Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses DOI Open Access
Alan Ducatman, Lida Chatzi

Medical Research Archives, Journal Year: 2023, Volume and Issue: 11(12)

Published: Jan. 1, 2023

Background: This perspective concerning hepatoxicity of per- and polyfluoroalkyl substances (PFAS) aims to provide a current understanding the damage reasonable clinician responses needs concerned patients affected communities. Methods: Search strategy included PFAS following: human liver toxicity/disease; relevant biomarkers including transaminases, lipids, uric acid; predictive equations (for disease), imaging modalities, histologic findings. Experimental data outcomes disrupted hepatic metabolic pathways was also reviewed. Recommended clinical approaches communities sought in both National Library Medicine organizational websites. Results: Several reliably cause adverse changes biomarkers, with strong consistency between experimental data. Adverse population include cholesterol LDL cholesterol, acid. biomarker triad suggests that mechanisms are or resemble associated steatotic disease, which is found across species following exposure. Human studies sparse mostly support inference toxicant resembles pathway can lead from steatosis more serious stages disease due metabolism fatty acids. Advice clinicians reviewed various agencies nonprofits organizations committee US Academies Sciences, Engineering, Medicine, nonprofit/university collaboration REACH. Discussion: Converging lines evidence indict as (and trans-species) hepatotoxins continuum nature injury. Increases abnormal transaminases sparser biopsy findings clinically important contributing public health problem. It still challenging decide many definitively is/are most Many use remain virtually unstudied, research emergency. Simple concerns heavily contaminated communities, within capabilities offices,

Language: Английский

Public Health Risks of PFAS-Related Immunotoxicity Are Real DOI Creative Commons
Abigail P. Bline, Jamie C. DeWitt, Carol F. Kwiatkowski

et al.

Current Environmental Health Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 118 - 127

Published: March 25, 2024

Abstract Purpose of Review The discovery per- and polyfluoroalkyl substances (PFAS) in the environment humans worldwide has ignited scientific research, government inquiry, public concern over numerous adverse health effects associated with PFAS exposure. In this review, we discuss use immunotoxicity data regulatory clinical decision-making contexts question whether recent efforts adequately account for decision-making. Recent Findings Government academic reviews confirm strongest human evidence is reduced antibody production response to vaccinations, particularly tetanus diphtheria. However, events, such as economic analysis supporting proposed national primary drinking water regulations monitoring recommendations, indicate a failure incorporate these into decisions. Summary To be more protective health, recommend using all relevant inform current future PFAS-related chemical risk assessment regulation. Biological measures immune system effects, levels vaccination, should used valid informative markers outcomes risks Routine toxicity testing expanded include evaluations adult developing organisms. addition, recommendations PFAS-exposed individuals communities revisited strengthened provide guidance on incorporating other actions that can taken protect against outcomes.

Language: Английский

Citations

22
Non-Invasive Matrices for the Human Biomonitoring of PFAS: An Updated Review of the Scientific Literature DOI Creative Commons
Martí Nadal, José L. Domingo

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 134 - 134

Published: Feb. 12, 2025

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in consumer industrial products due to their unique physicochemical properties. However, persistence bioaccumulative potential pose significant environmental human health risks. This review focuses on the use of non-invasive matrices-urine, hair, nails-for biomonitoring PFAS, highlighting key findings from scientific studies. While urine offers a practical option, its limited sensitivity for long-chain PFAS requires further analytical advances. Hair nails have demonstrated biomonitoring, with higher detection frequencies concentrations certain compared urine. The variability levels across studies reflects differences population characteristics, exposure sources, geographic regions. emphasizes need standardized methods, expanded studies, complementary matrices enhance accuracy reliability assessment.

