Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(43), P. 19165 - 19177
Published: Oct. 18, 2024
Scholars
have
long
been
interested
in
the
association
between
arsenic
(As)
exposure
and
neurological
disorders;
however,
existing
systematic
epidemiological
investigations
are
insufficient
lack
inclusion
of
diagnostic
or
predictive
biological
markers.
This
study
sought
to
evaluate
As
cognitive
impairment
identify
potential
biomarkers
by
developing
models.
Here,
we
found
that
logarithm
(Ln)-transformed
urinary
concentrations
were
negatively
linearly
related
mini-mental
state
examination
(MMSE)
score
exposure-response
curves.
Subsequently,
identified
a
unique
plasma
neurometabolite
profile
subjects
exposed
compared
with
reference
group.
Further
analyses
showed
tryptophan,
tyrosine,
dopamine,
epinephrine,
homovanillic
acid
all
significantly
associated
both
MMSE
scores.
Notably,
scores
was
partly
mediated
epinephrine.
Importantly,
an
unprecedented
prediction
model
utilizing
neurotransmitters
established
assess
risk
due
exposure.
A
91.1%
consistency
rate
predicted
actual
probabilities.
Additionally,
machine
learning
models
also
produced
highly
accurate
predictions.
Overall,
this
revealed
dose-dependent
decline
As-exposed
adults
accompanied
disturbance
signature
neurotransmitter
metabolites,
offering
new
insights.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Dec. 6, 2023
Gut-liver-brain
axis
is
a
three-way
highway
of
information
interaction
system
among
the
gastrointestinal
tract,
liver,
and
nervous
systems.
In
past
few
decades,
breakthrough
progress
has
been
made
in
gut
liver
brain
axis,
mainly
through
understanding
its
formation
mechanism
increasing
treatment
strategies.
this
review,
we
discuss
various
complex
networks
including
barrier
permeability,
hormones,
microbial
metabolites,
vagus
nerve,
neurotransmitters,
immunity,
toxic
β-amyloid
(Aβ)
metabolism,
epigenetic
regulation
gut-liver-brain
axis.
Some
therapies
containing
antibiotics,
probiotics,
prebiotics,
synbiotics,
fecal
microbiota
transplantation
(FMT),
polyphenols,
low
FODMAP
diet
nanotechnology
application
regulate
Besides,
some
special
treatments
targeting
gut-liver
include
farnesoid
X
receptor
(FXR)
agonists,
takeda
G
protein-coupled
5
(TGR5)
glucagon-like
peptide-1
(GLP-1)
antagonists
fibroblast
growth
factor
19
(FGF19)
analogs.
Targeting
gut-brain
embraces
cognitive
behavioral
therapy
(CBT),
antidepressants
tryptophan
metabolism-related
therapies.
liver-brain
contains
Aβ
future,
better
interactions
will
promote
development
novel
preventative
strategies
discovery
precise
therapeutic
targets
multiple
diseases.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
278, P. 116360 - 116360
Published: April 27, 2024
Methylmercury
(MeHg)
is
a
neurotoxin
associated
with
foetal
neurodevelopmental
and
adult
cognitive
deficits.
Neurons
are
highly
dependent
on
the
tricarboxylic
acid
cycle
oxidative
phosphorylation
to
produce
ATP
meet
their
high
energy
demands.
Therefore,
mitochondrial
quality
control
(MQC)
critical
for
neuronal
homeostasis.
While
existing
studies
have
generated
wealth
of
data
toxicity
MeHg,
complex
cascades
molecular
pathways
governing
network
remain
be
elucidated.
Here,
0.6,
1.2
2.4
mg/kg
body
weight
MeHg
were
administered
intragastrically
pregnant
Sprague
Dawley
rats
model
maternal
exposure.
The
results
in
vivo
study
revealed
that
MeHg-treated
tended
perform
more
directionless
repetitive
strategies
Morris
Water
Maze
fewer
target-orientation
than
offspring.
Moreover,
pathological
injury
synaptic
observed
hippocampus.
Transmission
electron
microscopy
(TEM)
demonstrated
autophagosomes
encapsulated
damaged
mitochondria,
while
showing
typical
fission
phenotype,
which
was
supported
by
activation
PINK1-dependent
key
regulators
mitophagy.
there
upregulation
DRP1
FIS1.
Additionally,
compensation
promoted
biogenesis,
as
evidenced
PGC1-α-NRF1-TFAM
signalling
pathway.
Notably,
SIRT3/AMPK
activated
expression
activity
p-AMPK,
p-LKB1
SIRT3
consistently
coordinated.
Collectively,
these
findings
provide
new
insights
into
potential
mechanisms
regulating
MeHg-induced
deficits
through
MQC
coordination.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 243 - 243
Published: Feb. 7, 2025
The
microbiota-gut-brain
axis
is
a
complex
bidirectional
communication
system
that
involves
multiple
interactions
between
intestinal
functions
and
the
emotional
cognitive
centers
of
brain.
These
are
mediated
by
molecules
(metabolites)
produced
in
both
areas,
which
considered
mediators.
To
shed
light
on
this
mechanism,
still
largely
unknown,
reliable
characterization
mediators
essential.
Here,
we
review
most
studied
metabolites
axis,
metabolic
pathways
they
involved,
their
functions.
This
focuses
mainly
use
mass
spectrometry
for
determination,
reporting
latest
analytical
methods,
limitations,
future
perspectives.
strategy
qualitative-quantitative
must
be
order
to
elucidate
molecular
mechanisms
underlying
influence
above-mentioned
stress
resilience
or
vulnerability.
Toxicology,
Journal Year:
2023,
Volume and Issue:
494, P. 153580 - 153580
Published: June 15, 2023
Food
represents
the
major
risk
factor
for
exposure
to
mercury
in
most
human
populations.
Therefore,
passage
through
gastrointestinal
tract
plays
a
fundamental
role
its
entry
into
organism.
Despite
intense
research
carried
out
on
toxicity
of
Hg,
effects
at
intestinal
level
have
received
increased
attention
only
recently.
In
this
review
we
first
provide
critical
appraisal
recent
advances
toxic
Hg
epithelium.
Next,
dietary
strategies
aimed
diminish
bioavailability
or
modulate
epithelial
and
microbiota
responses
will
be
revised.
components
additives,
including
probiotics,
considered.
Finally,
limitations
current
approaches
tackle
problem
future
lines
discussed.
Reviews on Environmental Health,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 18, 2023
During
the
last
decade,
there
has
been
an
increase
in
exposure
to
heavy
metals
that
can
affect
human
health
and
environment,
especially
mercury
(Hg)
cadmium
(Cd).
These
exposures
pollute
rivers
or
oceans,
then
contaminating
marine
organisms.
Humans
as
consumer
of
this
food
chain
cycle
be
a
place
for
bioaccumulation
Hg
Cd,
people
living
coastal
areas,
including
pregnant
women.
Exposure
Cd
have
high
risk
triggering
blood
vessel
disorders,
penetrating
blood-brain
barrier
(BBB)
placental
barrier,
one
which
preeclampsia.
Several
immunological
biomarkers
such
some
cytokines
associated
with
are
also
involved
pathophysiology
preeclampsia,
implantation
process
endothelial
dysfunction
Therefore,
countries
incidence
preeclampsia
should
aware
environmental
factors,
metal
pollution
Cd.
