Antimicrobial Resistance: a One Health Perspective

Microbiology Spectrum, Journal Year: 2018, Volume and Issue: 6(2)

Published: March 30, 2018

ABSTRACT One Health is the collaborative effort of multiple health science professions to attain optimal for people, domestic animals, wildlife, plants, and our environment. The drivers antimicrobial resistance include use abuse in human, animal, environmental sectors spread resistant bacteria determinants within between these around globe. Most classes antimicrobials used treat bacterial infections humans are also animals. Given important interdependent dimensions resistance, it logical take a approach when addressing this problem. This includes taking steps preserve continued effectiveness existing by eliminating their inappropriate limiting infection. Major concerns animal agriculture mass medication animals with that critically humans, such as third-generation cephalosporins fluoroquinolones, long-term, in-feed medically antimicrobials, colistin, tetracyclines, macrolides, growth promotion. In human sector essential prevent infections, reduce over-prescribing improve sanitation, hygiene infection control. Pollution from inadequate treatment industrial, residential, farm waste expanding resistome Numerous countries several international agencies have included action plans address resistance. Necessary actions improvements regulation policy, surveillance, stewardship, control, husbandry, alternatives antimicrobials. WHO recently has launched new guidelines on food-producing recommending farmers food industry stop using routinely promote disease healthy These aim help medicine reducing

Language: Английский

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Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance

Environment International, Journal Year: 2018, Volume and Issue: 117, P. 132 - 138

Published: May 7, 2018

There is growing understanding that the environment plays an important role both in transmission of antibiotic resistant pathogens and their evolution. Accordingly, researchers stakeholders world-wide seek to further explore mechanisms drivers involved, quantify risks identify suitable interventions. a clear value establishing research needs coordinating efforts within across nations order best tackle this global challenge. At international workshop late September 2017, scientists from 14 countries with expertise on environmental dimensions resistance gathered define critical knowledge gaps. Four key areas were identified where urgently needed: 1) relative contributions different sources antibiotics bacteria into environment; 2) environment, particularly anthropogenic inputs, evolution resistance; 3) overall human animal health impacts caused by exposure bacteria; 4) efficacy feasibility technological, social, economic behavioral interventions mitigate resistance.1.

Language: Английский

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One Health—Its Importance in Helping to Better Control Antimicrobial Resistance

Tropical Medicine and Infectious Disease, Journal Year: 2019, Volume and Issue: 4(1), P. 22 - 22

Published: Jan. 29, 2019

Approaching any issue from a One Health perspective necessitates looking at the interactions of people, domestic animals, wildlife, plants, and our environment. For antimicrobial resistance this includes use (and abuse) in human, animal environmental sectors. More importantly, spread resistant bacteria determinants within between these sectors globally must be addressed. Better managing problem taking steps to preserve continued effectiveness existing antimicrobials such as trying eliminate their inappropriate use, particularly where they are used high volumes. Examples mass medication animals with critically important for humans, third generation cephalosporins fluoroquinolones, long term, in-feed antimicrobials, colistin, tetracyclines macrolides, growth promotion. In people it is essential better prevent infections, reduce over-prescribing over-use stop spreading by improving hygiene infection control, drinking water sanitation. Pollution inadequate treatment industrial, residential farm waste expanding resistome Numerous countries several international agencies have now included Approach action plans address resistance. Necessary actions include improvements regulation policy, well improved surveillance, stewardship, sanitation, husbandry, finding alternatives antimicrobials.

Language: Английский

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Prevalence of ESKAPE pathogens in the environment: Antibiotic resistance status, community-acquired infection and risk to human health

International Journal of Hygiene and Environmental Health, Journal Year: 2022, Volume and Issue: 244, P. 114006 - 114006

Published: July 1, 2022

The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pathogens are characterised by increased levels of resistance towards multiple classes first line last-resort antibiotics. Although these frequently isolated from clinical environments implicated in a variety life-threatening, hospital-associated infections; antibiotic resistant strains have been environmental reservoirs such as surface water, wastewater, food, soil. Literature on the persistence subsequent health risks posed isolates extra-hospital settings is however, limited current review aims to elucidate primary environment, their profiles, link community-acquired infections. Additionally, information state research regarding health-risk assessments linked exposure natural outlined.

