Association of Rest Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population (Preprint) DOI
Shahab Haghayegh, Chenlu Gao, Elizabeth Sugg

et al.

Published: Dec. 11, 2023

BACKGROUND The relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, older participants. More are required to fully explore the link disrupted RARs MCI in middle-aged adults. OBJECTIVE We leveraged UK Biobank data examine how RAR disturbances correlate with developing METHODS analyzed 91,517 participants aged 43 79 years. Wrist actigraphy recordings used derive nonparametric metrics, including activity level most active 10-hour period (M10) its midpoint, least 5-hour (L5) relative amplitude (RA) cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, intradaily variability, as well acrophase (cosinor analysis). Cox proportional hazards models associations baseline subsequent incidence MCI, adjusting demographic characteristics, comorbidities, lifestyle factors, shiftwork status, genetic Alzheimer's disease. RESULTS During follow-up up 7.5 years, 555 developed dementia. increased those lower M10 (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 (HR 1.15, 1.10-1.21, increase), RA 1.23, 1.16-1.29, 1.32, 1.17-1.49, variability 1.14, 1.05-1.24, increase) advanced midpoint 0.92, 0.85-0.99, advance). These similar people <70 >70 non–shift workers, they independent cardiovascular factors. No significant observed acrophase. CONCLUSIONS Based on findings from a large middle-to-older adults objective assessment almost 8-years follow-up, we suggest that suppressed fragmented daily precede onset may serve biomarkers preclinical

Language: Английский

Evaluating the Incremental Value of an Expanded Cardiovascular Health Score for the Prevalence of Abdominal Aortic Calcification Among Middle-aged and Elderly Individuals DOI Creative Commons
Qidi Ying,

Zaoping Chen,

Xue Xiaobo

et al.

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: unknown, P. 200389 - 200389

Published: March 1, 2025

Language: Английский

Citations

0
The Critical Role of Sleep in Enhancing Pulmonary Rehabilitation Outcomes DOI
Mario Henríquez‐Beltrán, Jessica M Gonzalez, Gonzalo Labarca

et al.

Seminars in Respiratory and Critical Care Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Pulmonary rehabilitation is a comprehensive, interdisciplinary intervention that aims to enhance the physical and psychological well-being of individuals with chronic respiratory diseases. This approach entails implementation tailored therapies, including exercise training, education, behavioral modification. Sleep plays crucial role in numerous physiological processes, regulation inflammation tissue repair, both which are fundamental efficacy rehabilitation. A paucity optimal sleep health has been associated deleterious effects on pivotal factors indispensable for favorable outcomes pulmonary rehabilitation, mental immune function. This, turn, may increase susceptibility impaired The integration protocols healthy practices expected yield significant improvements lung function overall health, will, promote long-term adherence rehabilitative behaviors. study examine relationship between outcomes.

Language: Английский

Citations

0
Comparative Discrimination of Life’s Simple 7, Life’s Essential 8, and Life’s Crucial 9: Evaluating the impact of added complexity on mortality prediction DOI Creative Commons
Xu Zhu, Iokfai Cheang, Yuan Fu

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 6, 2025

Language: Английский

Citations

0
Association of Life's Essential 8 with abdominal aortic calcification and mortality among middle‐aged and older individuals DOI

Gehui Ni,

Qinfeng Jia,

Ying Li

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(11), P. 5126 - 5137

Published: Aug. 20, 2024

To assess the association of Life's Essential 8 (LE8) and presence abdominal aortic calcification (AAC) with mortality among middle-aged older individuals.

Language: Английский

Citations

3
Association of 24 h Behavior Rhythm with Non-Alcoholic Fatty Liver Disease among American Adults with Overweight/Obesity DOI Open Access

Wenbo Gu,

Tianshu Han,

Changhao Sun

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2101 - 2101

Published: April 27, 2023

Emerging evidence suggests that in addition to metabolic, genetic and environmental factors, circadian rhythm also plays a role non-alcoholic fatty liver disease (NAFLD). This study aimed explore the association of 24 h behavior (activity-rest feeding-fasting rhythm) with NAFLD. A total 4502 adult participants overweight/obesity from National Health Nutrition Examination Survey (NHANES) 2011-2014 were included current study. The indices calculated divided into quintiles for logistic regression models. Compared those lowest quintile, highest quintile relative amplitude (RA) had lower risk NAFLD (OR = 0.71, 95% CI, 0.55-0.91); average activity least active continuous 5 period (L5) associated higher 1.35, 1.07-1.71). Additionally, fasting duration feeding score 0.76, 0.59-0.98 duration, OR 0.74, 0.58-0.95 score). associations stronger among obesity. No significant found relationship other indicated American adults overweight/obesity.

