Research Note: Reduction of Salmonella load in Brazilian commercial chicken farms using INSPEKTOR®: a bacteriophage-based product DOI Creative Commons
Michael Pino, Karen Mujica,

Paola Mora-Uribe

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104544 - 104544

Published: Nov. 16, 2024

Salmonella is a zoonotic pathogen transmitted through food and one of the four leading global causes diarrheal disease in humans. Brazil world's largest exporter poultry meat, as such, Brazilian farms routinely detect prevent Salmonella. The last official monitoring control slaughter establishments 2023 detected spp. 14.80 % samples from chickens, those Salmonella-positive were classified serovar Minnesota 65.76 samples, Heidelberg 16.10 another 26 or more serovars non-typeable represented total 18.13 samples. However, despite these measures, several diseases outbreaks have been reported recent decades, requiring permanent control. Bacteriophages, which act specific parasites bacterial cells, can contribute to safety. This study evaluated effectiveness INSPEKTOR® phage cocktail for controlling on 17 commercial broiler 4 experimental groups (1 cycle 3 consecutive treatment cycles) using doses each cycle. load was quantified (DNA copies/mL) by real-time PCR invA marker spp., together with Heidelberg, are relevant industry Brazil. Our results showed that reduced 0.5 up 6 logs cycles compared cycle, all cycles. it involves applying capable reducing real production systems over million chickens.

Language: Английский

Bacteriophage Therapy in Companion and Farm Animals DOI Creative Commons
Laura Bianchessi,

Giulia De Bernardi,

Martina Vigorelli

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(4), P. 294 - 294

Published: March 23, 2024

Bacteriophages, which are viruses with restricted tropism for bacteria, have been employed over a century as antimicrobial agents; they largely abandoned in Western countries but constantly used Eastern European the advent of antibiotics. In recent decades, growing spread multidrug-resistant pose serious threat to worldwide public health, imposed an urgent demand alternative therapeutic approaches antibiotics animal and human fields. Based on this requirement, numerous studies published developing testing bacteriophage-based therapy. Overall, literature supports potential perspective also highlights need additional research current standards inadequate receive approval from regulatory authorities. This review aims update critically revise knowledge application bacteriophages treat bacterial-derived infectious diseases animals order provide topical perspectives innovative advances.

Language: Английский

Citations

4
Effectiveness of a single-dose phage cocktail on the reduction of multidrug-resistant Escherichia coli in suckling piglets DOI

Viphavanh Chanthavong,

Nattha Vigad,

Wattana Pelyuntha

et al.

Veterinary Microbiology, Journal Year: 2025, Volume and Issue: 302, P. 110395 - 110395

Published: Jan. 13, 2025

Language: Английский

Citations

0
Efficiency, cytotoxicity, and survivability evaluation of Salmonella phage cocktail against Salmonella derived from broiler sources DOI Creative Commons
Wattana Pelyuntha,

Thamonwan Narkpao,

David Yembilla Yamik

et al.

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 475 - 483

Published: Feb. 1, 2025

Background and Aim: Salmonella is a leading cause of foodborne illnesses worldwide, often linked to poultry products. Antibiotic resistance among strains has increased the need for alternative decontamination strategies, such as bacteriophage (phage) therapy. This study evaluates lytic efficiency, cytotoxicity, survivability phage cocktail derived from wastewater sources. Materials Methods: A total 251 enterica isolates broiler production chains were tested against two selected phages (WP109 WP128). The characterized ability, cytotoxicity on Caco-2 cells, under simulated gastrointestinal harsh environmental conditions. was further efficiency at different multiplicities infection (MOIs) representative strains. Results: Phage WP109 lysed 91.2% isolates, while WP128 78.2%. exhibited significant reduction counts MOI 104, achieving up 4.4 log CFU/mL in vitro. maintained 99.9% gastric conditions displayed no cytotoxic effects cells. Moreover, it resistant various ionic sanitizers pH levels ranging 2 11. Conclusion: developed demonstrated high efficacy, stability, safety conditions, highlighting its potential biocontrol agent chain. These findings support application reducing contamination addressing challenges posed by antibiotic resistance. Keywords: resistance, therapy, food safety, cocktail, production, Salmonella.

Language: Английский

Citations

0
Impact of VAM-S Bacteriophage Solution on the Environmental Microbiome in Poultry Litter Systems from Commercial Operations DOI Creative Commons

Irma Janania Gamez,

Mindy M. Brashears, Kendra K. Nightingale

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105117 - 105117

Published: April 1, 2025

Language: Английский

Citations

0
Reviving hope: Phage therapy application for antimicrobial resistance in farm animal production over the past decade DOI Creative Commons
Mebratu Melaku, Junhong Wang, Yining Xie

et al.

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116333 - 116333

Published: April 1, 2025

Language: Английский

Citations

0
Wild-type lytic bacteriophages against Salmonella Heidelberg: Further characterization and effect of prophylactic therapy in broiler chickens DOI
C. S. L. Vaz, Francisco Noé da Fonseca, Daiane Voss-Rech

et al.

Research in Veterinary Science, Journal Year: 2024, Volume and Issue: 171, P. 105247 - 105247

Published: March 26, 2024

Language: Английский

Citations

2
Salmonella: Infection mechanism and control strategies DOI

Juane Lu,

Hao Wu, Shengbo Wu

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 292, P. 128013 - 128013

Published: Dec. 12, 2024

Language: Английский

Citations

1
Biological and genomic characterization of a polyvalent phage PSH-1 against multidrug-resistant Salmonella Enteritidis DOI Creative Commons

Shuai-hua Li,

Rui-Yun Wang,

Junkai Zhang

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 16, 2024

Bacteriophage has been renewed attention as a new antibacterial agent due to the limitations of antibiotic treatment. Bacteriophages are generally thought be highly host specific and even strain specific, but small number polyvalent bacteriophages have found infect bacteria different genera.

Language: Английский

Citations

0
Research Note: Reduction of Salmonella load in Brazilian commercial chicken farms using INSPEKTOR®: a bacteriophage-based product DOI Creative Commons
Michael Pino, Karen Mujica,

Paola Mora-Uribe

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104544 - 104544

Published: Nov. 16, 2024

Salmonella is a zoonotic pathogen transmitted through food and one of the four leading global causes diarrheal disease in humans. Brazil world's largest exporter poultry meat, as such, Brazilian farms routinely detect prevent Salmonella. The last official monitoring control slaughter establishments 2023 detected spp. 14.80 % samples from chickens, those Salmonella-positive were classified serovar Minnesota 65.76 samples, Heidelberg 16.10 another 26 or more serovars non-typeable represented total 18.13 samples. However, despite these measures, several diseases outbreaks have been reported recent decades, requiring permanent control. Bacteriophages, which act specific parasites bacterial cells, can contribute to safety. This study evaluated effectiveness INSPEKTOR® phage cocktail for controlling on 17 commercial broiler 4 experimental groups (1 cycle 3 consecutive treatment cycles) using doses each cycle. load was quantified (DNA copies/mL) by real-time PCR invA marker spp., together with Heidelberg, are relevant industry Brazil. Our results showed that reduced 0.5 up 6 logs cycles compared cycle, all cycles. it involves applying capable reducing real production systems over million chickens.

Language: Английский

Citations

0