Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1079 - 1114
Published: Jan. 1, 2024
Hydrogels,
formed
from
crosslinked
hydrophilic
macromolecules,
provide
a
three-dimensional
microenvironment
that
mimics
the
extracellular
matrix.
They
served
as
scaffold
materials
in
regenerative
medicine
with
an
ever-growing
demand.
However,
hydrogels
composed
of
only
organic
components
may
not
fully
meet
performance
and
functionalization
requirements
for
various
tissue
defects.
Composite
hydrogels,
containing
inorganic
components,
have
attracted
tremendous
attention
due
to
their
unique
compositions
properties.
Rigid
particles,
rods,
fibers,
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: May 6, 2024
Abstract
Diabetic
foot
ulcers
(DFUs),
a
serious
and
increasingly
common
chronic
issue
among
diabetics,
often
do
not
respond
well
to
generalized
treatment
strategies.
Hypoxia
the
overexpression
of
reactive
oxygen
species
(ROS),
resulting
in
inflammatory
dysregulation
subsequent
imbalance
macrophage
phenotypes,
are
critical
factors
contributing
prolonged
non‐healing
DFU
wounds.
These
two
issues
interact
continuous,
problematic
cycle.
Presently,
there
is
lack
comprehensive
strategies
aimed
at
addressing
both
these
simultaneously
interrupt
this
detrimental
Herein,
an
immunomodulatory
hydrogel
(PHG2)
developed
for
reshaping
hostile
microenvironment.
The
engineered
PHG2
only
removes
excess
internally‐produced
ROS
but
also
generates
O
2
,
with
its
efficiency
further
boosted
by
local
hyperthermia
(42.5
°C)
activated
near‐infrared
light.
Through
vitro
vivo
studies,
along
transcriptomic
assessment,
it
confirmed
that
disrupts
feedback
loop
between
inflammation
while
lowering
M1/M2
ratio.
Such
discoveries
contribute
significant
enhancement
healing
process
injuries
undergo
gradual
increase
movement,
covering
wounds
from
back,
mouth,
foot.
Ultimately,
method
provides
easy,
safe,
highly
effective
solution
treating
DFUs.
Rapid
and
effective
repair
of
injured
or
diseased
bone
defects
remains
a
major
challenge
due
to
shortages
implants.
Smart
hydrogels
that
respond
internal
external
stimuli
achieve
therapeutic
actions
in
spatially
temporally
controlled
manner
have
recently
attracted
much
attention
for
therapy
regeneration.
These
can
be
modified
by
introducing
responsive
moieties
embedding
nanoparticles
increase
their
capacity
repair.
Under
specific
stimuli,
smart
variable,
programmable,
controllable
changes
on
demand
modulate
the
microenvironment
promoting
healing.
In
this
review,
we
highlight
advantages
summarize
materials,
gelation
methods,
properties.
Then,
overview
recent
advances
developing
biochemical
signals,
electromagnetic
energy,
physical
including
single,
dual,
multiple
types
enable
physiological
pathological
modulating
microenvironment.
discuss
current
challenges
future
perspectives
regarding
clinical
translation
hydrogels.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(31)
Published: Sept. 14, 2023
Abstract
Although
CeO
2
nanomaterials
have
been
widely
explored
as
nanozymes
for
catalytic
therapy,
they
still
suffer
from
relatively
low
activities.
Herein,
the
catalyzing
generation
and
stabilization
of
oxygen
vacancies
on
nanorods
by
Pt
nanoclusters
via
H
gas
reduction
under
mild
temperature
(350
°C)
to
obtain
Pt/CeO
2−
x
,
which
can
serve
a
highly
efficient
nanozyme
cancer
is
reported.
The
deposited
atomic
layer
deposition
technique
not
only
catalyst
generate
through
hydrogen
spillover
effect,
but
also
stabilize
generated
vacancies.
Meanwhile,
provide
anchoring
sites
forming
strong
metal‐support
interactions
thus
preventing
their
agglomerations.
Importantly,
reduced
at
350
°C
(Pt/CeO
‐350R)
exhibits
excellent
enzyme‐mimicking
activity
reactive
species
(e.g.,
·OH)
compared
other
control
samples,
including
temperatures,
achieving
performance
tumor‐specific
therapy
efficiently
eliminate
cells
in
vitro
ablate
tumors
vivo.
‐350R
originates
good
activities
vacancy‐rich
nanoclusters.
