Long-term ambient ozone exposure and incident cardiovascular diseases: National cohort evidence in China

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134158 - 134158

Published: March 30, 2024

Language: Английский

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Assessing the effectiveness of long short-term memory and artificial neural network in predicting daily ozone concentrations in Liaocheng City

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 25, 2025

Ozone pollution affects food production, human health, and the lives of individuals. Due to rapid industrialization urbanization, Liaocheng has experienced increasing ozone concentration over several years. Therefore, become a major environmental problem in City. Long short-term memory (LSTM) artificial neural network (ANN) models are established predict concentrations City from 2014 2023. The results show general improvement accuracy LSTM model compared ANN model. Compared ANN, an increase determination coefficient (R2), value 0.6779 0.6939, decrease root mean square error (RMSE) 27.9895 μg/m3 27.2140 absolute (MAE) 21.6919 20.8825 μg/m3. prediction is superior terms R, RMSE, MAE. In summary, promising technique for predicting concentrations. Moreover, by leveraging historical data enables accurate predictions future on global scale. This will open up new avenues controlling mitigating pollution.

Language: Английский

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Long-term exposure to fine particulate matter constituents and cognitive impairment among older adults: An 18-year Chinese nationwide cohort study

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133785 - 133785

Published: Feb. 13, 2024

Language: Английский

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Indoor environment and brain health across the life course: A systematical review

Building and Environment, Journal Year: 2024, Volume and Issue: unknown, P. 112156 - 112156

Published: Oct. 1, 2024

Language: Английский

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Mediation of depressive symptoms in the association between blood urea nitrogen to creatinine ratio and cognition among middle-aged and elderly adults: evidence from a national longitudinal cohort study

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 19, 2024

Abstract Background The relationships between BUNCr (blood urea nitrogen and creatinine ratio) cognitive function, as well depressive symptoms, remain unclear. We aim to investigate the association cognition, identify mechanisms underlying these relationships. Methods utilized data from China Health Retirement Longitudinal Study (CHARLS) 2015 2020. Cognitive function was assessed using Telephone Interview of Status (TICS) scale, while symptoms were 10-item Center for Epidemiologic Studies Depression Scale (CES-D-10). employed multivariate linear regression models examine symptoms. Additionally, causal mediation analysis conducted potential effects cognition. Results observed a negative ( coefficient : -0.192; 95% confidence interval [ CI ]: -0.326 ∼ -0.059) positive relationship 0.145; 0.006 0.285). In addition, revealed that (proportion mediated: 7.0%) significantly mediated Conclusion Our study has unveiled is inversely associated with positively linked Moreover, we found These findings provide new evidence insights prevention management dementia.

Language: Английский

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Impact of climate and environmental change on the menopause

Maturitas, Journal Year: 2023, Volume and Issue: 178, P. 107825 - 107825

Published: Aug. 25, 2023

The huge impact of climate change on humankind is multidimensional, and includes direct indirect challenges to the physical, psychological socio-cultural wellbeing. Women may be more vulnerable climate-sensitive diseases, but little attention has been paid specific needs associated with menopause transition. increase in average extreme temperatures modulate manifestation vasomotor symptoms; particular, environmental temperature seasonality affect hot flushes night sweats. However, research needed define climate-related factors among determinants influencing individual experience menopause. In addition, increased exposure pollution toxins also have a role modulation ovarian aging mechanisms, possibly timing Finally, both air transition are unfavorable modifications cardio-metabolic, bone cognitive health, account should taken these evaluation woman's health vulnerabilities. Overall, evidence reported this narrative review supports need for strategies aimed at reducing burden menopausal women. Healthcare providers promote behavioral measures that reduce anthropogenic same time beneficial several domains physical From perspective, represents golden moment implement virtuous behaviors will benefit women's longevity planet.

Language: Английский

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Neighborhood environment and cognitive functioning in middle-aged and older population: A mediating role of physical activity

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 264, P. 114521 - 114521

Published: Jan. 13, 2025

Evidence on the impact of complex neighborhood environment, including air pollution, greenness, and socioeconomic deprivation (nSED) cognitive health in older adults remains scarce. Both cognition environment are associated with physical activity, but little is known about potential mediating role activity this association. Cross-sectional data Czech arm HAPIEE cohort study examined 4,178 participants (55.6% women) aged 45-69 years. Global score was constructed from memory, verbal fluency, concentration domains. The exposures, assigned to participant's addresses, include 4-year (2000-2003) average concentrations PM2.5, greenness index calculated tree crown canopy cover estimation (2000), census-based nSED characteristics. Physical other covariates were assessed by a questionnaire. Structural equation modelling used estimate standardized β coefficients for relationships between performance. After controlling range covariates, global function inversely PM2.5 (β = -0.087; 95%CI: 0.122 -0.052) -0.147; 0.182 -0.115), positively 0.036; 0.001 0.069). We identified weak statistically significant associations exposures score. Total mediation proportions ranged 3.9% 6.5% respectively. individuals; partially mediated activity.

Language: Английский

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Closing the gap in dementia research by community-based cohort studies in the Chinese population

The Lancet Regional Health - Western Pacific, Journal Year: 2025, Volume and Issue: 55, P. 101465 - 101465

Published: Jan. 21, 2025

Language: Английский

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Temporal distribution of environmental pollutants in high-occupancy buildings transitional spaces and exposure risk assessment for different flow paths

Building and Environment, Journal Year: 2025, Volume and Issue: unknown, P. 112840 - 112840

Published: March 1, 2025

Language: Английский

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Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109501 - 109501

Published: April 25, 2025

Ozone (O3) and nanoplastics (NPs) are pervasive environmental pollutants that frequently co-occur in our heavily industrialized era. While it has been documented exposure to O3 or NPs individually neurotoxic effects, studies investigating their combined impact the hazardous mechanisms resulting from co-exposure limited. In this study, we established a mouse model polystyrene nanoparticles (PS-NPs) O3, focusing on prefrontal cortex (PFC), brain region crucial for cognition emotion. We examined effects of PS-NPs behavioral changes related learning, memory, anxiety, employing transcriptome sequencing alongside molecular histopathological methods. Our findings indicate disrupts integrity blood-brain barrier, reducing Claudin 5 expression leading increased accumulation PFC. Transcriptome demonstrated involvement p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway oxidative stress pathological observed Through immunohistochemical immunofluorescence analysis, enhanced microglial activation, which correlates with production inflammatory factors. Additionally, western blot co-labeling analyses revealed elevated levels GSDMD-N, caspase-1, IL-1β, IL-18 proteins, associated neuronal pyroptosis. Finally, confirmed activation MAPK neurons is involved co-exposure-induced Meanwhile, N-Acetylcysteine (NAC), common antioxidant, can alleviate neuroinflammation pyroptosis PFC, rescued cognitive deficits anxiety-like behaviors co-exposed mice. study illustrates aggravate damage barrier elevate thereby increasing occurrence may mediate through pathway, ultimately contributing neurobehavioral toxicity.

Language: Английский

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