BACKGROUND
The
relationship
between
24-hour
rest-activity
rhythms
(RARs)
and
risk
for
dementia
or
mild
cognitive
impairment
(MCI)
remains
an
area
of
growing
interest.
Previous
studies
were
often
limited
by
small
sample
sizes,
short
follow-ups,
older
participants.
More
are
required
to
fully
explore
the
link
disrupted
RARs
MCI
in
middle-aged
adults.
OBJECTIVE
We
leveraged
UK
Biobank
data
examine
how
RAR
disturbances
correlate
with
developing
METHODS
analyzed
91,517
participants
aged
43
79
years.
Wrist
actigraphy
recordings
used
derive
nonparametric
metrics,
including
activity
level
most
active
10-hour
period
(M10)
its
midpoint,
least
5-hour
(L5)
relative
amplitude
(RA)
cycle
[RA=(M10-L5)/(M10+L5)],
interdaily
stability,
intradaily
variability,
as
well
acrophase
(cosinor
analysis).
Cox
proportional
hazards
models
associations
baseline
subsequent
incidence
MCI,
adjusting
demographic
characteristics,
comorbidities,
lifestyle
factors,
shiftwork
status,
genetic
Alzheimer's
disease.
RESULTS
During
follow-up
up
7.5
years,
555
developed
dementia.
increased
those
lower
M10
(hazard
ratio
[HR]
1.28,
95%
CI
1.14-1.44,
per
1-SD
decrease),
higher
L5
(HR
1.15,
1.10-1.21,
increase),
RA
1.23,
1.16-1.29,
1.32,
1.17-1.49,
variability
1.14,
1.05-1.24,
increase)
advanced
midpoint
0.92,
0.85-0.99,
advance).
These
similar
people
<70
>70
non–shift
workers,
they
independent
cardiovascular
factors.
No
significant
observed
acrophase.
CONCLUSIONS
Based
on
findings
from
a
large
middle-to-older
adults
objective
assessment
almost
8-years
follow-up,
we
suggest
that
suppressed
fragmented
daily
precede
onset
may
serve
biomarkers
preclinical
World Allergy Organization Journal,
Journal Year:
2024,
Volume and Issue:
17(1), P. 100851 - 100851
Published: Jan. 1, 2024
BackgroundChronic
respiratory
diseases
(CRDs)
pose
a
significant
global
health
burden.
Antioxidant-rich
diets
have
been
associated
with
improved
lung
health,
but
the
specific
relationship
CRDs
remains
unclear.MethodsThis
study
examined
between
dietary
antioxidant
intakes
and
using
data
from
2001–2018
National
Health
Nutrition
Examination
Survey
(NHANES).
Information
on
intakes,
including
vitamins
A,
C,
E,
zinc,
selenium,
carotenoid,
were
collected
2
24-h
recall
interviews
to
calculate
composite
index
(CDAI).
determined
based
self-reported
physician
diagnoses.
To
examine
CDAI
CRDs,
multivariate
logistic
regression
was
used.
potential
non-linear
correlations
within
these
associations,
restricted
cubic
spline
(RCS)
performed.ResultsThe
involved
40
557
individuals.
The
median
−0.09
(−2.05,
2.25).
We
discovered
those
who
in
fourth
quartile
of
scores
had
19%
lower
prevalence
than
first
(OR
=
0.81
[0.72–0.91],
Ptrend
<
0.01)
after
adjusting
for
all
relevant
covariates.
linked
emphysema
0.57
[0.40–0.81],
chronic
bronchitis
0.74
[0.62–0.88],
0.01).
RCS
showed
that
non-linearly
related
inflection
points
3.20
(P
non-linearity
<0.01).
stratified
analysis
did
not
identify
variables
significantly
affected
results.ConclusionHigher
(particularly
bronchitis)
general
adults.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 26, 2024
Flavonoids
are
a
class
of
secondary
plant
metabolites
that
have
been
shown
to
multiple
health
benefits,
including
antioxidant
and
anti-inflammatory.
This
study
was
explore
the
association
between
dietary
flavonoid
consumption
prevalence
chronic
respiratory
diseases
(CRDs)
in
adults.
The
six
main
types
flavonoids,
isoflavones,
anthocyanidins,
flavan-3-ols,
flavanones,
flavones,
flavonols,
were
obtained
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007-2010
2017-2018
by
two
24-h
recall
interviews.
CRDs,
asthma,
emphysema,
bronchitis,
determined
through
self-administered
questionnaire.
analysis
included
15,753
participants
aged
18
years
or
older
who
had
completed
diet
history
interview.
After
adjustment
for
potential
confounders,
inverse
link
found
with
total
an
OR
(95%CI)
0.86
(0.75-0.98),
0.84
(0.72-0.97),
0.80(0.69-0.92),
0.85(0.73-0.98)
highest
group
compared
lowest
group.
