Occurrence, bioaccumulation, fate, and risk assessment of emerging pollutants in aquatic environments: A review

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 923, P. 171388 - 171388

Published: March 1, 2024

Language: Английский

---

Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(24), P. 8845 - 8862

Published: June 8, 2023

The increasing levels and frequencies at which active pharmaceutical ingredients (APIs) are being detected in the environment of significant concern, especially considering potential adverse effects they may have on nontarget species such as fish. With many pharmaceuticals lacking environmental risk assessments, there is a need to better define understand risks that APIs their biotransformation products pose fish, while still minimizing use experimental animals. There both extrinsic (environment- drug-related) intrinsic (fish-related) factors make fish potentially vulnerable human drugs, but not necessarily captured nonfish tests. This critical review explores these factors, particularly focusing distinctive physiological processes underlie drug absorption, distribution, metabolism, excretion toxicity (ADMET). Focal points include impact life stage absorption (A) via multiple routes; implications fish's unique blood pH plasma composition distribution (D) molecules throughout body; how endothermic nature varied expression activity drug-metabolizing enzymes tissues affect metabolism (M); physiologies relative contribution different excretory organs (E) metabolites. These discussions give insight into where existing data properties, pharmacokinetics pharmacodynamics from mammalian clinical studies or help inform

Language: Английский

---

Recent Progress in Sustainable Treatment Technologies for the Removal of Emerging Contaminants from Wastewater: A Review on Occurrence, Global Status and Impact on Biota

Reviews of Environmental Contamination and Toxicology, Journal Year: 2024, Volume and Issue: 262(1)

Published: July 2, 2024

Language: Английский

---

Water Analysis: Emerging Contaminants and Current Issues

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8184 - 8219

Published: May 3, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWater Analysis: Emerging Contaminants and Current IssuesSusan D. Richardson*Susan RichardsonDepartment of Chemistry Biochemistry, University South Carolina, JM Palms Center for GSR, 631 Sumter Street, Columbia, Carolina 29208, United States*[email protected]More by Susan RichardsonView Biographyhttps://orcid.org/0000-0001-6207-4513 Tarek ManasfiTarek ManasfiEawag, Environmental Chemistry, Uberlandstrasse 133, Dubendorf 8600, SwitzerlandMore ManasfiView BiographyCite this: Anal. Chem. 2024, 96, 20, 8184–8219Publication Date (Web):May 3, 2024Publication History Received16 March 2024Accepted16 April 2024Revised14 2024Published online3 May inissue 21 2024https://pubs.acs.org/doi/10.1021/acs.analchem.4c01423https://doi.org/10.1021/acs.analchem.4c01423review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views826Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Drinking water,Extraction,Impurities,Liquid chromatography,Mass spectrometry Get e-Alerts

Language: Английский

---

A Systematic Review of Pesticide Exposure, Associated Risks, and Long-Term Human Health Impacts

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101840 - 101840

Published: Nov. 30, 2024

Language: Английский

---

Chlorpromazine's impact on Mytilus galloprovincialis: a multi-faceted investigation

Chemosphere, Journal Year: 2023, Volume and Issue: 350, P. 141079 - 141079

Published: Dec. 29, 2023

The antipsychotic chlorpromazine (Cpz) has raised concern as a pharmaceutical effluent due to its wide medical applications. Moreover, potent pro-oxidant properties and impact on the cell viability of marine mollusc Mytilus galloprovincialis, even at low concentrations (ng/L), have been noted. Based this evidence, in study, we investigated physiological effects Cpz M. elucidate fate within organism, terms bioaccumulation, biotransformation, byssus changes stress responses cellular thiolome. Histological indicators vitality analyses were also performed better evaluate influence drug morphology digestive gland. To end, two different (Cpz I (12 ng/L or 37 pM) II μg/L nM)) administered mussels over 14 days. accumulation gland significantly increased with water concentration (BCF II). Biochemical indicated lysosomal dysfunction, reflected elevated total Cathepsin D activity compromised membrane stability. Stress-related metal-buffering proteins (GST metallothionein) responded both concentrations. induced phase biotransformation (CYP450-dependent EROD), while triggered caspase-3 activation, indicative detoxification overload. analysis revealed atrophy, epithelial thinning, haemocyte infiltration, brown presence. Byssus showed significant alterations. In conclusion, our study underscores Cpz-induced histological posing potential implications for mussel health confirming utilisation an indication ecotoxicity.