Small,
Journal Year:
2024,
Volume and Issue:
20(24)
Published: Jan. 2, 2024
Abstract
In
view
of
the
increased
levels
reactive
oxygen
species
(ROS)
that
disturb
osteogenic
differentiation
bone
marrow
mesenchymal
stem
cells
(BMSCs),
repair
diabetic
defects
remains
a
great
challenge.
Herein,
factor‐free
hydrogel
is
reported
with
ROS
scavenging
and
responsive
degradation
properties
for
enhanced
healing.
These
hydrogels
contain
ROS‐cleavable
thioketal
(TK)
linkers
ultraviolet
(UV)‐responsive
norbornene
(NB)
groups
conjugated
8‐arm
PEG
macromers,
which
are
formed
via
UV
crosslinking‐mediated
gelation.
Upon
reacting
high
in
defect
microenvironment,
TK
destroyed,
allowing
hydrogels,
promotes
migration
BMSCs.
Moreover,
reduced
through
hydrogel‐mediated
to
reverse
BMSC
from
adipogenic
phenotype.
As
such,
favorable
microenvironment
created
after
simultaneous
degradation,
leading
effective
mouse
models,
even
without
addition
growth
factors.
Thus,
this
study
presents
platform
regulates
stromal
engineering.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(20)
Published: March 19, 2024
Abstract
Layered
double
hydroxides
(LDHs)
have
been
widely
studied
for
biomedical
applications
due
to
their
excellent
properties,
such
as
good
biocompatibility,
degradability,
interlayer
ion
exchangeability,
high
loading
capacity,
pH‐responsive
release,
and
large
specific
surface
area.
Furthermore,
the
flexibility
in
structural
composition
ease
of
modification
LDHs
makes
it
possible
develop
specifically
functionalized
meet
needs
different
applications.
In
this
review,
recent
advances
applications,
which
include
LDH‐based
drug
delivery
systems,
cancer
diagnosis
therapy,
tissue
engineering,
coatings,
functional
membranes,
biosensors,
are
comprehensively
discussed.
From
these
various
research
fields,
can
be
seen
that
there
is
great
potential
possibility
use
However,
at
same
time,
must
recognized
actual
clinical
translation
still
very
limited.
Therefore,
current
limitations
related
on
discussed
by
combining
limited
examples
with
requirements
biomaterials.
Finally,
an
outlook
future
provided.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: Feb. 23, 2024
Abstract
Autophagy,
a
lysosome‐involved
degradation
pathway,
as
self‐protective
cellular
process,
always
weakens
the
efficiency
of
tumor
therapies.
Herein,
for
first
time,
biodegradable
copper
(Cu)
ions
doped
layered
double
hydroxide
(Cu‐LDH)
nanoparticles
are
reported
cancer
immunotherapy
via
lysosomal
rupture‐mediated
“Broken
Window
Effect”.
Only
injection
Cu‐LDH
single
therapeutic
agent
achieves
various
organelles
destruction
after
rupture,
well
abnormal
aggregation
Cu
in
cells
cuproptosis
and
pyroptosis.
More
importantly,
autophagy
inhibition
caused
by
rupture
improves
overload‐mediated
pyroptosis
blocking
lysosome‐mediated
bulk
leading
to
good
anti‐tumor
immune
responses
ultimately
high‐efficiency
growth
inhibition.
This
Effect”
provides
new
paradigm
enhanced
therapy.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 348 - 377
Published: April 23, 2024
Setting
time
as
the
fourth
dimension,
4D
printing
allows
us
to
construct
dynamic
structures
that
can
change
their
shape,
property,
or
functionality
over
under
stimuli,
leading
a
wave
of
innovations
in
various
fields.
Recently,
smart
biomaterials,
biological
components,
and
living
cells
into
3D
constructs
with
effects
has
led
an
exciting
field
bioprinting.
bioprinting
gained
increasing
attention
is
being
applied
create
programmed
cell-laden
such
bone,
cartilage,
vasculature.
This
review
presents
overview
on
for
engineering
tissues
organs,
followed
by
discussion
approaches,
technologies,
biomaterials
design,
bioink
requirements,
applications.
While
much
progress
been
achieved,
complex
process
facing
challenges
need
be
addressed
transdisciplinary
strategies
unleash
full
potential
this
advanced
biofabrication
technology.
Finally,
we
present
future
perspectives
rapidly
evolving
bioprinting,
view
its
potential,
increasingly
important
roles
development
basic
research,
pharmaceutics,
regenerative
medicine.
