International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131950 - 131950
Published: April 28, 2024
Language: Английский
Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582
Published: Feb. 16, 2023
Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.
Language: Английский
Citations
198
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 821 - 834
Published: Jan. 30, 2023
Language: Английский
Citations
67
Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 206 - 221
Published: March 21, 2024
With the development of nanomedicine, nanomaterials have been widely used, offering specific drug delivery to target sites, minimal side effects, and significant therapeutic effects. The kidneys filtration reabsorption functions, with various potential cell types a complex structural environment, making strategies for kidney function protection recovery after injury complex. This also lays foundation application nanomedicine in diseases. Currently, evidence preclinical clinical settings supports feasibility targeted therapy diseases using based on nanomaterials. prerequisite treating is use carriers good biocompatibility, including nanoparticles, hydrogels, liposomes, micelles, dendrimer polymers, adenoviruses, lysozymes, elastin-like polypeptides. These precise renal uptake, longer half-life, organ distribution, protecting improving efficacy drugs they carry. Additionally, attention should be paid toxicity solubility carriers. While mentioned above used studies both vivo vitro, extensive trials are still needed ensure short-term long-term effects nano human body. review will discuss advantages limitations nanoscale carrier materials diseases, provide more comprehensive catalog nanocarrier materials, offer prospects their drug-loading applications.
Language: Английский
Citations
39
Gels, Journal Year: 2022, Volume and Issue: 8(10), P. 606 - 606
Published: Sept. 21, 2022
Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit survival regeneration. In recent years, application macroporous has received considerable attention. The structure not only facilitates nutrient transportation metabolite discharge but also provides more space behavior formation. Several strategies creating functionalizing reported. This review began with an overview advantages challenges regulation cellular behavior. addition, advanced methods preparation modulate were discussed. Finally, future research related fields was
Language: Английский
Citations
65
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(51), P. 56525 - 56534
Published: Dec. 15, 2022
Biomedical dressings have been comprehensively explored for wound healing; however, the complicated manufacturing process and mono-function of dressing remain critical challenges further applications. Here, a versatile extrusion three-dimensional (3D) printing strategy to prepare MXene spidroin-incorporated microneedle scaffolds with photothermal responsive self-healing properties promoting healing is proposed. Inspired by cactus, scaffold composed top porous scaffold, microneedles whose inverse opal (IO) photonic crystal (PC) structure ample space between gaps endow high drug-carrying capacity. Furthermore, excellent electrical allow perform sensitive movement monitoring controlled drug release under near-infrared irradiation. Moreover, extensive hydrogen bonding Schiff base spidroin, polyurethane (PU), aloe vera gel (avGel) molecules conferred mechanical performance scaffold. In vivo experiments rat models wounds shown that drug-laden (NIR) light can promote recovery full-skin wounds. These unique characteristics suggest 3D-printed multifunctional show great potential applications in facilitating will find widespread management.
Language: Английский
Citations
53
Advanced Science, Journal Year: 2023, Volume and Issue: 11(9)
Published: Dec. 20, 2023
Abstract Treating the most widespread complication of diabetes: diabetic wounds poses a significant clinical obstacle due to intricate nature wound healing in individuals with diabetes. Here novel approach is proposed using easily applicable injectable gelatin/metal/tea polyphenol double nanonetworks, which effectively remodel microenvironment and accelerates process. The gelatin(Gel) crosslink metal ions (Zr 4+ ) through amino acids, imparting advantageous mechanical properties like self‐healing, injectability, adhesion. nanonetwork's biological functions are further enhanced by incorporating tea nanonetwork situ doping epigallocatechin gallate (EGCG) great antibacterial, antioxidant, anticancer capabilities. vitro vivo tests show that this nanonetworks hydrogel exhibits faster cell migration favorable anti‐inflammatory antioxidant can greatly reshape accelerate rate. In addition, completely degraded after subcutaneous injection for 7 d ays , nondetectable cytotoxicity H&E staining major mice organs serum level liver function indicators. Considering above‐mentioned merits hydrogel, it believed have broad biomedical potential, especially repair tissue engineering.
Language: Английский
Citations
43
Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(12), P. 4226 - 4237
Published: Jan. 1, 2023
A self-healing antibacterial hydrogel was fabricated for accelerating infected wound healing. This possesses biocompatible, self-healing, and antibiotic-free properties, thus is promising as a dressing.
Language: Английский
Citations
34
Science Bulletin, Journal Year: 2023, Volume and Issue: 68(8), P. 826 - 837
Published: March 21, 2023
Language: Английский
Citations
34
Advanced Science, Journal Year: 2023, Volume and Issue: 11(5)
Published: Nov. 30, 2023
Abstract Developing biomaterials with antimicrobial and wound‐healing activities for the treatment of wound infections remains challenging. Macrophages play non‐negligible roles in healing infection‐related wounds. In this study, a new sequential immunomodulatory approach is proposed to promote effective rapid using novel hybrid hydrogel dressing based on immune characteristics bacteria‐associated The substrate derived from porcine dermal extracellular matrix (PADM) loaded class bioactive glass nanoparticles (BGns) doped copper (Cu) zinc (Zn) ions (Cu–Zn BGns). This demonstrates controlled release Cu 2+ Zn sequentially regulates phenotypic transition macrophages M1 M2 by alternately activating nucleotide‐binding oligomerization domain (NOD) inhibiting mitogen‐activated protein kinases (MAPK) signaling pathways. Additionally, its dual‐temporal bidirectional function facilitates enhanced antibacterial activity healing. Hence, capable safely efficiently accelerating during infections. As such, design strategy provides direction exploring address current clinical challenges related
Language: Английский
Citations
30
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 315, P. 120973 - 120973
Published: May 5, 2023
Language: Английский
Citations
24