Language: Английский

---

Environmental Impact of Pharmaceuticals: A Comprehensive Review

Matrix Science Pharma, Journal Year: 2023, Volume and Issue: 7(3), P. 85 - 94

Published: July 1, 2023

Abstract This comprehensive review seeks to evaluate and synthesize the extensive literature regarding environmental impact of pharmaceuticals, a growing area concern within realm science. Pharmaceuticals, including human veterinary medicines, have been detected ubiquitously in environment due their widespread use incomplete removal during wastewater treatment processes. These substances pose potential ecological risks bioactive properties, but magnitude implications these impacts are not yet fully understood. Our covers major aspects such as pathways entry, detection methods, on flora fauna, health pharmaceutical contamination. We further explored effectiveness current technologies removing assess emerging technologies. The concludes by discussing policy necessity for global coordinated response. By encapsulating breadth research this area, we hope spur foster greater awareness waste.

Language: Английский

---

Advanced methods for treating gemfibrozil and carbamazepine in wastewater: a review

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(6), P. 3171 - 3194

Published: July 5, 2024

Abstract The contamination of ecosystems by pharmaceuticals and personal care products represents a significant threat to public health, necessitating innovative approaches clean wastewater before release into aquatic environments. Here, we review the emerging strategies methods for remediation gemfibrozil carbamazepine, emphasizing toxicological impacts, advanced oxidation processes, membrane-based removal techniques, underlying mechanisms driving these processes. We found that engineered composites with strong electron transfer capabilities can enhance efficiency as they boost generation highly oxidative radicals. For instance, nano zero-valent ion incorporated carbon–nitrogen composite removes 100% within 60 min. Similarly, ruthenium perovskite-based heterogeneous catalyst achieved elimination carbamazepine in 7.5

Language: Английский

---

Eco-Friendly Synthesis of Al2O3 Nanoparticles: Comprehensive Characterization Properties, Mechanics, and Photocatalytic Dye Adsorption Study

Coatings, Journal Year: 2024, Volume and Issue: 14(7), P. 848 - 848

Published: July 6, 2024

Metal and metal oxide nanoparticles are gaining traction in inorganic catalysis photocatalysis, driving the development of eco-friendly methods. This study introduces an cost-effective approach for synthesizing Al2O3 (NPs) using extracts derived from leaves Calligonum comosum L. The primary objective this investigation is to assess photocatalytic efficacy synthesized catalyst addressing organic pollutants. NPs exhibit a spherical morphology with crystalline arrangements, as evidenced by average crystallite size 25.1 nm XRD analysis. band gap energy determined be 2.86 eV. In terms mechanical properties, show significant potential enhancing both flexural compressive thereby making them viable choice improving performance composites. Notably, Young’s modulus hybrid composite (comprising plant material NPs) exhibits remarkable increase 34.4% flexion 78.3% compression compared alone. catalytic evaluated methylene blue (MB) cationic dye Rose Bengal (RB) anionic dye. Impressively, demonstrate degradation efficiencies 98.2% MB 90.5% RB. processes occur under solar light irradiation, contact time 120 m, maintained pH 7, temperature 25 °C. found that promising, cost-effective, environmentally friendly option water treatment.

Language: Английский

---

Pharmaceuticals in raw and treated water from drinking water treatment plants nationwide: Insights into their sources and exposure risk assessment

Water Research X, Journal Year: 2024, Volume and Issue: 24, P. 100256 - 100256

Published: Sept. 1, 2024

Due to the large amounts of pharmaceuticals and personal care products (PPCPs) currently being consumed released into environment, this study provides a comprehensive analysis pharmaceutical pollution in both raw treated water from full-scale drinking treatment plants nationwide. Our investigation revealed that 30 out 37 PPCPs were present with mean concentrations ranging 0.01-131 ng/L. The sources, surface (ND - 147 ng/L), subsurface 123 ng/L) reservoir sources 135 exhibited higher concentration levels residues compared groundwater 1.89 ng/L). Meanwhile, water, 17 analyzed carbamazepine, clarithromycin, fluconazole, telmisartan, valsartan, cotinine most common (detection frequency > 40 %), having 1.22, 0.12, 3.48, 40.1, 6.36, 3.73 ng/L, respectively. These findings highlight that, while processes are effective, there some persistent compounds prove challenging fully eliminate. Using Monte Carlo simulations, risk assessment indicated these likely have negligible impact on human health, except for antihypertensives. Telmisartan was identified as posing highest ecological (RQ 1), warranting further investigation, monitoring. concludes by prioritizing specific 14 pharmaceuticals, including lamotrigine, cotinine, lidocaine, tramadol, others, future monitoring safeguard health.

Language: Английский

---