Investigation of choroid plexus variability in schizophrenia-spectrum disorders – insights from a multimodal study DOI Creative Commons
Vladislav Yakimov, Joanna Moussiopoulou, Lukas Roell

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Abstract Background and Hypothesis Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) is associated peripheral inflammation. However, it unclear whether such an delineates a biologically defined subgroup of SSD. Moreover, remains elusive how ChP linked to brain regions, inflammation Study Design A cross-sectional cohort 132 SSD 107 age-matched healthy controls (HC) underwent magnetic resonance imaging (MRI) the clinical phenotyping investigate regions. Case-control comparison volumes was conducted structural variance analysed by employing variability ratio (VR). K-means clustering analysis used identify subgroups distinct patterns ventricular system clusters were compared terms demographic, immunological measures. The relationship between previously inflammation, investigated. Results We could not find significant HC but detected increased VR lateral ventricle volumes. Based on these regions we identified 3 differences age, symbol coding test scores possibly inflammatory markers. Larger volume higher hippocampus, putamen, thalamus SSD, HC. Conclusions This study suggests variability, mean volume,

Language: Английский

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions DOI Open Access

Anton Shkundin,

Angelos Halaris

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 488 - 488

Published: May 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Language: Английский

Citations

7
Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study DOI Creative Commons
Zhengyang Zhao, Jiashuo Zhang, Yulu Wu

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 120, P. 430 - 438

Published: June 17, 2024

Recent studies have associated immune abnormalities with dementia. IL-6 is a crucial cytokine in inflammatory responses, and recent evidence has linked elevated levels to changes brain structure cognitive decline. However, the connection between levels, cognition, volumes, dementia risk requires exploration large prospective cohorts.

Language: Английский

Citations

5
Elevated serum kynurenic acid in individuals with first-episode psychosis and insufficient response to antipsychotics DOI Creative Commons
Alexandros Hatzimanolis,

Stefania Foteli,

Lida‐Alkisti Xenaki

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 10, 2024

Abstract The tryptophan-metabolizing kynurenine pathway (KP) can be activated by enhanced inflammatory responses and has been implicated in the pathophysiology of schizophrenia. However, there is little evidence for KP dysregulation early course psychotic illness. We aimed to investigate potential immune-mediated hyperactivity individuals with first-episode psychosis (FEP) relationship symptom severity treatment response outcomes. Serum immunoassays were performed measure peripheral levels cytokines (IL-1β, IL-10, TNF-a), rate-limiting enzymes (IDO/TDO), kynurenic acid (KYNA) metabolite 104 antipsychotic-naïve patients FEP 80 healthy controls (HC). Positive Negative Syndrome Scale (PANSS) Global Assessment Functioning (GAF) administered assess psychopathology functioning status at admission following 4-week antipsychotics. Cytokine components substantially increased compared HC, before after antipsychotic treatment. A significant positive correlation between pro-inflammatory IL-1β KYNA was observed among patients, but not HC. Importantly, within-patient analysis revealed that those higher baseline experienced more severe negative symptoms poorer clinical improvement follow-up. These findings suggest upregulated psychosis, likely through induction IL-1β-dependent pathways, raised might represent a promising indicator non-response medication FEP.

Language: Английский

Citations

4
Shared Molecular Signature in Alzheimer's Disease and Schizophrenia: A Systematic Review of the Reelin Signaling Pathway DOI Creative Commons

Ana Isabel Valderrama-Mantilla,

Celia Martín-Cuevas, Ana Gómez-Garrido

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106032 - 106032

Published: Jan. 31, 2025

Language: Английский

Citations

0
A Systematic Review of the Effects of EEG Neurofeedback on Patients with Schizophrenia DOI Open Access

Dan Cătălin Oprea,

Iasmin Mawas,

Cătălina Andreea Moroșan

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 763 - 763

Published: July 18, 2024

Schizophrenia is a neuropsychiatric disorder affecting approximately 1 in 300 people worldwide. It characterized by range of symptoms, including positive symptoms (delusions, hallucinations, and formal thought disorganization), negative (anhedonia, alogia, avolition, asociality, blunted affect), cognitive impairments (impaired memory, attention, executive function, processing speed). Current treatments, such as psychopharmacology psychotherapy, often do not fully address these leading to impaired everyday functionality. In recent years, there has been growing interest neuromodulation due computer engineering science making extraordinary computational advances. Those put together have reinitiated the spark field neurofeedback (NF) means for self-regulation with potential alleviate daily burden schizophrenia. We review, systematic way, primary reports electroencephalogram (EEG)-based NF therapeutical tool The main body research consists mostly case studies reports. results few randomized controlled studies, combined studies/series, underscore use an add-on treatment option improving lives suffering individuals, being sustained changes brain function symptomatology improvement. aim provide important evidence using patients schizophrenia, summarizing effects conclusions found several clinical trials.

Language: Английский

Citations

2
Inflammation Proteomic Profiling of Psychosis in Young Adults: Findings from the ALSPAC Birth Cohort DOI Creative Commons
Ruby S. M. Tsang, Nicholas J. Timpson, Golam M. Khandaker

et al.

