Defining the role of omics in assessing ecosystem health: Perspectives from the Canadian environmental monitoring program

Environmental Toxicology and Chemistry, Journal Year: 2015, Volume and Issue: 35(1), P. 20 - 35

Published: Dec. 3, 2015

Abstract Scientific reviews and studies continue to describe omics technologies as the next generation of tools for environmental monitoring, while cautioning that there are limitations obstacles overcome. However, has not yet transitioned into national monitoring programs designed assess ecosystem health. Using example Canadian Environmental Effects Monitoring (EEM) program, authors steps would be required included in such an established program. These include baseline collection endpoints across different species sites generate a range what is biologically normal within particular ecosystem. Natural individual variability omes adequately characterized often measured field, but key component determine critical effect size or action threshold management. Omics must develop level standardization, consistency, rigor will allow interpretation relevance changes broader scales. To date, population‐level consequences routinely reduced gonad intersex fish entirely clear, significance genome‐wide molecular, proteome, metabolic on organism population health further removed from levels ecological change traditionally managed. The present review intended dismiss idea play future role large‐scale studies, rather outlines necessary actions its inclusion regulatory focused assessing Environ Toxicol Chem 2016;35:20–35. © 2015 SETAC

Language: Английский

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High contaminant loads in Lake Apopka's riparian wetland disrupt gene networks involved in reproduction and immune function in largemouth bass

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2016, Volume and Issue: 19, P. 140 - 150

Published: June 22, 2016

Language: Английский

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Oxidative stress responses in relationship to persistent organic pollutant levels in feathers and blood of two predatory bird species from Pakistan

The Science of The Total Environment, Journal Year: 2016, Volume and Issue: 580, P. 26 - 33

Published: Dec. 8, 2016

Language: Английский

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Impaired antioxidant gene expression by pesticide residues and its relation with other cellular biomarkers in Nile Tilapia (Oreochromis niloticus) from Lake Burullus

Ecotoxicology and Environmental Safety, Journal Year: 2016, Volume and Issue: 137, P. 202 - 209

Published: Dec. 19, 2016

Language: Английский

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An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters

Water Research, Journal Year: 2017, Volume and Issue: 131, P. 33 - 44

Published: Dec. 11, 2017

Language: Английский

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Biochemical and Transcriptomic Effects of Herring Gull Egg Extracts from Variably Contaminated Colonies of the Laurentian Great Lakes in Chicken Hepatocytes

Environmental Science & Technology, Journal Year: 2015, Volume and Issue: 49(16), P. 10190 - 10198

Published: July 20, 2015

Determining the effects of complex mixtures environmental contaminants poses many challenges within field ecotoxicology. In this study, graded concentrations herring gull egg extracts, collected from five Great Lakes breeding colonies with variable burdens organohalogen (OHCs), were administered to chicken embryonic hepatocytes determine on 7-ethoxyresorufin-O-deethylase (EROD) activity, porphyrin accumulation, and mRNA expression. EROD activity accumulation permitted ranking based efficacy eliciting an aryl hydrocarbon receptor-mediated response. An avian ToxChip polymerase chain reaction (PCR) array provided more exhaustive coverage in terms potential toxicity pathways being affected, including xenobiotic lipid metabolism thyroid hormone pathway. Herring eggs Channel Shelter Island (CHSH, Lake Huron) Gull (GULL, Michigan) had among highest OHC burdens, extracts elicited a biochemical transcriptomic response greater than that other three, less polluted colonies. For example, EC50 values ECthreshold lower for CHSH GULL Extracts altered 15 13 27 genes PCR compared no eight contaminated sites. The combination well-established vitro assay, two well-characterized assays, geographical discrimination variably Lakes. Such high-throughput assays show promise as cost-effective tools determining toxic potencies environment.

Language: Английский

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A survey of benthic sediment contaminants in reaches of the Columbia River Estuary based on channel sedimentation characteristics

The Science of The Total Environment, Journal Year: 2014, Volume and Issue: 484, P. 331 - 343

Published: April 3, 2014

Language: Английский

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Transcriptome discovery in non-model wild fish species for the development of quantitative transcript abundance assays

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2016, Volume and Issue: 20, P. 27 - 40

Published: July 15, 2016

Language: Английский

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Transcriptomic, lipid, and histological profiles suggest changes in health in fish from a pesticide hot spot

Marine Environmental Research, Journal Year: 2018, Volume and Issue: 140, P. 299 - 321

Published: June 30, 2018

Language: Английский

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Transcriptional response of yellow perch to changes in ambient metal concentrations—A reciprocal field transplantation experiment

Aquatic Toxicology, Journal Year: 2016, Volume and Issue: 173, P. 132 - 142

Published: Feb. 1, 2016

Language: Английский

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