Priority Screening of Contaminants of Emerging Concern (Cecs) in Surface Water: Comparing Cell-Based Bioassays and Exposure-Activity Ratios (Ears) DOI

John P. Vanden Heuvel,

Megan Granda,

Francesca M. Ferguson

et al.

Published: Jan. 1, 2024

In this study, we compared a wide range of cell-based bioassays to the use chemical analysis followed by exposure-activity ratio (EAR) and Toxicological Prioritization index (ToxPi) for prioritizing chemicals, sites, hazard concerns in water samples. Surface samples were collected from nine sites three Central Pennsylvania streams analyzed targeted list compounds emerging concern (CECs), including pesticides, personal care products, pharmaceuticals. Cell-based reporter assays evaluated human zebrafish molecular initiating events (MIEs) endocrine metabolic disruption, altered lipid metabolism, oxidative stress. Bioassays showed that 29 out 40 had at least one site with activity over limit detection. The receptors exhibited highest number above effect-based trigger (EBT) values would be expected cause toxicity Aryl hydrocarbon receptor (AhR, zebrafish), Pregnane X Receptor (PXR), Estrogen Receptor-beta (ERB), Androgen (AR). Characterizing collection their bioactivity aligned closely stream which collected, Warriors Mark Run, Halfmoon, Spruce Run more similar than other streams. sum all EARs each indicated pharmaceutical Carbamazepine pesticides Carbaryl Atrazine posed greatest concern. However, predicted prioritization based on individual calculated EAR different those measured bioassay, indicating biologically active chemicals are present not included analytes. Taken together, these data show beneficial whereas mechanism-based inclusive known as well unknown contaminants thus overall quality prioritization.

Language: Английский

Evaluating the potential role of bioactive chemicals on the distribution of invasive Asian carp upstream and downstream from river mile 278 in the Illinois waterway DOI Creative Commons
William A. Battaglin, James J. Duncker, Paul J. Terrio

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 735, P. 139458 - 139458

Published: May 16, 2020

Language: Английский

Citations

22
Reconnaissance of cumulative risk of pesticides and pharmaceuticals in Great Smoky Mountains National Park streams DOI
Paul M. Bradley,

Matt A. Kulp,

Bradley J. Huffman

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 781, P. 146711 - 146711

Published: March 25, 2021

Language: Английский

Citations

18
Risk‐Based Prioritization of Organic Chemicals and Locations of Ecological Concern in Sediment From Great Lakes Tributaries DOI
Austin K. Baldwin, Steven R. Corsi, Owen M. Stefaniak

et al.

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 41(4), P. 1016 - 1041

Published: Jan. 12, 2022

Abstract With improved analytical techniques, environmental monitoring studies are increasingly able to report the occurrence of tens or hundreds chemicals per site, making it difficult identify most relevant from a biological standpoint. For present study, organic chemical was examined, individually and as mixtures, in context potential effects. Sediment collected at 71 Great Lakes (USA/Canada) tributary sites analyzed for 87 chemicals. Multiple risk‐based lines evidence were used prioritize locations, including comparing sediment concentrations estimated porewater with established whole‐organism benchmarks (i.e., water quality criteria screening values) high‐throughput toxicity data US Environmental Protection Agency's ToxCast database, estimating additive effects mixtures on common endpoints, toxic equivalencies alkylphenols polycyclic aromatic hydrocarbons (PAHs). This multiple‐lines‐of‐evidence approach enabled more chemicals, mitigated uncertainties individual approaches, strengthened conclusions. Collectively, least one benchmark/screening value exceeded 54 exceedances observed all sites. Chemicals greatest effects, both mixture components, bisphenol A, 4‐nonylphenol, indole, carbazole, several PAHs. Potential adverse outcomes based gene targets putative outcome pathways included tumors, skewed sex ratios, reproductive dysfunction, hepatic steatosis, early mortality, among others. The results provide screening‐level prioritization an indication where they likely occur. Environ Toxicol Chem 2022;41:1016–1041. Published 2022. article is U.S. Government work public domain USA. Toxicology Chemistry published by Wiley Periodicals LLC behalf SETAC.

Language: Английский

Citations

13
Epilithic biofilms as a discriminating matrix for long-term and growing season pesticide contamination in the aquatic environment: Emphasis on glyphosate and metabolite AMPA DOI
Gracieli Fernandes, Virginia Aparicio, Eduardo De Gerónimo

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 900, P. 166315 - 166315

Published: Aug. 19, 2023

Language: Английский

Citations

7
Levels and ecological risk of selected organic pollutants in the high-altitude alpine cryosphere - The Adamello-Brenta Natural Park (Italy) as a case study DOI Creative Commons
C. Rizzi, Sara Villa, Luca Rossini

et al.