WQS
regression
revealed
mixture
flavonoids
negatively
linked
CRDs
(OR
=
0.88
[0.82-0.95],
P
<
0.01),
largest
effect
mainly
flavanones
(weight
0.41).
In
addition,
we
intake
inflammatory
markers,
systemic
inflammation
significantly
mediated
associations
mediation
rate
12.64%
CRP
(P
0.01).
Higher
related
lower
adults,
this
relationship
may
be
inflammation.
Critical Care Medicine,
Journal Year:
2024,
Volume and Issue:
52(8), P. 1206 - 1217
Published: April 10, 2024
OBJECTIVES:
To
investigate
the
sleep
and
circadian
health
of
critical
survivors
12
months
after
hospital
discharge
to
evaluate
a
possible
effect
severity
disease
within
this
context.
DESIGN:
Observational,
prospective
study.
SETTING:
Single-center
PATIENTS:
Two
hundred
sixty
patients
admitted
ICU
due
severe
acute
respiratory
syndrome
coronavirus
2
infection.
INTERVENTIONS:
None.
MEASUREMENTS
AND
MAIN
RESULTS:
The
cohort
was
composed
260
(69.2%
males),
with
median
(quartile
1–quartile
3)
age
61.5
years
(52.0–67.0
yr).
length
stay
11.0
days
(6.00–21.8
d),
where
56.2%
required
invasive
mechanical
ventilation
(IMV).
Pittsburgh
Sleep
Quality
Index
(PSQI)
revealed
that
43.1%
presented
poor
quality
discharge.
Actigraphy
data
indicated
an
influence
on
fragmentation
rest-activity
rhythm
at
3-
6-month
follow-ups,
which
no
longer
significant
in
long
term.
Still,
duration
IMV
predicted
higher
12-month
follow-up
sizes
(95%
CI)
0.248
(0.078–0.418)
0.182
(0.005–0.359),
respectively.
Relevant
associations
between
PSQI
Hospital
Anxiety
Depression
Scale
(rho
=
0.55,
anxiety;
rho
0.5,
depression)
as
well
diffusing
lung
capacity
for
carbon
monoxide
–0.35)
were
observed
time
point.
CONCLUSIONS:
Our
findings
reveal
great
prevalence
presenting
persistence
alterations
impact
rhythm,
attenuated
follow-up.
This
altogether
highlights
relevance
considering
JMIR Public Health and Surveillance,
Journal Year:
2024,
Volume and Issue:
10, P. e55211 - e55211
Published: March 16, 2024
Background
The
relationship
between
24-hour
rest-activity
rhythms
(RARs)
and
risk
for
dementia
or
mild
cognitive
impairment
(MCI)
remains
an
area
of
growing
interest.
Previous
studies
were
often
limited
by
small
sample
sizes,
short
follow-ups,
older
participants.
More
are
required
to
fully
explore
the
link
disrupted
RARs
MCI
in
middle-aged
adults.
Objective
We
leveraged
UK
Biobank
data
examine
how
RAR
disturbances
correlate
with
developing
Methods
analyzed
91,517
participants
aged
43
79
years.
Wrist
actigraphy
recordings
used
derive
nonparametric
metrics,
including
activity
level
most
active
10-hour
period
(M10)
its
midpoint,
least
5-hour
(L5)
relative
amplitude
(RA)
cycle
[RA=(M10-L5)/(M10+L5)],
interdaily
stability,
intradaily
variability,
as
well
acrophase
(cosinor
analysis).
Cox
proportional
hazards
models
associations
baseline
subsequent
incidence
MCI,
adjusting
demographic
characteristics,
comorbidities,
lifestyle
factors,
shiftwork
status,
genetic
Alzheimer's
disease.
Results
During
follow-up
up
7.5
years,
555
developed
dementia.
increased
those
lower
M10
(hazard
ratio
[HR]
1.28,
95%
CI
1.14-1.44,
per
1-SD
decrease),
higher
L5
(HR
1.15,
1.10-1.21,
increase),
RA
1.23,
1.16-1.29,
1.32,
1.17-1.49,
variability
1.14,
1.05-1.24,
increase)
advanced
midpoint
0.92,
0.85-0.99,
advance).
These
similar
people
<70
>70
non–shift
workers,
they
independent
cardiovascular
factors.
No
significant
observed
acrophase.
Conclusions
Based
on
findings
from
a
large
middle-to-older
adults
objective
assessment
almost
8-years
follow-up,
we
suggest
that
suppressed
fragmented
daily
precede
onset
may
serve
biomarkers
preclinical
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(10), P. e31524 - e31524
Published: May 1, 2024
ObjectiveTo
investigate
whether
inflammatory
indices,
including
the
systemic
immune-inflammation
index
(SII),
neutrophil-to-lymphocyte
ratio
(NLR),
platelet-to-lymphocyte
(PLR),
product
of
platelet
and
neutrophil
count
(PPN),
lymphocyte-to-monocyte
(LMR),
correlate
with
chronic
obstructive
pulmonary
disease
(COPD).MethodsThis
was
a
cross-sectional
study
from
National
Health
Nutrition
Examination
Survey
(NHANES)
database
2007-2018.
