Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(5)
Published: April 11, 2025
Language: Английский
The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 733, P. 139186 - 139186
Published: May 4, 2020
Language: Английский
Citations
198
Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 55(11), P. 7510 - 7520
Published: May 13, 2021
This is the first study in last 15 years to analyze per- and polyfluoroalkyl substances (PFAS) breast milk collected from mothers (n = 50) United States, our findings indicate that both legacy current-use PFAS now contaminate milk, exposing nursing infants. Breast was analyzed for 39 PFAS, including 9 short-chain 30 long-chain compounds, 16 of these were detected 4-100% samples. The ∑PFAS concentration ranged 52.0 1850 pg/mL with a median 121 pg/mL. Perfluorooctanesulfonic acid (PFOS) perfluorooctanoic (PFOA) most abundant samples (medians 30.4 13.9 pg/mL, respectively). Two perfluoro-n-hexanoic (PFHxA, C6) perfluoro-n-heptanoic (PFHpA, C7), concentrations 9.69 6.10 respectively. Analysis available data around world over period 1996-2019 showed while levels phased-out PFOS PFOA have been declining halving times 8.1 17 years, respectively, detection frequencies increasing doubling time 4.1 years.
Language: Английский
Citations
187
Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 407, P. 124863 - 124863
Published: Dec. 17, 2020
Language: Английский
Citations
146
Frontiers in Toxicology, Journal Year: 2022, Volume and Issue: 4
Published: April 11, 2022
Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that chemically stable, resistant to degradation, persistent in terrestrial aquatic environments. Widespread use PFAS industrial processing manufacturing over the last 70 years has led global contamination built natural The brain is lipid rich highly vascularized organ composed long-lived neurons glial cells especially vulnerable impacts lipophilic toxicants. Generally, partition protein-rich tissues body, primarily liver blood, but also detected brains humans, wildlife, laboratory animals. Here we review factors impacting absorption, distribution, accumulation brain, currently available evidence for neurotoxic defined by disruption neurochemical, neurophysiological, behavioral endpoints. Emphasis placed on potential exposures during critical periods development sensitive populations, may exacerbate neurotoxicity PFAS. While limitations inconsistencies across studies exist, body suggests neurobehavioral long-chain more pronounced than resulting from exposure adulthood. There paucity experimental evaluating molecular mechanisms short-chain PFAS, even greater data gaps analysis outside perfluoroalkyl acids. Whereas most were focused acute subchronic high dose single congener, realistic humans wildlife mixtures relatively chronic low nature. Our evaluation human epidemiological, experimental, indicates heightened acids after environmental exposure, comparison studies. These findings highlight need additional neurodevelopmental environmentally relevant concentrations complex
Language: Английский
Citations
83
Environment International, Journal Year: 2022, Volume and Issue: 162, P. 107149 - 107149
Published: Feb. 28, 2022
Human exposure to per- and polyfluoroalkyl substances (PFAS) has been primarily attributed contaminated food drinking water. There is information indicating other sources pathways of in residential environments, but few studies report relationships between these indoor media human biomonitoring measurements. This study adapts existing systematic review tools methodologies synthesize evidence for PFAS from environment including consumer products, household articles, cleaning personal care air dust. Studies were identified using innovative machine learning approaches pathway-specific search strings reduce time needed literature screening. The included evaluated modified specifically studies. was conducted following a previously published protocol (DeLuca et al., 2021) that describes the methodology used detail. Only 7 measured targeted subset 8 chemicals concordant (primarily house dust) participant serum. Data extracted calculate intake rates estimate percentage occupant serum concentrations could be pathways. These calculations showed PFOA, PFOS, PFNA, PFHxS dust account 13%, 3%, 7%, 25% concentrations, respectively. Inhalation less than 4% PFOA 2% PFOS PFNA concentrations. A risk bias due profiles most being skewed towards white, female, higher socioeconomic status. Along with synthesizing estimated contributions levels media, this also identifies consistent across populations should considered future It highlights major research gap need measure data both continued on modeling parameters many chemicals.
