Wastewater surveillance demonstrates high predictive value for COVID-19 infection on board repatriation flights to Australia DOI Creative Commons
Warish Ahmed, Aaron Bivins, Stuart L. Simpson

et al.

Environment International, Journal Year: 2021, Volume and Issue: 158, P. 106938 - 106938

Published: Oct. 15, 2021

Controlling importation and transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from overseas travelers is essential for countries, such as Australia, New Zealand, other island nations, that have adopted a suppression strategy to manage very low community transmission. Wastewater surveillance SARS-CoV-2 RNA has emerged promising tool employed in public health response many countries globally. This study aimed establish whether the aircraft wastewater can be used provide an additional layer information augment individual clinical testing. 37 long-haul flights chartered repatriate Australians was tested presence RNA. Children 5 years or older on these negative disease 19 (COVID-19) (deep nasal oropharyngeal reverse-transcription (RT)-PCR swab) 48 h before departure. All passengers underwent mandatory quarantine 14-day post arrival Howard Springs, NT, Australia. 24 (64.9 %) positive During 14 day quarantine, testing identified 112 cases COVID-19. Surveillance repatriation flight using pooled results three RT-qPCR assays demonstrated predictive value (PPV) 87.5 %, (NPV) 76.9 % 83.7% accuracy COVID-19 during post-arrival period. The successfully demonstrates effective informing management returning monitoring SARS CoV-2 clinically significant pathogens.

Language: Английский

Testing at scale during the COVID-19 pandemic DOI Creative Commons
Tim R. Mercer, Marc Salit

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 22(7), P. 415 - 426

Published: May 4, 2021

Language: Английский

Citations

361
Implementing building-level SARS-CoV-2 wastewater surveillance on a university campus DOI Creative Commons
Cynthia Gibas, Kevin Lambirth, Neha Mittal

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 782, P. 146749 - 146749

Published: March 30, 2021

The COVID-19 pandemic has been a source of ongoing challenges and presents an increased risk illness in group environments, including jails, long-term care facilities, schools, residential college campuses. Early reports that the SARS-CoV-2 virus was detectable wastewater advance confirmed cases sparked widespread interest wastewater-based epidemiology (WBE) as tool for mitigation outbreaks. One hypothesis surveillance might provide cost-effective alternative to other more expensive approaches such pooled random testing groups. In this paper, we report outcomes pilot program at University North Carolina Charlotte, large urban university with substantial population students living on-campus dormitories. Surveillance conducted building level on thrice-weekly schedule throughout university's fall semester. multiple cases, enabled identification asymptomatic were not detected by components campus monitoring program, which also included in-house contact tracing, symptomatic testing, scheduled student athletes, daily symptom reporting. context all cluster events reported community during semester, resulted smaller clusters than types events. Wastewater able detect single individuals dorms resident populations 150-200. While strategy described developed COVID-19, it is likely be applicable future pandemics universities group-living environments.

Language: Английский

Citations

238
Wastewater surveillance to infer COVID-19 transmission: A systematic review DOI Creative Commons
Shimoni Shah, Sylvia Xiao Wei Gwee,

Jamie Qiao Xin Ng

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 804, P. 150060 - 150060

Published: Sept. 8, 2021

Successful detection of SARS-COV-2 in wastewater suggests the potential utility wastewater-based epidemiology (WBE) for COVID-19 community surveillance. This systematic review aims to assess performance surveillance as early warning system transmission. A search was conducted PubMed, Medline, Embase and WBE Consortium Registry according PRISMA guidelines relevant articles published until 31st July 2021. Relevant data were extracted summarized. Quality each paper assessed using an assessment tool adapted from Bilotta et al.'s environmental science. Of 763 studies identified, 92 distributed across 34 countries shortlisted qualitative synthesis. total 26,197 samples collected between January 2020 May 2021 various locations serving population ranging 321 11,400,000 inhabitants. Overall sample positivity moderate at 29.2% all examined settings with spike (S) gene having maximum rate positive detections nucleocapsid (N) being most targeted. Wastewater signals preceded confirmed cases by up 63 days, 13 reporting before first detected community. At least 50 reported association viral load cases. While cannot replace large-scale diagnostic testing, it can complement clinical providing signs transmission more active public health responses. However, standardized validated methods are required along risk analysis modelling understand dynamics outbreaks.

Language: Английский

Citations

187
Targeted wastewater surveillance of SARS-CoV-2 on a university campus for COVID-19 outbreak detection and mitigation DOI Open Access
Laura C. Scott, Alexandra Aubee, Layla Babahaji

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 200, P. 111374 - 111374

Published: May 29, 2021

Language: Английский

Citations

163
Rapid, Large-Scale Wastewater Surveillance and Automated Reporting System Enable Early Detection of Nearly 85% of COVID-19 Cases on a University Campus DOI Creative Commons
Smruthi Karthikeyan, Andrew Nguyen, Daniel McDonald

et al.

mSystems, Journal Year: 2021, Volume and Issue: 6(4)