The
SII,
NLR,
PLR,
PPN
LMR
were
calculated
based
on
blood
cell
counts
log2-transformed.
COPD
diagnosed
via
questionnaire
or
spirometry
examination.
Multivariate
logistic
regression,
sensitivity
analysis,
subgroup
interaction
tests
performed
to
evaluate
relationships.Results23,875
participants,
1,000
patients
(453
examination,
547
questionnaire),
enrolled
in
this
study.
Positive
associations
observed
between
SII
(OR
1.231,
95%
CI
1.081,1.401),
NLR
1.223,
1.064,1.405),
PLR
1.325
1.086,1.617),
1.157
1.031,1.298)
COPD,
while
negative
association
obtained
0.794,
0.666,0.948)
after
covariate
adjustments.
When
divided
into
spirometry-based
questionnaire-based,
only
1.310,
95%CI
1.122,1.529),
1.669,95%CI
1.272,2.191)
1.218,
1.050,1.412)
significantly
correlated
1.303,
1.055,1.609)
0.524,95%CI
0.406,0.677)
questionnaire-based
adjustments.ConclusionSignificant
are
different
inflammation
indices
COPD.
Heterogeneity
exists
patients.
Future
studies
needed
verify
results.
BMC Geriatrics,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 11, 2025
Diet
plays
a
crucial
part
in
maintaining
healthy
body,
and
microbes,
as
an
essential
dietary
component,
have
attracted
more
attention
recent
years.
In
this
study,
we
will
explore
the
link
between
intake
of
live
microbes
frailty
elderly.
Older
participants
from
1999–2018
National
Health
Nutrition
Examination
Survey
(NHANES)
who
were
not
less
than
60
years
age
enrolled
research.
Participants'
microbe
was
assessed
by
self-report
questionnaire.
Participants
stratified
into
low,
medium,
high
groups
according
to
their
consumption
foods
with
varying
microbial
content.
The
index
49
indicators.
Frailty
defined
>
0.21.
Logistic
regression
used
analyze
older
adults.
A
total
15,179
adults'
basic
information
collected
for
study.
higher
0.21
32.8%
participants.
adults
accounted
33.5%,
47.0%,
19.5%,
respectively.
models
adjusted
confounders,
prevalence
lower
medium
(OR
=
0.825,
95%CI:
0.749–0.908)
0.779,
0.679–0.894)
groups,
compared
lowest
group.
RCS
analysis
revealed
significant
non-linear
association
prevalence,
strongest
reduction
observed
below
inflection
point
161.82
(P
non-linearity
<
0.05).
addition,
analyses
did
reveal
interactions
study
variables.
This
demonstrates
negative
These
findings
provide
evidence
potential
frailty,
warranting
further
longitudinal
interventional
studies
relationship
its
implications
aging.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 17, 2024
Objective
The
study
explores
the
association
between
inflammation/nutrition-based
indicators,
Parkinson’s
disease
(PD),
and
all-cause
mortality
among
adult
participants.
Methods
analysis
included
38,091
participants
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999–2018.
Inflammation/nutrition-based
indicators
were
derived
a
comprehensive
set
of
parameters,
including
neutrophil-albumin
ratio
(NAR),
prognostic
nutritional
index
(PNI),
monocyte-albumin
(MAR),
red
cell
distribution
width-albumin
(RAR),
hemoglobin,
albumin,
lymphocyte,
platelet
(HALP)
score,
advanced
lung
cancer
inflammation
(ALI),
geriatric
nutrition
risk
(GNRI),
controlling
status
(CONUT)
score.
PD
was
determined
based
on
self-reported
anti-parkinsonian
medication
use.
Mortality
data
obtained
Death
Index,
linked
up
to
December
30,
2019.
Results
After
multivariate
adjustment,
all
showed
significant
associations
with
random
survival
forest
emphasized
importance
their
components
in
predicting
mortality,
PNI
RAR
being
most
important
for
mortality.
Individuals
have
significantly
higher
compared
those
without
(HR
=
1.747
[1.363–2.238],
P
<
0.001)
adults.
Additionally,
elevated
levels
are
associated
individuals
PD.
This
suggested
synergistic
effect
inflammatory/nutritional
risk.
Specifically,
NAR
2.066
[1.398–3.052],
0.001),
MAR
2.249
[1.612–3.138],
1.617
[1.179–2.218],
0.003),
ALI
1.763
[1.225–2.537],
0.002)
CONUT
2.221
[1.434–3.440],
not
1.771
[1.295–2.423],
HALP
1.738
[1.242–2.432],
GNRI
2.689
[1.898–3.811],
substantially
Conclusion
Inflammation
play
crucial
roles
adults,
particularly
context
underscores
considering
both
factors
assessment
provides
valuable
insights
future
research
clinical
practice.