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 171, P. 107188 - 107188

Published: Sept. 19, 2024

Language: Английский

Citations

2
Investigating the shared genetic basis and causal relationships between mucosa-associated lymphoid tissue inflammation and psychiatric disorders DOI Creative Commons
Andrea Georgiou, Konstantinos Voskarides, Panos Zanos

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: April 29, 2024

Background Chronic and acute inflammation of the mucosa-associated lymphoid tissue have been positively linked to development psychiatric disorders in observational studies. However, it remains unclear whether this association is causal. In present study, we investigated association, using as proxies genetically predicted tonsillectomy, appendectomy appendicitis on including major depressive disorder (MDD), schizophrenia (SCZ), bipolar depression (BD) anxiety (ANX) via a two-sample Mendelian randomization (MR) analysis. Methods Genetic summary statistics for were sourced from FinnGen Consortium, comprising data 342,000 participants. correlations between all exposures outcome calculated with Linkage Disequilibrium Score (LDSC) Regression MR estimates then assess their impact risk developing disorders. Sensitivity analysis was employed test any directional pleiotropy. Results Our results suggest that there no direct causal or heightened The robustness main further confirmed additional sensitivity analyses. moderate inverse genetic correlation observed tonsillectomy MDD traits (r g =-0.39, p-value (P)=7.5x10 -5 ). Conclusion findings provide, first time, evidence subsequent vulnerability Future studies larger sample size GWAS should focus unraveling confounding factors mediators investigate relationship further.

Language: Английский

Citations

1
The Role of Neuroglia in the Development and Progression of Schizophrenia DOI Creative Commons

Neha S. Rawani,

Allen W. Chan,

Kathryn G. Todd

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 10 - 10

Published: Dec. 25, 2024

Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed explain the etiology of schizophrenia have focused largely on dysfunction neurotransmitters such as dopamine, serotonin glutamate with their receptors, although research in past several decades has indicated strongly that other factors are also involved role neuroglial cells psychotic disorders including should given more attention. Although glia were originally present brain only support neurons physical, metabolic nutritional capacity, it become apparent these variety important physiological roles abnormalities function may make significant contributions symptoms schizophrenia. In paper, we review microglia, astrocytes oligodendroglia aspects transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, gut microbiome, myelination blood-brain barrier appear affect cause, development treatment We crosstalk oligodendrocytes effects antipsychotics neuroglia. Problems associated studies specific biomarkers for discussed.

Language: Английский

Citations

1
Inflammation Proteomic Profiling of Psychosis in Young Adults: findings from the ALSPAC birth cohort DOI Creative Commons
Ruby S. M. Tsang, Nicholas J. Timpson, Golam M. Khandaker

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Abstract Psychotic disorder is associated with altered levels of various inflammatory markers in blood, but existing studies have typically focused on a few selected biomarkers, not examined specific symptom domains notably negative symptoms, and are based individuals established/chronic illness. Based data from young people aged 24 years the Avon Longitudinal Study Parents Children (ALSPAC), UK birth cohort, we associations 67 plasma immune/inflammatory proteins assayed using Olink Target 96 Inflammation panel psychotic disorder, positive (any experiences definite experiences) linear models empirical Bayes estimation. The analyses included between 2641 2854 individuals. After adjustment for age, sex, body mass index smoking correction multiple testing, upregulation CDCP1 IL-6 were consistently symptoms while was additionally MMP-10. Negative highest number (n=11), including cytokines, chemokines growth factors which partly overlap or (CDCP1, MMP-10). Our findings highlight involved immune regulation, cell activation/migration, blood-brain barrier disruption, extracellular matrix abnormalities psychosis people, consistent role inflammation dysfunction pathogenesis disorders.

Language: Английский

Citations

0
Interleukin-8 is a Potential Inflammation Biomarker in Major Depressive Disorder DOI Creative Commons

Julia L. Versel,

Adriana Cantos,

Monica Feliz R. Castillo

et al.

Journal of Affective Disorders Reports, Journal Year: 2024, Volume and Issue: 17, P. 100828 - 100828

Published: July 1, 2024

The neuroinflammatory hypothesis of Major Depressive Disorder (MDD) postulates that dysregulated cytokine production is implicated in the etiopathology disorder. This study aimed to determine baseline levels Interleukin-8 (IL-8), an inflammatory cytokine, MDD and identify possible changes response antidepressant drug therapy. Two independent groups patients who met criteria were enrolled; one group was treated with Escitalopram other Quetiapine for twelve weeks. There a healthy control (HC) group. In 30 completed visit 43 patients. Plasma concentrations IL-8 measured at baseline, week eight, 12 treatment. correlated depression severity 12. sample size analysis 17 completers study, 21 19 HCs. We used Student's t-test Pearson Correlation Coefficient statistical analyses. exhibited elevated compared controls (p = 0.007). However, did not show significant reduction after weeks treatment significantly either or there notable downtrend both though statistically significant. Study limitations include variations power, length. No formal assessment conducted rule out Axis II diagnoses. These findings underscore relationship between MDD, suggesting may play role pathophysiology but its requires prolonged period suggests as pro-inflammatory biomarker, while lack immediate normalization post-treatment indicates need further exploration delayed effects therapy on immune markers IL-8′s mechanism action specific pharmacotherapies MDD.

Language: Английский

Citations

0