Language: Английский

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Environmental contamination in a high-income country (France) by antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes: Status and possible causes

Environment International, Journal Year: 2021, Volume and Issue: 159, P. 107047 - 107047

Published: Dec. 16, 2021

Antimicrobial resistance (AMR) is a major global public health concern, shared by large number of human and animal actors. Within the framework One Health approach, actions should be implemented in environmental realm, as well realms. The Government France commissioned report to provide policy decision makers with an evidential basis for recommending or taking future mitigate AMR environment. We first examined mechanisms that underlie emergence persistence antimicrobial This drew up inventory contamination aquatic terrestrial environments antibiotics, anticipating findings will representative some other high-income countries. Effluents wastewater treatment plants were identified source on French territory, spreading organic waste products more diffuse incidental environments. A limitation this review heterogeneity available data space time, lack certain sources. Comparing Measured Environmental Concentrations (MECs) predicted no effect concentrations (PNECs), fluoroquinolones trimethoprim representing high medium risk favoring selection resistant bacteria treated most contaminated rivers. All antibiotic molecules analyzed (erythromycin, clarithromycin, azithromycin, tetracycline) at low those However, impairs their full exploitation. Consequently, we listed indicators survey antibiotics environment recommended harmonization sampling strategies endpoints analyses. Finally, objectives methods used present work could comprise useful example how national authorities countries sharing common socio-geographic characteristics seek better understand define dimension particular settings.

Language: Английский

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A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

Analytical Methods, Journal Year: 2021, Volume and Issue: 13(5), P. 575 - 594

Published: Jan. 1, 2021

Active pharmaceutical ingredients (APIs) are increasingly being identified as contaminants of emerging concern (CECs).

Language: Английский

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Wastewater treatment plants, an “escape gate” for ESCAPE pathogens

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: May 24, 2023

Antibiotics are an essential tool of modern medicine, contributing to significantly decreasing mortality and morbidity rates from infectious diseases. However, persistent misuse these drugs has accelerated the evolution antibiotic resistance, negatively impacting clinical practice. The environment contributes both transmission resistance. From all anthropically polluted aquatic environments, wastewater treatment plants (WWTPs) probably main reservoirs resistant pathogens. They should be regarded as critical control points for preventing or reducing release antibiotics, antibiotic-resistant bacteria (ARB), antibiotic-resistance genes (ARGs) into natural environment. This review focuses on fate pathogens Enterococcus faecium , Staphylococcus aureus Clostridium difficile Acinetobacter baumannii Pseudomonas aeruginosa Enterobacteriaceae spp. (ESCAPE) in WWTPs. All ESCAPE pathogen species, including high-risk clones resistance determinants last-resort antibiotics such carbapenems, colistin, multi-drug platforms, were detected wastewater. whole genome sequencing studies demonstrate clonal relationships dissemination Gram-negative species via hospital effluents enrichment virulence S. enterococci Therefore, efficiency different processes regarding removal clinically relevant ARB ARGs, well influence water quality factors their performance, explored monitored, along with development more effective treatments appropriate indicators (ESCAPE and/or ARGs). knowledge will allow standards point sources consolidate WWTP barrier role against environmental public health AR threats.

Language: Английский

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Antibiotic resistance in urban and hospital wastewaters and their impact on a receiving freshwater ecosystem

Chemosphere, Journal Year: 2018, Volume and Issue: 206, P. 70 - 82

Published: April 30, 2018

Language: Английский

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Class 1 integrons as invasive species

Current Opinion in Microbiology, Journal Year: 2017, Volume and Issue: 38, P. 10 - 15

Published: April 14, 2017

Language: Английский

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Antimicrobial Resistance: a One Health Perspective

ASM Press eBooks, Journal Year: 2018, Volume and Issue: unknown, P. 521 - 547

Published: Aug. 23, 2018

Antimicrobial resistance is a global public health crisis that threatens our ability to successfully treat bacterial infections (1, 2). Microbiologists and infectious disease specialists have long recognized the problem—the discoverer of penicillin Sir Alexander Fleming himself drew attention threat from underdosing (3)—but realization vast scale resistant only now reaching wider audiences. Many agents could once be treated with any one several drug classes acquired most, in some cases, virtually all these drugs (4, 5). The most acute for antibiotics synthetic antibacterial antimicrobial agents, focus this paper, but also threatened are antifungals, antiparasitics, antivirals (6). How did we get point where antimicrobials were truly "wonder drugs" relied upon cure wide range life-threatening today, widely prevalent supply new has dwindled trickle? complete answer not simple, nor unfortunately, solution. One thing seems certain: overuse precious multiple sectors (human, animal, agriculture) main problem must addressed 7).

Language: Английский

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