Advances in photosensitizer-related design for photodynamic therapy DOI Creative Commons

Zhaojie Zhou,

Ling Zhang,

Zhirong Zhang

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2021, Volume and Issue: 16(6), P. 668 - 686

Published: May 2, 2021

Photodynamic therapy (PDT) is highly effective in treating tumors located near body surface, offering strong tumor suppression and low damage to normal tissue nearby. PDT also for a number of other conditions. not only provide precise selective method the treatment various diseases by itself, it can be used combination with traditional therapies. Because uses light as unique targeting mechanism, has simpler more direct capability than The core material system photosensitizer which converts energy therapeutic factors/substances. Different photosensitizers have their distinct characteristics, leading different advantages disadvantages. These could enhanced or compensated using proper system. Therefore, selected type would heavily influence overall design In this article, we evaluated major types inorganic organic photosensitizers, discussed future research directions field.

Language: Английский

Advances in nanomaterials for photodynamic therapy applications: Status and challenges DOI
Jianming Chen, Taojian Fan, Zhongjian Xie

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 237, P. 119827 - 119827

Published: Jan. 27, 2020

Language: Английский

Citations

627
Layered double hydroxide-based nanomaterials for biomedical applications DOI
Tingting Hu, Zi Gu, Gareth R. Williams

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6126 - 6176

Published: Jan. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Language: Английский

Citations

259
Cationic intermediates assisted self-assembly two-dimensional Ti3C2T /rGO hybrid nanoflakes for advanced lithium-ion capacitors DOI

Sha Yi,

Leizhi Wang, Xiong Zhang

et al.

Science Bulletin, Journal Year: 2021, Volume and Issue: 66(9), P. 914 - 924

Published: Jan. 10, 2021

Language: Английский

Citations

191
Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics DOI Creative Commons
Atanu Naskar, Kwang-sun Kim

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(6), P. 499 - 499

Published: May 30, 2020

Nanomaterial-based wound healing has tremendous potential for treating and preventing infections with its multiple benefits compared traditional treatment approaches. In this regard, the physiochemical properties of nanomaterials enable researchers to conduct extensive studies on wound-healing applications. Nonetheless, issues concerning use in accelerating efficacy existing medical treatments remain unresolved. The present review highlights novel approaches focusing recent innovative strategies infection controls based nanomaterials, including nanoparticles, nanocomposites, scaffolds, which are elucidated detail. addition, as carriers therapeutic agents associated applications been addressed. Finally, nanomaterial-based scaffolds their premise future have described. We believe that in-depth analytical review, insights, challenges described herein will provide an up-to-date reference nanomedicine can enhance

Language: Английский

Citations

184
A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration DOI
Zehui Lv, Tingting Hu, Yixin Bian

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

Citations

151
Biomedical engineering of two-dimensional MXenes DOI
Hui Huang, Caihong Dong, Wei Feng

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 184, P. 114178 - 114178

Published: Feb. 26, 2022

Language: Английский

Citations

124
Solid-State Reaction Synthesis of Nanoscale Materials: Strategies and Applications DOI
Amit Kumar, Soumen Dutta, Seonock Kim

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(15), P. 12748 - 12863

Published: June 17, 2022

Nanomaterials (NMs) with unique structures and compositions can give rise to exotic physicochemical properties applications. Despite the advancement in solution-based methods, scalable access a wide range of crystal phases intricate is still challenging. Solid-state reaction (SSR) syntheses have high potential owing their flexibility toward multielemental under feasibly temperatures solvent-free conditions as well scalability simplicity. Controlling nanoscale features through SSRs demands strategic nanospace-confinement approach due risk heat-induced reshaping sintering. Here, we describe advanced SSR strategies for NM synthesis, focusing on mechanistic insights, novel phenomena, underlying principles using series examples different categories. After introducing history classical SSRs, key theories, definitions central topic, categorize various modern based surrounding solid-state media used nanostructure growth, conversion, migration nanospace or dimensional confinement. This comprehensive review will advance quest new materials design,

Language: Английский

Citations

101
Two-Dimensional Nanomaterials beyond Graphene for Biomedical Applications DOI Creative Commons

Maryam Derakhshi,

Sahar Daemi,

Pegah Shahini

et al.

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(1), P. 27 - 27

Published: March 9, 2022

Two-dimensional (2D) nanomaterials (e.g., graphene) have shown to a high potential in future biomedical applications due their unique physicochemical properties such as unusual electrical conductivity, biocompatibility, large surface area, and extraordinary thermal mechanical properties. Although the of graphene most common 2D has been extensively investigated, practical use other nanoengineered materials beyond transition metal dichalcogenides (TMDs), topological insulators (TIs), phosphorene, antimonene, bismuthene, metal–organic frameworks (MOFs) MXenes for not appreciated so far. This review highlights only opportunities various research areas bioelectronics, imaging, drug delivery, tissue engineering, regenerative medicine but also addresses risk factors challenges ahead from medical perspective clinical translation materials. In conclusion, perspectives roadmap are outlined applications.

Language: Английский

Citations

99
Nanocomposite hydrogels for biomedical applications DOI Creative Commons

Shanghui Huang,

Xiangqian Hong, Mingyi Zhao

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 7(3)

Published: April 2, 2022

Nanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in field of nanomedicine. However, nanomaterials do possess disadvantages that cannot ignored, such as burst release, rapid elimination, poor bioadhesion. Hydrogels are scaffolds with three-dimensional structures, exhibit good biocompatibility drug release capacity. also associated for biomedical applications anti-tumor capability, weak bioimaging limited responsiveness, so on. Incorporating into 3D hydrogel network through physical or chemical covalent action may an effective method to avoid disadvantages. In nanocomposite systems, multifunctional often work function core, giving hydrogels a variety properties (such photo-thermal conversion, magnetothermal conductivity, targeting tumor, etc.). While, effectively improve retention effect make nanoparticles have plasticity adapt various biosensors). Nanocomposite systems broad application prospects biomedicine. this review, we comprehensively summarize discuss most recent advances composite biomedicine, including cell delivery, cancer treatment, tissue regeneration, biosensing, bioimaging, briefly discussed current situation commoditization

Language: Английский

Citations

97
A Review on Low-Dimensional Nanomaterials: Nanofabrication, Characterization and Applications DOI Creative Commons

Paras,

Kushal Yadav,

Prashant Kumar

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 13(1), P. 160 - 160

Published: Dec. 29, 2022

The development of modern cutting-edge technology relies heavily on the huge success and advancement nanotechnology, in which nanomaterials nanostructures provide indispensable material cornerstone. Owing to their nanoscale dimensions with possible quantum limit, possess a high surface-to-volume ratio, rich surface/interface effects, distinct physical chemical properties compared bulk counterparts, leading remarkably expanded horizons applications. Depending degree spatial quantization, low-dimensional are generally categorized into nanoparticles (0D); nanorods, nanowires, nanobelts (1D); atomically thin layered materials (2D). This review article provides comprehensive guide nanostructures. It begins classification nanomaterials, followed by an inclusive account nanofabrication characterization. Both top-down bottom-up fabrication approaches discussed detail. Next, various significant applications discussed, such as photonics, sensors, catalysis, energy storage, diverse coatings, bioapplications. would serve quick facile for scientists engineers working field nanotechnology nanomaterials.

Language: Английский

Citations

83