genesis,
Journal Year:
2021,
Volume and Issue:
59(11)
Published: Nov. 1, 2021
Abstract
Fetal
alcohol
spectrum
disorder
(FASD)
describes
a
wide
range
of
structural
deficits
and
cognitive
impairments.
FASD
impacts
up
to
5%
children
born
in
the
United
States
each
year,
making
ethanol
one
most
common
teratogens.
Due
limitations
ethical
concerns,
studies
humans
are
limited
their
ability
study
FASD.
Animal
models
have
proven
critical
identifying
characterizing
mechanisms
underlying
In
this
review,
we
will
focus
on
attributes
zebrafish
that
make
it
strong
model
which
ethanol‐induced
developmental
defects.
Zebrafish
several
an
ideal
produced
large
numbers
externally
fertilized,
translucent
embryos.
With
high
degree
genetic
amenability,
at
forefront
gene‐ethanol
interactions
underlie
Work
from
multiple
labs
has
shown
embryonic
exposures
result
defects
craniofacial,
cardiac,
ocular,
neural
development.
addition
defects,
behavioral
impairments
been
studied
zebrafish.
Building
upon
these
studies,
work
identified
ethanol‐sensitive
loci
However,
analyses
show
there
is
still
much
be
learned
interactions.
The
ideally
suited
expand
our
understanding
impact
Because
conservation
gene
function
between
humans,
directly
translate
candidate
genes
human
populations
allow
for
better
diagnosis
treatment
Molecules,
Journal Year:
2020,
Volume and Issue:
25(6), P. 1318 - 1318
Published: March 13, 2020
Commiphora
myrrh
resin
(Myrrh)
has
been
used
in
traditional
Arabic
medicine
to
treat
various
inflammatory
diseases.
Two
furano-sesquiterpenoids,
2-methoxyfuranodiene
(CM1)
and
2-acetoxyfuranodiene
(CM2),
were
isolated
from
the
chloroform
fraction
of
ethanolic
extract
resin.
The
cytotoxicity
compounds
was
evaluated
using
human
liver
carcinoma,
breast
cancer
cells
(HepG2
MCF-7,
respectively)
normal
umbilical
vein
endothelial
(HUVECs)
cell
lines.
development
toxicity
anti-angiogenic
activity
both
also
zebrafish
embryos.
Cell
survival
assays
demonstrated
that
highly
cytotoxic
HepG2
MCF7
cells,
with
IC50
values
3.6
4.4
µM,
respectively.
Both
induced
apoptosis
caused
cycle
arrest
treated
which
observed
flow
cytometric
analysis.
embryos
showed
chronic
compounds.
only
seen
when
remained
exposed
for
more
than
three
days.
compound
CM2
a
significant
level
transgenic
at
sublethal
doses.
Thus,
we
properties
compounds,
suggesting
molecular
mechanism
these
should
be
further
assessed.
Journal of Ecohydraulics,
Journal Year:
2024,
Volume and Issue:
9(2), P. 248 - 258
Published: Jan. 31, 2024
A
fundamental
assumption
in
animal
telemetry
is
that
the
behavior
and
performance
of
tagged
animals
do
not
substantially
deviate
from
untagged
animals.
For
fish,
swimming
for
every
part
a
fish
post-hatch
life,
influencing
predator-prey
interactions,
movement
ecology,
habitat
choice.
Here,
we
study
effects
PIT-tagging
on
survival
range
behaviors
South
European
nase
(Protochondrostoma
genei)
brook
barbel
(Barbus
caninus),
two
small-sized,
stream-dwelling
cypriniforms
native
to
Italian
peninsula.
Effects
volitional
activity
(sustained
swimming)
maximum
speed
(escape
response;
burst
were
tested
arena
trials.
Tagging
prolonged
an
increasing
velocity
time-to-fatigue
test,
while
barrier
passage
test
was
designed
further
investigate
tagging
barbel.
Both
species
displayed
very
high
(95–100%),
with
no
difference
between
control
fish.
No
lost
tag
during
64
days
study,
effect
activity,
performance,
rate,
or
escape
response
detected.
Our
results
indicate
PIT-telemetry
suitable
tool
species.
Environmental Science & Technology,
Journal Year:
2022,
Volume and Issue:
56(17), P. 12380 - 12390
Published: Aug. 19, 2022
Residual
antidepressants
are
of
increasing
concern
worldwide,
yet
critical
information
on
their
long-term
neurotoxic
impacts
nontarget
aquatic
animals
is
lacking.
Here,
we
investigated
the
effects
(from
0
to
150
days
postfertilization)
selective
serotonin
reuptake
inhibitor
citalopram
(0.1–100
μg/L)
motor
function,
learning,
and
memory
in
zebrafish
over
two
generations
explored
reversibility
effect
F1
larvae.
Unlike
F0+
larvae,
found
that
F1+
larvae
displayed
decreased
sensorimotor
performance
when
continuously
exposed
at
100
μg/L.
No
adverse
were
F1–
after
they
transferred
a
clean
medium.
Whole-mount
immunofluorescence
assays
suggested
impairments
related
axonal
projections
spinal
neurons
(MNs).
For
adults,
exposure
mainly
caused
male-specific
declines
motor,
performance.
Analysis
serotonergic
cholinergic
MNs
revealed
no
significant
changes
male
cord.
In
contrast,
number
glutamatergic
decreased,
likely
associated
with
impairment
function.
Additionally,
treatment
μg/L
significantly
reduced
dopaminergic
neurons,
but
neuronal
apoptosis
was
observed
adult
telencephalon.
Overall,
this
study
provides
neurobehavioral
evidence
novel
insights
into
mechanisms
may
facilitate
assessment
environmental
health
risks
posed
by
citalopram-containing
antidepressant
drugs.
Behavioural Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
Cannabidiol
(CBD)
was
first
isolated
in
the
1940s
and
its
drug
structure
established
1960s.
It
has
risen
significantly
popularity
since
then
been
observed
to
reduce
inflammation
anxiety
patients.
CBD
is
easy
obtain
consume,
therefore,
common
use
rising
spread
pets
children.
Few
studies
have
focused
on
of
as
a
solution
aggression.
In
our
study,
we
tested
if
effective
reducing
aggression
Siamese
fighting
fish
(Betta
splendens)
induced
by
territorial
interactions.
Betta
were
exposed
controls
(water
or
acetone)
treatments
ranging
from
low,
medium,
high
(2,
10,
20
mg
CBD/L,
respectively),
their
behaviors
after
visual
introduction
an
intruder
recorded.
reduced
odds
aggressive
behavior
treated
fish.
Seventy-five
percent
all
control
exhibited
behaviors,
while
only
17%
CBD-treated
displayed
Especially,
low
dose
seemed
at
preventing
but
also
appeared
more
lethargic
than
any
other
treatments.
However,
when
did
not
appear
amount
time
spent
being
compared
that
receive
treatment.
While
long-term
effects
still
be
examined,
study
indicates
might
potentially
pets.
