Analytical and Bioanalytical Chemistry,
Journal Year:
2022,
Volume and Issue:
414(19), P. 5877 - 5886
Published: June 4, 2022
Non-steroidal
anti-inflammatory
drugs
(NSAIDs)
have
been
reported
to
be
the
main
pharmaceutical
class
accumulated
in
seafood.
Among
them,
ibuprofen
(IBU)
is
of
special
concern
as
it
used
worldwide
treat
common
pain,
does
not
require
a
medical
prescription,
often
taken
high
daily
dose,
and
has
cause
potential
adverse
effects
on
aquatic
organisms.
IBU
highly
transformed
into
hydroxy-
carboxy-metabolites
and/or
degradation
products
generated
only
after
its
administration
but
also
during
wastewater
treatment
or
environment.
These
compounds
can
present
environment
at
higher
concentrations
than
toxicity.
In
this
work,
low-cost
affordable
routine
analytical
method
was
developed
validated
for
first-time
determination
metabolites
mussels.
The
based
ultrasound-assisted
extraction
(UAE),
clean-up
by
dispersive
solid-phase
(d-SPE)
liquid
chromatography-tandem
mass
spectrometry.
Box-Behnken
experimental
design
optimisation
better
evaluate
influence
interactions
UAE
d-SPE
variables.
Extraction
recoveries
were
range
from
81
115%.
Precision,
expressed
relative
standard
deviation,
lower
7%.
Method
detection
limits
0.1
1.9
ng
g-1
dry
weight.
successfully
applied
wild
The Science of The Total Environment,
Journal Year:
2022,
Volume and Issue:
861, P. 160638 - 160638
Published: Dec. 5, 2022
There
is
increasing
evidence
that
the
presence
of
certain
pharmaceuticals
in
environment
leads
to
biota
exposure
and
constitute
a
potential
risk
for
ecosystems.
Bioaccumulation
an
essential
focus
assessment
evaluate
at
what
degree
emerging
contaminants
are
hazard
both
individuals
inhabit
it.
The
main
goals
present
review
1)
summarize
describe
research
factors
should
be
taken
into
account
evaluation
bioaccumulation
aquatic
organisms;
2)
provide
database
critical
bioaccumulation/bioconcentration
(BAF
or
BCF)
these
compounds
organisms
different
trophic
levels.
Most
studies
fall
one
two
categories:
laboratory-scale
absorption
purification
tests
field
and,
lesser
extent,
large-scale,
semi-natural
system
tests.
Although
last
5
years
there
has
been
considerable
progress
this
field,
especially
species
fish
molluscs,
still
limited
on
other
like
crustaceans
algae.
This
revision
includes
>230
bioconcentration
(BCF)
>530
(BAF),
determined
113
pharmaceuticals.
most
commonly
studied
antidepressant
group,
followed
by
diclofenac
carbamazepine.
currently
no
reported
accumulation
data
compounds,
such
as
anti-cancer
drugs.
BCFs
highly
influenced
experimental
(notably
level,
time
temperature).
Field
BAFs
superior
laboratory
BCFs,
highlighting
importance
reliable
assessments
true
environmental
conditions.
BAF
appears
organ,
compound-specific.
impact
food
web
transfer
also
considered.
Among
species,
lower
levels
benthic
exhibit
relatively
higher
uptake
compounds.
Environmental Toxicology and Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
Diclofenac
(DCF)
is
a
nonsteroidal
anti-inflammatory
drug
commonly
used
in
health
care,
livestock,
and
pharmaceuticals
widely
detected
surface
water
environments
globally.
Here,
we
reviewed
the
occurrence
characteristics,
migration
pathways,
aquatic
toxicity
of
DCF
environments.
Asian
African
populations
are
exposed
to
high
concentrations
(>
8,000
ng
L−1).
Wastewater
discharge,
industrial
pollution
primary
factors
influencing
concentration
distribution
DCF.
can
cause
acute
toxicity,
oxidative
stress,
other
toxic
effects
on
organisms.
We
focused
China
analyzed
ecological
risks
found
low
risk
south
north,
as
well
during
rainy
season
dry
season.
Finally,
discuss
removal
methods
for
propose
potential
metal-organic
frameworks
new
material
replace
conventional
removal.