Language: Английский

Citations

4
Exploring the relationship between live microbe intake and obesity prevalence in adults DOI Creative Commons

Yuting Chen,

Haixiang Ni,

Hong Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 17, 2024

Obesity has become a global health problem. In recent years, the influence of dietary microbes in obese population attracted attention scholars. Our study aimed to investigate link between live microbe intake and obesity adults. Participants (aged over 20 years) for this were from 1999-2018 National Health Nutrition Examination Survey (NHANES). categorised into low, medium high groups. Linear regression was used analyse body mass index (BMI) waist circumference (WC). Logistic abdominal prevalence. Restricted cubic spline curves (RCS) check whether there non-linear relationship obesity. A total 42,749 participants included number reached 15,463. We found that negatively linked BMI WC. models adjusted all confounders, group had lower (OR = 0.812, 95%CI: 0.754-0.873) prevalence 0.851, 0.785-0.923) than lowest group. Upon further quantification intake, we similar results. RCS analyses showed nonlinearly correlated with BMI, WC, obesity, (P non-linearity < 0.05). This preliminarily reveals negative

Language: Английский

Citations

1
Associations between inflammatory burden index, prostate cancer, and mortality among middle-aged and elderly individuals DOI
Junpeng Deng,

Jingqi Hua,

Tengyue Zeng

et al.

World Journal of Urology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Sept. 26, 2024

Language: Английский

Citations

1
A network of pro-inflammatory genes repressed by clock signaling in bronchial epithelium DOI Creative Commons
Xiaopeng Li, Karthi Srikanthan, Siti Farah Rahmawati

et al.

ERJ Open Research, Journal Year: 2024, Volume and Issue: 11(3), P. 00605 - 2024

Published: Nov. 7, 2024

Background Circadian rhythms are biological cycles that regulate various physiological processes, including immune responses, tissue repair and oxidative stress. Previous studies indicated a role for distorted circadian signalling in COPD. Methods In this study, we performed an unbiased analysis of the gene network coexpressed with clock COPD using weighted coexpression on RNA sequencing data from bronchial brushes patients. Results We found large pro-inflammatory genes, CXCL8 , IL1B IL1A CSF1 TGFB1 was inversely correlated expression core genes contrast, positively associated ciliated cell differentiation. Furthermore, both their were differentially expressed lung tissues patients compared healthy smokers. Conclusions Our results provide comprehensive epithelium. findings suggest association between enhanced inflammatory

Language: Английский

Citations

0
The association of 24-hour behavior rhythms with stroke among American adults with prediabetes/diabetes: evidence from NHANES 2011–2014 DOI Creative Commons

Wenbo Gu,

Zhen Tian, Wanying Hou

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 25, 2024

Emerging evidence suggests that circadian rhythms play a role in the regulation of cardiovascular diseases (CVDs). We aim to examine relationship between 24-hour behavior (activity-rest and feeding-fasting rhythms) stroke. The study included 3201 adult participants with prediabetes/diabetes from National Health Nutrition Examination Survey (NHANES) 2011-2014. rhythm indices were calculated using data accelerometer wearable device dietary recall for two nonconsecutive days. Six including interdaily stability (IS), intradaily variability (IV), relative amplitude (RA), average activity during least active continuous 5-hour period (L5), Average most 10-hour (M10) which reflects activity-rest rhythm, feeding score rhythm. These variables divided into quintiles logistic regression models. Comparing quintile 1, those 5 IS RA exhibited lower odds Conversely, IV, L5, L5 start time demonstrated higher Furthermore, had significantly associations IV stroke more pronounced diabetes compared prediabetes/diabetes. No significant observed other Overall, this highlights association American adults

Language: Английский

Citations

0
Association of Rest Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population (Preprint) DOI
Shahab Haghayegh, Chenlu Gao, Elizabeth Sugg

et al.

Published: Dec. 11, 2023

BACKGROUND The relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, older participants. More are required to fully explore the link disrupted RARs MCI in middle-aged adults. OBJECTIVE We leveraged UK Biobank data examine how RAR disturbances correlate with developing METHODS analyzed 91,517 participants aged 43 79 years. Wrist actigraphy recordings used derive nonparametric metrics, including activity level most active 10-hour period (M10) its midpoint, least 5-hour (L5) relative amplitude (RA) cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, intradaily variability, as well acrophase (cosinor analysis). Cox proportional hazards models associations baseline subsequent incidence MCI, adjusting demographic characteristics, comorbidities, lifestyle factors, shiftwork status, genetic Alzheimer's disease. RESULTS During follow-up up 7.5 years, 555 developed dementia. increased those lower M10 (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 (HR 1.15, 1.10-1.21, increase), RA 1.23, 1.16-1.29, 1.32, 1.17-1.49, variability 1.14, 1.05-1.24, increase) advanced midpoint 0.92, 0.85-0.99, advance). These similar people &lt;70 &gt;70 non–shift workers, they independent cardiovascular factors. No significant observed acrophase. CONCLUSIONS Based on findings from a large middle-to-older adults objective assessment almost 8-years follow-up, we suggest that suppressed fragmented daily precede onset may serve biomarkers preclinical

Language: Английский

Citations

0