Language: Английский
Citations
74
Environmental Research, Journal Year: 2023, Volume and Issue: 242, P. 117743 - 117743
Published: Nov. 25, 2023
Per- and polyfluoroalkyl substances (PFAS) constitute a heterogeneous group of synthetic compounds widely used in industrial applications. The estimation PFAS half-life (t1/2) is essential to quantify their persistence, toxicity mechanism action humans. purpose this review summarize the evidence on half-lives humans from available literature, investigate limitations uncertainties characterizing estimation. search was conducted PubMed, Scopus, Embase databases up July 03, 2023 aimed at identifying all papers that estimated human populations. We excluded studies temporal trends or providing estimates based solely renal clearance. As persistent ongoing exposures can influence estimation, we decided include only were after main source exposure had ceased. A random-effects meta-analysis reported perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS) perfluorohexanesulfonic (PFHxS) Risk bias evaluated using OHAT tool. total 13 articles included review, with 5 exposed general populations 8 workers; mean ranged 1.48 5.1 years for PFOA, 3.4 5.7 PFOS, 2.84 8.5 PFHxS. High heterogeneity among observed; potential reasons variability investigated populations, discrepancies considering exposures, isomeric compositions, accounting background exposure, time since stopped methods Despite efforts made better understand toxicokinetics, further are needed identify important characteristics these chemicals. Biomonitoring should focus unaccounted sources individual potentially determining half-life, ensure accurate estimates.
Language: Английский
Citations
69
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 17, 2024
Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.
Language: Английский
Citations
45
Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 9, P. 100623 - 100623
Published: Jan. 14, 2024
Alarming concern over the persistence and toxicity of per- polyfluoroalkyl substances (PFAS) in environment has created an imperative need for designing redesigning strategies their detection remediation. Conventional PFAS removal technologies that uses physical, chemical, or biological methods. Increase diversity quantity entering necessitated developing more advanced integrated removal. Despite advances reported this domain, there exist a huge research gap to be mentored tackle problems associated with mitigation combined wide variety environment. The possibility combine other emerging contaminants poses additional threat existing treatment methods thereby stressing continuous monitoring updating processes. This review work aims at understanding structure, entry, fate different types Further in-depth discussion regarding levels is elaborated review. process description recent remediation techniques along significance, limitations integration discussed detail. detailed outlook on advantages insight into recently developed outlined
Language: Английский
Citations
26
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(13), P. 5670 - 5684
Published: March 19, 2024
PFASs are linked to serious health and environmental concerns. Among their widespread applications, known be used in food packaging directly contribute human exposure. However, information about is scattered. Therefore, we systematically map the evidence on detected migrates extracts of contact materials provide an overview available hazard biomonitoring data. Based FCCmigex database, 68 have been identified various materials, including paper, plastic, coated metal, by targeted untargeted analyses. 87% these belong perfluorocarboxylic acids fluorotelomer-based compounds. Trends chain length demonstrate that long-chain perfluoroalkyl continue found, despite years global efforts reduce use substances. We utilized ToxPi illustrate data for only 57% packaging. For those which toxicity testing has performed, many adverse outcomes reported. The knowledge gaps presented here support international proposals restrict as a group, protect health.
Language: Английский
Citations
22
Toxicology Reports, Journal Year: 2024, Volume and Issue: 12, P. 436 - 447
Published: April 6, 2024
Per- and polyfluoroalkyl substances (PFAS) have been used in industrial consumer applications for ages. The pervasive persistent nature of PFAS the environment is a universal concern due to public health risks. Experts acknowledge that exposure high levels certain consequences, including reduced vaccine efficacy, elevated cholesterol, increased risk blood pressure. While considerable research has conducted investigate presence environment, pathways human through food packaging/contact materials (FCM) remain unclear. In this review, we present an exhaustive overview dietary PFAS. Also, mechanism migration from FCMs into occurrence foods were considered. Further, analytical techniques matrices as well impacts. recent regulatory actions working set standards guidelines packaging highlighted. Alternative being developed evaluated their safety efficacy contact applications, offering promising alternatives also Finally, reported on general considerations perspectives presently
Language: Английский
Citations
20