This
study
comprehensively
reveals
status
it
poses
environments,
providing
reference
environmental
management
Sensors,
Journal Year:
2021,
Volume and Issue:
21(6), P. 1975 - 1975
Published: March 11, 2021
In
this
work,
a
disposable
electrochemical
(voltammetric)
molecularly
imprinted
polymer
(MIP)
sensor
for
the
selective
determination
of
diclofenac
(DCF)
was
constructed.
The
proposed
MIP-sensor
permits
fast
(30
min)
analysis,
is
cheap,
easy
to
prepare
and
has
potential
be
integrated
with
portable
devices.
Due
its
simplicity
efficiency,
surface
imprinting
by
electropolymerization
used
MIP
on
screen-printed
carbon
electrode
(SPCE).
preparation
achieved
cyclic
voltammetry
(CV),
using
dopamine
(DA)
as
monomer
in
presence
DCF.
differential
pulse
(DPV)
detection
DCF
at
MIP/SPCE
non-imprinted
control
sensors
(NIP)
showed
an
factor
2.5.
Several
experimental
parameters
were
studied
optimized.
CV
impedance
spectroscopy
(EIS)
experiments
performed
evaluate
modifications.
adequate
selectivity
(in
comparison
other
drug
molecules),
intra-day
repeatability
7.5%,
inter-day
11.5%,
linear
range
between
0.1
10
μM
(r2
=
0.9963)
limit
(LOD)
quantification
(LOQ)
70
200
nM,
respectively.
Its
applicability
successfully
demonstrated
spiked
water
samples
(river
tap
water).
Water,
Journal Year:
2022,
Volume and Issue:
14(22), P. 3772 - 3772
Published: Nov. 20, 2022
The
Baltic
Sea
is
a
unique
ecosystem
that
especially
sensitive
to
anthropogenic
pressure.
We
analysed
human
pressure
in
this
sea,
which
may
be
considered
as
paradoxes.
One
of
these,
paradox
“marine”
pollution.
almost
totally
surrounded
by
land
and
therefore
sources
marine
pollution
are
located
mainly
on
the
land.
Another
connected
with
shipping
traffic
intensity
maritime
accidents.
characterised
large
traffic,
but
last
decades’
data
show
only
more
than
100,
usually
insignificant
minor,
accidents
incidents
at
every
year.
Although
relatively
low
native
species
number
compared
most
systems,
it
home
alien
species.
Moreover,
despite
common
opinion
sea
source
living
resources,
available
riches
under
anthropopressure
limited
does
not
give
expected
benefits—it
next
paradox.
fact
warming
rapidly
due
climate
change
suitable
for
bathing
when
weather
favourable,
massive
algae
growth
often
prevents
it.
Therefore,
strong
impact
should
sustainable
use
prioritised.
Environmental Science & Technology,
Journal Year:
2021,
Volume and Issue:
55(12), P. 7920 - 7929
Published: June 4, 2021
The
exposure
of
ecologically
critical
invertebrate
species
to
biologically
active
pharmaceuticals
poses
a
serious
risk
the
aquatic
ecosystem.
Yet,
fate
and
toxic
effects
on
these
nontarget
invertebrates
underlying
mechanisms
are
poorly
studied.
Herein,
we
investigated
toxicokinetic
(TK)
processes
(i.e.,
uptake,
biotransformation,
elimination)
pharmaceutical
diclofenac
its
biotransformation
in
freshwater
Hyalella
azteca.
We
further
employed
mass
spectrometry-based
metabolomics
assess
metabolic
functions
H.
azteca
exposed
environmentally
relevant
concentrations
(10
100
μg/L).
TK
results
showed
quick
uptake
by
(maximum
internal
concentration
1.9
μmol/kg)
rapid
formation
conjugate
taurine
80.6
μmol/kg),
indicating
over
40
times
higher
accumulation
than
that
Depuration
kinetics
demonstrated
elimination
was
64
slower
Metabolomics
suggested
inhibited
prostaglandin
synthesis
affected
carnitine
shuttle
pathway
at
concentrations.
These
findings
shed
light
significance
process
diclofenac,
especially
taurine,
as
well
sublethal
bulk
metabolome
Combining
provides
complementary
insights
thus
better
mechanistic
understanding
invertebrates.
