Do (xeno)estrogens pose a risk to earthworms? Soy isoflavones and estradiol impact gonad structure and induce oxidative stress in Eisenia fetida DOI Creative Commons
Tiago Azevedo, Rita Silva‐Reis, Beatriz Medeiros‐Fonseca

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 377, P. 144315 - 144315

Published: March 28, 2025

Understanding the impact of endocrine disruptor compounds (EDCs) across a wide range species is crucial, given their ubiquitous presence. Although invertebrate lack sex steroid hormone pathways, they exhibit sensitivity to EDCs, which could affect population dynamics. This study assessed reproductive endpoints and oxidative stress parameters in Eisenia fetida following exposure estradiol soy isoflavones, resembling concentrations found livestock manure. The experiment used artificial soil, as recommended by OECD guidelines (7:2:1 sand, kaolin peat). Adult specimens were randomly divided into seven groups (n = 11/replicate): one control, three (156.1, 283.4 633.8 μg/kg dry soil) isoflavones (113.0, 215.3 405.0 mg/kg concentrations. After eight weeks, samples collected for cytological, histological biochemical analysis. Offspring development was after 12 additional weeks. Higher isoflavone led lower germ cell number increased abnormalities, especially seminal vesicles ovaries. Catalase peroxidase activities significantly all treated groups. did not E. offspring. These findings highlight fetida's EDCs at tissue level, suggesting its use bioindicator assessing EDC contamination soils.

Language: Английский

Worldwide risk assessment of phthalates and bisphenol A in humans: The need for updating guidelines DOI Creative Commons
Jaime Dueñas-Moreno, Abrahan Mora, Manish Kumar

et al.

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108294 - 108294

Published: Oct. 28, 2023

Phthalates and bisphenol A (BPA) are compounds widely used as raw materials in the production of plastics, making them ubiquitous our daily lives. This results widespread human exposure health hazards. Although efforts have been conducted to evaluate risk these diverse regions around world, data scattering may mask important trends that could be useful for updating current guidelines regulations. study offers a comprehensive global assessment levels chemicals, considering dietary nondietary ingestion, evaluates associated risk. Overall, intake (EDI) values phthalates BPA reported worldwide ranged from 1.11 × 10−7 3 700 µg kg bw−1 d−1 3.00 10−5 6.56 d−1, respectively. Nevertheless, dose-additive effect has shown increase EDI up 5 100 representing high terms noncarcinogenic (HQ) carcinogenic (CR) effects. The HQ 2.25 3.66 2.74 9.72 10−2, Meanwhile, significant number studies exhibit CR benzyl butyl phthalate (BBP) di(2-ethylhexyl) (DEHP). Moreover, DEHP highest maximum mean humans numerous studies, 179-fold higher than BBP. Despite mounting evidence harmful effects chemicals at low-dose on animals humans, most regulations not updated. Thus, this article emphasizes need public policies compelling adverse exposure, it cautions against use alternative plasticizers substitutes because gaps their safety.

Language: Английский

Citations

43
The adverse role of endocrine disrupting chemicals in the reproductive system DOI Creative Commons

Jing Pan,

Pengfei Liu,

Xiao Yu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 17, 2024

Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.

Language: Английский

Citations

42
Comparison of phthalate esters (PAEs) in freshwater and marine food webs: Occurrence, bioaccumulation, and trophodynamics DOI
Baolin Liu,

Linyang Lv,

Lingjie Ding

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133534 - 133534

Published: Jan. 18, 2024

Language: Английский

Citations

36
A systematic review of global distribution, sources and exposure risk of phthalate esters (PAEs) in indoor dust DOI
Junjie Li, Baolin Liu,

Yong Yu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134423 - 134423

Published: April 25, 2024

Language: Английский

Citations

24
From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality DOI Creative Commons
Irma Virant‐Klun,

Senka Imamovic-Kumalic,

Bojana Pinter

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1617 - 1617

Published: Aug. 20, 2022

Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction development. In male reproductive health, EDCs been related impaired function infertility, altered fetal development, testicular germ-cell, prostate, breast cancers. We conducted electronic search using PubMed disruptors evaluated their association with (bisphenols, phthalates, parabens) 25 articles. Higher levels of urinary bisphenols showed correlation semen quality increased DNA damage. Considering phthalates metabolites, all studies found a positive between at least one parameter indicative low quality; some also revealed sperm The parabens less often concentrations decrease count, as well motility Moreover, elevate ROS production lipid peroxidation, increase apoptosis, induce epigenetic modifications, change the Y:X chromosome ratio protein composition. Our review detrimental effects integrity—especially BPA but parabens.

