Antioxidant Systems and Oxidative Stress in the Testes

Oxidative Medicine and Cellular Longevity, Journal Year: 2008, Volume and Issue: 1(1), P. 15 - 24

Published: Jan. 1, 2008

Spermatogenesis is an extremely active replicative process capable of generating approxi mately 1,000 sperm a second. The high rates cell division inherent in this imply correspondingly mitochondrial oxygen consumption by the germinal epithelium. However, poor vascularization testes means that tensions tissue are low1 and competition for vital element within intense. Since both spermatogenesis2 Leydig steroidogenesis3,4 vulnerable to oxidative stress, low tension characterizes may be important component mechanisms which protects itself from free radical-mediated damage. In addition, contain elaborate array antioxidant enzymes radical scavengers ensure twin spermatogenic steroidogenic functions organ not impacted stress. These defence systems major importance because peroxidative damage currently regarded as single most cause impaired testicular function underpinning pathological consequences wide range conditions torsion diabetes xenobiotic exposure. This chapter sets out specific nature these also reviews factors have been found impair their activity, precipitating state stress impairing latter’s ability produce viable spermatozoa initiating supporting embryonic development.

Language: Английский

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Molecular Mechanisms in Spermatogenesis

Advances in experimental medicine and biology, Journal Year: 2008, Volume and Issue: unknown

Published: Jan. 1, 2008

Language: Английский

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A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells

The Science of The Total Environment, Journal Year: 2011, Volume and Issue: 409(22), P. 4753 - 4762

Published: Aug. 18, 2011

Language: Английский

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Endocrine-disrupting chemicals and male reproductive health

Reproductive BioMedicine Online, Journal Year: 2013, Volume and Issue: 26(5), P. 440 - 448

Published: Feb. 18, 2013

Endocrine-disrupting chemicals are substances present in the environment that can interfere with normal hormonal balance and thus exert potentially adverse health effects on human organism. Male reproductive system development function may be susceptible to of such environmental toxicants. Bisphenol A, phthalates alkylphenols important components multiple products ubiquitously environment. It has been demonstrated under laboratory conditions they detrimental male system. However, exposure data scarce do not uniformly support toxicity these at concentrations. Despite substantial research efforts, final answer problem endocrine-disrupting is yet sight.

Language: Английский

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Effect of nonylphenol on male reproduction: Analysis of rat epididymal biochemical markers and antioxidant defense enzymes

Toxicology and Applied Pharmacology, Journal Year: 2012, Volume and Issue: 261(2), P. 134 - 141

Published: March 8, 2012

Language: Английский

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Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers

Biological Research, Journal Year: 2012, Volume and Issue: 45(1), P. 5 - 14

Published: Jan. 1, 2012

Bisphenol A [2,2-bis(4-hydroxyphenyl)propane] (BPA), 4-nonylphenol (NP) and di(2-ethylhexyl)phthalate (DEHP), its metabolite mono-2-ethylhexyl phthalate (MEHP) are chemicals found in plastics, which act as endocrine disruptors (EDs) animals, including human.EDs like hormones the system, disrupt physiologic function of endogenous hormones.Most people exposed to different concern has been raised about their true effect on reproductive organs.In testis, they seem preferentially attack developing testis during puberty rather than adult organs.However, lack information molecular mechanism, apparently controversial observed models hampered understanding effects mammalian spermatogenesis.In this review, we critically discuss available regarding BPA, NP DEHP/ MEHP upon spermatogenesis, a major target EDs.Germ cell sloughing, disruption blood-testis-barrier germ apoptosis most common reported literature.We propose model at level explain cellular level, mainly focused apoptosis.

Language: Английский

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Comparative toxicity, oxidative stress and endocrine disruption potential of plasticizers in JEG-3 human placental cells

Toxicology in Vitro, Journal Year: 2016, Volume and Issue: 38, P. 41 - 48

Published: Nov. 4, 2016

Language: Английский

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A Mechanism of Male Germ Cell Apoptosis Induced by Bisphenol-A and Nonylphenol Involving ADAM17 and p38 MAPK Activation

PLoS ONE, Journal Year: 2014, Volume and Issue: 9(12), P. e113793 - e113793

Published: Dec. 4, 2014

Germ cell apoptosis regulation is pivotal in order to maintain proper daily sperm production. Several reports have shown that endocrine disruptors such as Bisphenol-A (BPA) and Nonylphenol (NP) induce germ along with a decrease Given their ubiquitous distribution plastic products used by humans it important clarify mechanism of action. TACE/ADAM17 widely distributed extracellular metalloprotease participates the physiological cells during spermatogenesis. The aims this work were: 1) determine whether BPA NP ADAM17 activation; 2) study and/or ADAM10 are involved induced pubertal rat testis. A single dose or (50 mg/kg) induces 21-day-old male rats, which was prevented pharmacological inhibitor ADAM17, but not an ADAM10. In vitro, we showed NP, at similar concentrations those found human samples, shedding exogenous endogenous (TNF-α) substrates primary Sertoli cultures TM4 line. addition, inhibitors metalloproteases genetic silencing prevent vitro NP. Finally, vivo early activation (phosphorylation) p38 MAPK translocation surface. Interestingly, inhibition prevents These results show for first time xenoestrogens can suggesting they could imbalance para/juxtacrine cell-to-cell-communication apoptosis.

Language: Английский

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An updated systematic review on the possible effect of nonylphenol on male fertility

Environmental Science and Pollution Research, Journal Year: 2016, Volume and Issue: 24(4), P. 3298 - 3314

Published: Nov. 8, 2016

Language: Английский

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Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice

General and Comparative Endocrinology, Journal Year: 2015, Volume and Issue: 239, P. 50 - 61

Published: Nov. 19, 2015

Language: Английский

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