Exposure to 6-PPD quinone enhances lipid accumulation through activating metabolic sensors of SBP-1 and MDT-15 in Caenorhabditis elegans DOI
Yuxing Wang, Xin Hua, Dayong Wang

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 333, P. 121937 - 121937

Published: June 10, 2023

Language: Английский

Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity DOI
Xin Hua, Dayong Wang

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132265 - 132265

Published: Aug. 15, 2023

Language: Английский

Citations

82
Environmental Occurrence and Toxicity of 6PPD Quinone, an Emerging Tire Rubber-Derived Chemical: A Review DOI
Khaled Zoroufchi Benis, Ali Behnami, Shahab Minaei

et al.

Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 10(10), P. 815 - 823

Published: Sept. 1, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a chemical added to tires prevent their oxidative degradation. 6PPD highly reactive with ozone and oxygen, leading the formation of transformation products such as quinone (6PPDQ) on tire surfaces and, subsequently, in road wear particles. 6PPDQ toxicant that has been found roadway runoff receiving water systems. Its presence municipal stormwater led acute mortality coho salmon during migration urban creeks reproduce, generating global interest studying its occurrence toxicity environment. This review aims provide critical overview current state knowledge 6PPDQ, assisting researchers policymakers understanding potential impacts this emerging environment human health. As there are many unanswered questions surrounding further research needed. highlights importance including regulations for 6PPD, well all synthetic chemicals concern.

Language: Английский

Citations

57
Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB/c mice DOI
Wenmiao He, Aihua Gu, Dayong Wang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 894, P. 164842 - 164842

Published: June 17, 2023

Language: Английский

Citations

55
Where the rubber meets the road: Emerging environmental impacts of tire wear particles and their chemical cocktails DOI Creative Commons
Paul M. Mayer, Kelly D. Moran, Ezra Miller

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 171153 - 171153

Published: March 7, 2024

About 3 billion new tires are produced each year and about 800 million become waste annually. Global dependence upon from natural rubber petroleum-based compounds represents a persistent complex environmental problem with only partial often-times, ineffective solutions. Tire emissions may be in the form of whole tires, tire particles, chemical compounds, which is transported through various atmospheric, terrestrial, aquatic routes built environments. Production use generates multiple heavy metals, plastics, PAH's, other that can toxic alone or as cocktails. Used require storage space, energy intensive to recycle, generally have few post-wear uses not also potential sources pollutants (e.g., crumb rubber, pavements, burning). particles emitted during major component microplastics urban runoff source unique highly potent substances. Thus, represent ubiquitous pollutant requires comprehensive examination develop effective management remediation. We approach issue pollution holistically by examining life cycle across production, emissions, recycling, disposal. In this paper, we synthesize recent research data human health risks associated use, disposal discuss gaps our knowledge fate transport, well toxicology leachates. examine remediation approaches for addressing exposure tires. consider three levels: their state, particulates, mixture Finally, information understanding outline key questions improve ability manage remediate pollution.

Language: Английский

Citations

50
Widespread occurrence of two typical N, N’-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage DOI
Shiming Song, Yanxia Gao,

Shuai Feng

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133835 - 133835

Published: Feb. 19, 2024

Language: Английский

Citations

37
Occurrence of p-phenylenediamine antioxidants in human urine DOI
Weili Mao, Hangbiao Jin,

Ruyue Guo

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 170045 - 170045

Published: Jan. 12, 2024

Language: Английский

Citations

31
Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans DOI

Xin Hua,

Dayong Wang

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170760 - 170760

Published: Feb. 6, 2024

Language: Английский

Citations

28
Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics DOI
Wenmiao He,

Chao Jie,

Aihua Gu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171220 - 171220

Published: Feb. 25, 2024

Language: Английский

Citations

26
Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans DOI
Yuxing Wang, Geyu Liang, Jie Chao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172306 - 172306

Published: April 7, 2024

Language: Английский

Citations

25
Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans DOI

Zhengying Liu,

Qian Bian, Dayong Wang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134356 - 134356

Published: April 19, 2024

Language: Английский

Citations

25