Environmental Advances, Journal Year: 2022, Volume and Issue: 7, P. 100178 - 100178

Published: Jan. 22, 2022

Language: Английский

Citations

12
Trace Organic Contaminants in U.S. National Park Surface Waters: Prevalence and Ecological Context DOI Creative Commons
Sarah Elliott,

Kerensa A. King,

Aliesha L. Krall

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125006 - 125006

Published: Sept. 1, 2024

Language: Английский

Citations

2
Prioritizing Pesticides of Potential Concern and Identifying Potential Mixture Effects in Great Lakes Tributaries Using Passive Samplers DOI Creative Commons
Luke C. Loken, Steven R. Corsi, David A. Alvarez

et al.

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 42(2), P. 340 - 366

Published: Sept. 27, 2022

To help meet the objectives of Great Lakes Restoration Initiative with regard to increasing knowledge about toxic substances, 223 pesticides and pesticide transformation products were monitored in 15 tributaries using polar organic chemical integrative samplers. A screening-level assessment their potential for biological effects was conducted by computing toxicity quotients (TQs) chemicals available US Environmental Protection Agency (USEPA) Aquatic Life Benchmark values. In addition, exposure activity ratios (EAR) calculated information from USEPA ToxCast database. Between 16 81 detected per site, 97 unique compounds overall, which 64 could be assessed TQs or EARs. Ten exceeded TQ EAR levels concern at two more sites. Chemicals exceeding thresholds included seven herbicides (2,4-dichlorophenoxyacetic acid, diuron, metolachlor, acetochlor, atrazine, simazine, sulfentrazone), a product (deisopropylatrazine), insecticides (fipronil imidacloprid). Watersheds draining agricultural urban areas had detections higher concentrations compared other land uses. Chemical mixtures analysis assays associated common modes action defined gene targets adverse outcome pathways (AOP) indicated on related range cellular processes, including xenobiotic metabolism, extracellular signaling, endocrine function, protection against oxidative stress. Use ontology databases AOP knowledgebase within R-package ToxMixtures highlighted utility data identifying evaluating outcomes mixtures. Results have provided list high-priority future monitoring warranting further evaluation laboratory field environments. Environ Toxicol Chem 2023;42:340-366. Published 2022. This article is U.S. Government work public domain USA. Toxicology Chemistry published Wiley Periodicals LLC behalf SETAC.

Language: Английский

Citations

10
Priority screening of contaminants of emerging concern in drinking water sources of eastern China: Assessing risks based on exposure-activity ratios (EARs) DOI

Shijiao Ma,

Huiyu Dong,

Ding Li

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 893, P. 164881 - 164881

Published: June 15, 2023

Language: Английский

Citations

6
Predicted aquatic exposure effects from a national urban stormwater study DOI Creative Commons
Paul M. Bradley, Kristin M. Romanok, Kelly L. Smalling

et al.

Environmental Science Water Research & Technology, Journal Year: 2023, Volume and Issue: 9(12), P. 3191 - 3199

Published: Jan. 1, 2023

Episodic stormwater discharges expose aquatic ecosystems to extensive contaminant mixtures. Cumulative acute risks multiple trophic levels are estimated based on mixtures documented in a US reconnaissance.

Language: Английский

Citations

5
Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019) DOI Creative Commons
Lucía Vera-Herrera,

Daniele Sadutto,

Yolanda Picó

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(12), P. 3688 - 3688

Published: June 16, 2021

Background: Pesticide residues are a threat to the health of global population, not only farmers, applicators, and other pesticide professionals. Humans exposed through various routes such as food, skin, inhalation. This study summarizes different methods assess and/or estimate human exposure population. Methods: A systematic search was carried out on Scopus web science databases studies since 2019. Results: The risk can be categorized direct (determining specific biomarkers in matrices) or indirect levels environment food estimating occurrence). role that analytical techniques play analyzed. In both cases, application generic solvent extraction solid-phase (SPE) clean-up, followed by liquid gas chromatography coupled mass spectrometry, is decisive. Advances within have played an unquestionable role. Conclusions: All these contributed important advance knowledge for detection subsequent assessment nonoccupational exposure.

Language: Английский

Citations

11