Language: Английский

Citations

54
Cumulative Exposure to Phthalates and Their Alternatives and Associated Female Reproductive Health: Body Burdens, Adverse Outcomes, and Underlying Mechanisms DOI

Xueyu Weng,

Qingqing Zhu, Chunyang Liao

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(22), P. 8189 - 8212

Published: May 17, 2023

The global birth rate has recently shown a decreasing trend, and exposure to environmental pollutants been identified as potential factor affecting female reproductive health. Phthalates have widely used plasticizers in plastic containers, children's toys, medical devices, their ubiquitous presence endocrine-disrupting already raised particular concerns. Phthalate linked various adverse health outcomes, including diseases. Given that many phthalates are gradually being banned, growing number of phthalate alternatives becoming popular, such di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH), di(2-ethylhexyl) adipate (DEHA), terephthalate (DEHTP), they beginning wide range effects. Studies may disrupt function by altering the estrous cycle, causing ovarian follicular atresia, prolonging gestational which raises concerns about risks. Herein, we summarize effects common different models, levels influence system, on impairment, pregnancy offspring development. Additionally, scrutinize hormone signaling, oxidative stress, intracellular signaling explore underlying mechanisms action health, because these chemicals affect tissues directly or indirectly through endocrine disruption. declining trends capacity ability negatively impact more comprehensive study is needed understand human body mechanisms. These findings an important role improving turn complications during pregnancy.

Language: Английский

Citations

32
Impact of DEHP exposure on female reproductive health: Insights into uterine effects DOI
Alejandra Martínez-Ibarra, Marco Cerbón, Luis Daniel Martínez-Razo

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 107, P. 104391 - 104391

Published: Feb. 16, 2024

Language: Английский

Citations

9
Associations of phthalate and phthalate alternative metabolites in urine with the risk of gallstones in adults: a cross-sectional analysis DOI
Tianshan Shi, Di Li, Donghua Li

et al.

Environmental Geochemistry and Health, Journal Year: 2025, Volume and Issue: 47(2)

Published: Jan. 6, 2025

Language: Английский

Citations

1
Uptake, translocation, and biotransformation of phthalate acid esters in crop plants: A comprehensive review DOI
Nai-Xian Feng, Bogui Pan,

Hong-Jia Huang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137580 - 137580

Published: Feb. 11, 2025

Language: Английский

Citations

1
Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro DOI Creative Commons
Eleftheria Maria Panagiotou, Anastasios Damdimopoulos, Tianyi Li

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 505, P. 153815 - 153815

Published: April 27, 2024

Phthalates are found in everyday items like plastics and personal care products. There is an increasing concern that continuous exposure can adversely affect female fertility. However, experimental data lacking to establish causal links between disease humans. To address this gap, we tested the effects of a common phthalate metabolite, mono-(2-ethylhexyl) (MEHP), on adult human ovaries vitro using epidemiologically determined human-relevant concentration range (2.05 nM – 20.51 mM). Histomorphological assessments, steroid cytokine measurements were performed ovarian tissue exposed MEHP for 7 days vitro. Cell viability gene expression profile investigated following granulosa cancer cell lines (KGN, COV434), germline tumor line (PA-1), primary cells. Selected differentially expressed genes (DEGs) validated by RT-qPCR immunofluorescence tissue. reduced follicular growth (20.51 nM) increased degeneration mM) tissue, while not affecting production. Out 691 unique DEGs identified across all types concentrations, CSRP2 involved cytoskeleton organization YWHAE as well CTNNB1 Hippo pathway, chosen further validation. was upregulated downregulated both cells, whereas cells only. In summary, one-week perturb development survival follicles through mechanisms likely involving dysregulation pathway.

Language: Английский

Citations

5