A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

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Nanocomposite hydrogels for biomedical applications

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 7(3)

Published: April 2, 2022

Nanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in field of nanomedicine. However, nanomaterials do possess disadvantages that cannot ignored, such as burst release, rapid elimination, poor bioadhesion. Hydrogels are scaffolds with three-dimensional structures, exhibit good biocompatibility drug release capacity. also associated for biomedical applications anti-tumor capability, weak bioimaging limited responsiveness, so on. Incorporating into 3D hydrogel network through physical or chemical covalent action may an effective method to avoid disadvantages. In nanocomposite systems, multifunctional often work function core, giving hydrogels a variety properties (such photo-thermal conversion, magnetothermal conductivity, targeting tumor, etc.). While, effectively improve retention effect make nanoparticles have plasticity adapt various biosensors). Nanocomposite systems broad application prospects biomedicine. this review, we comprehensively summarize discuss most recent advances composite biomedicine, including cell delivery, cancer treatment, tissue regeneration, biosensing, bioimaging, briefly discussed current situation commoditization

Language: Английский

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Super strong and tough anisotropic hydrogels through synergy of directional freeze-casting, metal complexation and salting out

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 463, P. 142414 - 142414

Published: March 15, 2023

Language: Английский

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Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564

Published: Jan. 1, 2024

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.

Language: Английский

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Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150403 - 150403

Published: March 16, 2024

Hydrogels have emerged in various biomedical applications, including tissue engineering and medical devices, due to their ability imitate the natural extracellular matrix (ECM) of tissues. However, conventional static hydrogels lack dynamically respond changes surroundings withstand robust biophysical microenvironment trigger on-demand functionality such as drug release mechanical change. In contrast, multifunctional dynamic can adapt external stimuli drawn great attention recent studies. It is realized that integration nanomaterials into provides numerous functionalities for a variety applications cannot be achieved by hydrogels. This review article comprehensive overview advances designing fabricating applications. We describe different types based on breakable reversible covalent bonds well noncovalent interactions. These mechanisms are described detail useful reference crosslinking strategies strongly influence properties also discuss use potential benefits. further explores nanocomposite hydrogels, delivery, engineering, bioadhesives, wound healing, cancer treatment, mechanistic study, multiple-scale Finally, we challenges future perspectives field diverse technologies.

Language: Английский

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Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 874 - 874

Published: March 8, 2023

Wounds are alterations in skin integrity resulting from any type of trauma. The healing process is complex, involving inflammation and reactive oxygen species formation. Therapeutic approaches for the wound diverse, associating dressings topical pharmacological agents with antiseptics, anti-inflammatory, antibacterial actions. Effective treatment must maintain occlusion moisture site, suitable capacity absorption exudates, gas exchange, release bioactives, thus stimulating healing. However, conventional treatments have some limitations regarding technological properties formulations, such as sensory characteristics, ease application, residence time, low active penetration skin. Particularly, available may efficacy, unsatisfactory hemostatic performance, prolonged duration, adverse effects. In this sense, there significant growth research focusing on improving wounds. Thus, soft nanoparticles-based hydrogels emerge promising alternatives to accelerate due their improved rheological increased bioadhesiveness, greater permeation, controlled drug release, a more pleasant aspect comparison forms. Soft nanoparticles based organic material natural or synthetic source include liposomes, micelles, nanoemulsions, polymeric nanoparticles. This scoping review describes discusses main advantages nanoparticle-based process. Herein, state-of-the-art presented by addressing general aspects process, current status non-encapsulated drug-based hydrogels, formed different polymers containing nanostructures Collectively, presence performance bioactive compounds employed healing, demonstrating scientific advances obtained so far.

Language: Английский

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Tofacitinib combined with melanocyte protector α-MSH to treat vitiligo through dextran based hydrogel microneedles

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 305, P. 120549 - 120549

Published: Jan. 6, 2023

Language: Английский

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Exploring the potential applications of amphiphilic carbon dots based nanocomposite hydrogel in liquid chromatographic separations

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1299, P. 342445 - 342445

Published: March 4, 2024

Language: Английский

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Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 28, 2024

Abstract Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with relatively low toxicity, they have long been considered for application repressing progression. Traditional containing a single or few discrete epitopes failed the clinic, possibly due to challenges epitope selection, target downregulation, cell heterogeneity, microenvironment immunosuppression, lack of vaccine immunogenicity. Whole membrane vaccines, which provide rich source antigens, are emerging as viable alternatives. Autologous and allogenic cellular evaluated clinical treatments. Tumor membranes (TCMs) an intriguing antigen source, membrane‐accessible targets and, at same time, serve integrated carriers adjuvants other agents. This review provides summary properties technologies TCM vaccines. Characteristics, categories, mechanisms, preparation methods discussed, demonstrable additional benefits derived from combining chemotherapy, sonodynamic therapy, phototherapy, oncolytic viruses. Further research chemistry, biomedicine, immunology, bioinformatics address current drawbacks could facilitate adoption

Language: Английский

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Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 14, 2024

Abstract This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D‐material integrated hydrogels, with a focus on their performance bone‐related applications. Various synthesis methods types 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, MXene are discussed, along strategies for incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical high surface area, strong near‐infrared (NIR) photon absorption controlled release capabilities, making them suitable range regeneration therapeutic In cancer therapy, 2D‐material‐based show promise photothermal photodynamic therapies, drug delivery (chemotherapy). The properties these materials enable selective tumor ablation upon NIR irradiation, while drug‐loading capacity facilitates targeted chemotherapeutic agents. Additionally, 2D‐materials ‐infused potent antibacterial activity, effective against multidrug‐resistant infections disruption biofilm generated implant surface. Moreover, synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, immunotherapy to enhance outcomes. bio‐imaging, serve versatile contrast agents imaging probes, enabling real‐time monitoring during imaging. Furthermore, bone regeneration, most incorporated promote osteogenesis tissue offering potential solutions defects repair. Overall, integration presents promising platform developing multifunctional theragenerative biomaterials.

Language: Английский

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