Published: Aug. 10, 2021

Wastewater-based surveillance has gained prominence and come to the forefront as a leading indicator of forecasting COVID-19 (coronavirus disease 2019) infection dynamics owing its cost-effectiveness ability inform early public health interventions. A university campus could especially benefit from wastewater surveillance, universities are characterized by largely asymptomatic populations potential hot spots for transmission that necessitate frequent diagnostic testing. In this study, we employed large-scale GIS (geographic information systems)-enabled building-level monitoring system associated with on-campus residences 7,614 individuals. Sixty-eight automated samplers were deployed monitor 239 buildings focus on residential buildings. Time-weighted composite samples collected daily basis analyzed same day. Sample processing was streamlined significantly through automation, reducing turnaround time 20-fold exceeding scale similar programs 10- 100-fold, thereby overcoming one biggest bottlenecks in surveillance. An notification developed alert residents positive sample their residence encourage uptake campus-provided testing at no charge. This system, integrated rest "Return Learn" program University California (UC) San Diego-led diagnosis nearly 85% all cases campus. rates increased 1.9 13× following notifications. Our study shows robust, efficient greatly reduce risk college campuses other high-risk environments reopen. IMPORTANCE epidemiology can be particularly valuable where high-resolution spatial sampling well-controlled context not only provide insight into what affects community well how those inferences extended broader city/county context. present successfully implemented large enabling detection averting outbreaks. The highly reporting enabled dramatic reduction 5 h (sample result time) 96 samples. Furthermore, miniaturization pipeline brought down cost ($13/sample). Taken together, these results show such ameliorate long-term communities they look

Language: Английский

Citations

131
Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs DOI Open Access
Sasha Harris-Lovett, Kara L. Nelson, Paloma I. Beamer

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(9), P. 4455 - 4455

Published: April 22, 2021

Wastewater surveillance for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging approach to help identify risk of a disease (COVID-19) outbreak. This tool can contribute public health at both community (wastewater treatment system) and institutional (e.g., colleges, prisons, nursing homes) scales. paper explores successes, challenges, lessons learned from initial wastewater efforts colleges university systems inform future research, development implementation. We present experiences 25 college in United States that monitored campus SARS-CoV-2 during fall 2020 academic period. describe broad range approaches, findings, resources, impacts these efforts. These institutions size, social political geographies, include private institutions. Our analysis suggests monitoring requires consideration local information needs, sewage infrastructure, resources sampling analysis, dynamics, approaches interpretation communication results, follow-up actions. Most reported learning process experimentation, evaluation, adaptation was key progress. ongoing collaboration among diverse stakeholders including decision-makers, researchers, faculty, facilities staff, students, members.

Language: Английский

Citations

129
SARS-CoV-2 Wastewater Surveillance for Public Health Action DOI Creative Commons

Jill S. McClary-Gutierrez,

Mia Mattioli,

Perrine Marcenac

et al.

Emerging infectious diseases, Journal Year: 2021, Volume and Issue: 27(9), P. 1 - 8

Published: Aug. 19, 2021

Abstract Wastewater surveillance for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has garnered extensive public attention during the disease pandemic as a proposed complement to existing systems. Over past year, methods detection and quantification of SARS-CoV-2 viral RNA in untreated sewage have advanced, concentrations wastewater been shown correlate with trends reported cases. Despite promise surveillance, these measurements translate into useful health tools, bridging communication knowledge gaps between researchers responders is needed. We describe key uses, barriers, applicability supporting decisions actions, including establishing ethics consideration monitoring. Although assess community infections not new idea, might be initiating event make this emerging tool sustainable nationwide system, provided that barriers are addressed.

Language: Английский

Citations

119
Enumerating asymptomatic COVID-19 cases and estimating SARS-CoV-2 fecal shedding rates via wastewater-based epidemiology DOI Open Access

Bradley W. Schmitz,

Gabriel K. Innes,

Sarah M. Prasek

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 801, P. 149794 - 149794

Published: Aug. 20, 2021

Language: Английский

Citations

108
Correlation between SARS-CoV-2 RNA concentration in wastewater and COVID-19 cases in community: A systematic review and meta-analysis DOI Creative Commons
Xuan Li, Shuxin Zhang, Samendra P. Sherchan

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 441, P. 129848 - 129848

Published: Aug. 28, 2022

Language: Английский

Citations

89
Wastewater analysis can be a powerful public health tool—if it’s done sensibly DOI Creative Commons
Hannah Safford, Karen Shapiro, Heather N. Bischel

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(6)

Published: Feb. 3, 2022

The coronavirus disease 2019 (COVID-19) pandemic sparked an explosion of interest in wastewater-based epidemiology (WBE; also known as wastewater monitoring or surveillance). Much has been said, the scientific literature and popular press alike, about public health value tracking severe acute respiratory syndrome 2 (SARS-CoV-2) wastewater. Emergence spread omicron variant recently pushed WBE for COVID-19 management back into headlines. Unfortunately, coverage potential is rarely balanced by a practical discussion limitations tradeoffs, especially when it comes to issues beyond technical challenges encountered lab. Sometimes makes sense way monitor outbreaks other threats, sometimes constraints argue spending scarce resources elsewhere. We grapple with such frequently while managing program Healthy Davis Together (HDT), multi-pronged pandemic-response initiative Davis, CA. Since launching September 2020, grown include in-house analysis collected on weekly, triweekly, daily basis from 70 sites distributed across City University California, (UC Davis) campus sewer systems influent their treatment plants. are glad that our data informing local mitigation efforts. Results UC dorm outflows supporting safe return students campus; results neighborhoods broader city areas helping officials understand spatial changes trends react accordingly. At same time, running campaign requires significant investments money, labor, expertise. Given much information gleaned not directly actionable, and/or duplicates sources, prudent consider these worthwhile. … [↵][1]1To whom correspondence may be addressed. Email: hbischel{at}ucdavis.edu. [1]: #xref-corresp-1-1

Language: Английский

Citations

86