glycogen synthase kinase-3β nuclear factor κB oppose these actions, thus depressive-like behaviours. Since also endowed tumorigenic atherogenic potential, balance between benefits harms must be taken into account designing novel drugs aiming at intracellular Nrf2.

Language: Английский

Citations

24
Ferroptosis: a new antidepressant pharmacological mechanism DOI Creative Commons
Guangheng Zhang, Shimeng Lv, Xia Zhong

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The incidence rate of depression, a mental disorder, is steadily increasing and has the potential to become major global disability factor. Given complex pathological mechanisms involved in use conventional antidepressants may lead severe complications due their side effects. Hence, there critical need explore development novel antidepressants. Ferroptosis, newly recognized form cell death, been found be closely linked onset depression. Several studies have indicated that certain active ingredients can ameliorate depression by modulating ferroptosis signaling pathway. Notably, traditional Chinese medicine (TCM) TCM prescriptions demonstrated promising antidepressant effects previous investigations owing unique advantages therapy. Building upon these findings, our objective was review recent relevant research provide new insights directions for application innovative strategies.

Language: Английский

Citations

14
Hypoglycemic effects of edible fungus polysaccharides: A mini review DOI

Yan-Long Cui,

Бо Лі

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(1), P. 9420046 - 9420046

Published: Sept. 28, 2024

Language: Английский

Citations

12
Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation DOI
Zhou Yang, Ya‐Lin Zhao, Yanling Wang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155433 - 155433

Published: Feb. 7, 2024

Language: Английский

Citations

10
A review of the pharmacological action and mechanism of natural plant polysaccharides in depression DOI Creative Commons
Yuhe Yang,

Chen-Xue Li,

Ruobing Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Depression is a prevalent mental disorder. However, clinical treatment options primarily based on chemical drugs have demonstrated varying degrees of adverse reactions and drug resistance, including somnolence, nausea, cognitive impairment. Therefore, the development novel antidepressant medications that effectively reduce suffering side effects has become prominent area research. Polysaccharides are bioactive compounds extracted from natural plants possess diverse pharmacological activities medicinal values. It been discovered polysaccharides can mitigate depression symptoms. This paper provides an overview action mechanisms, intervention approaches, experimental models regarding derived various sources. Additionally, we summarize roles potential mechanisms through which these prevent by regulating neurotransmitters, HPA axis, neurotrophic factors, neuroinflammation, oxidative stress, tryptophan metabolism, gut microbiota. Natural plant hold promise as adjunctive antidepressants for prevention, reduction, exerting their therapeutic multiple pathways targets. this review aims to provide scientific evidence developing polysaccharide resources effective drugs.

Language: Английский

Citations

10
Nrf2 pathways in neuroprotection: Alleviating mitochondrial dysfunction and cognitive impairment in aging DOI
Asif Ahmad Bhat, Ehssan Moglad, Ahsas Goyal

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123056 - 123056

Published: Sept. 12, 2024

Language: Английский

Citations

10
Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants DOI Creative Commons

Yanru Long,

Houhui Shi,

Jiatian Ye

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 114 - 114

Published: Jan. 20, 2025

Oxidative stress is a state of imbalance between the production reactive oxygen species (ROS) and nitrogen (RNS) antioxidant defence system in body. may be associated with variety diseases, such as ovarian cancer, diabetes mellitus, neurodegeneration. The generation oxidative one common refractory malignancies among gynaecological tumours, several factors. On hand, increased metabolism cancer cells can lead to ROS, on other impaired not able effectively scavenge excessive ROS. In addition, chemotherapy radiotherapy elevate cells. cause damage, promote development even result drug resistance. Therefore, studying important for prevention treatment cancer. Antioxidants, markers stress, might serve strategies preventing treating this review, we will discuss complex relationship well role therapeutic potential antioxidants thus guiding future research clinical interventions.

Language: Английский

Citations

2