Language: Английский

Citations

2
PFAS in Nigeria: Identifying data gaps that hinder assessments of ecotoxicological and human health impacts DOI Creative Commons

Kenneth N Kikanme,

Nicole M Dennis,

Ochuko Felix Orikpete

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29922 - e29922

Published: April 21, 2024

This review examines the extensive use and environmental consequences of Per-and Polyfluoroalkyl Substances (PFAS) on a global scale, specifically emphasizing their potential impact in Nigeria.Recognized for resistance to water oil, PFAS are under increased scrutiny persistent nature possible ecotoxicological risks.Here, we consolidate existing knowledge ecological human health effects Nigeria, focusing neurological risks they pose immune system health.We seek balance advantages with hazards, thereby enhancing understanding management Nigeria advocating more effective policy interventions creation safer alternatives.The concludes several recommendations: strengthening regulatory frameworks, intensifying research into impacts PFAS, developing new methodologies longitudinal studies, fostering collaborative efforts management, promoting public awareness education support sustainable practices healthier communities Nigeria.

Language: Английский

Citations

15
Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: Multiple pathways for wildlife and human exposure DOI
Christopher C. Witt, Chauncey R. Gadek, Jean‐Luc E. Cartron

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 249, P. 118229 - 118229

Published: Feb. 5, 2024

Language: Английский

Citations

13
Per-and polyfluoroalkyl (PFAS) eternal pollutants: Sources, environmental impacts and treatment processes DOI

Hela Rekik,

Hamed Arab, Loick Pichon

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 358, P. 142044 - 142044

Published: April 21, 2024

Language: Английский

Citations

11
Intersecting planetary health: Exploring the impacts of environmental stressors on wildlife and human health DOI Creative Commons
Fu Chen,

Feifei Jiang,

Jing Ma

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116848 - 116848

Published: Aug. 7, 2024

This comprehensive review articulates critical insights into the nexus of environmental stressors and their health impacts across diverse species, underscoring significant findings that reveal profound effects on both wildlife human systems. Central to our examination is role pollutants, climate variables, pathogens in contributing complex disease dynamics physiological disruptions, with particular emphasis immune endocrine functions. research brings light emerging evidence severe implications pressures a variety taxa, including predatory mammals, raptorial birds, seabirds, fish, humans, which are pivotal as indicators broader ecosystem stability. We delve nuanced interplay between degradation zoonotic diseases, highlighting novel intersections pose risks biodiversity populations. The critically evaluates current methodologies advances understanding morphological, histopathological, biochemical responses these organisms stressors. discuss for conservation strategies, advocating more integrated approach incorporates zoonoses pollution control. synthesis not only contributes academic discourse but also aims influence policy by aligning Global Goals Sustainable Development. It underscores urgent need sustainable interactions humans environments, preserving ensuring global security. By presenting detailed analysis interdependencies biological health, this highlights gaps provides foundation future studies aimed at mitigating pressing issues. Our study it proposes integrative actionable strategies address challenges intersection change public marking crucial step forward planetary science.

Language: Английский

Citations

5
Addressing the Persistence of Per- and Poly-fluoroalkyl substances (PFAS): Current Challenges and Potential Solutions DOI Creative Commons
Emeka J. Itumoh,

Shailja Data,

Jack L.‐Y. Chen

et al.

RSC Sustainability, Journal Year: 2024, Volume and Issue: 2(11), P. 3183 - 3201

Published: Jan. 1, 2024

The combined stability, mobility, and bioaccumulation of per- poly-fluoroalkyl substances (PFAS) has prompted a global environmental crisis.

Language: Английский

Citations

5
Two for the Price of One: Deriving Per- and Polyfluoroalkyl Substances (PFAS) Fillet and Whole-Body Conversion Equations in Fish DOI
Eric Levanduski, Wayne Richter, Jesse C. Becker

et al.

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(6), P. 511 - 517

Published: March 6, 2024

Per- and polyfluoroalkyl substances (PFAS) pose risks to both human ecological health. Fish consumption advisories are typically based on fillet concentrations, whereas environmental risk assessment for biota depends whole-body fish concentrations. Reliable equations conversion between concentrations would allow a single analysis of function assessment. However, do not exist multiple species, previous estimates small sample sizes. Here, we assess relationships in 21 species provide perfluorooctanesulfonic acid (PFOS), perfluorodecanoic (PFDA), perfluoroundecanoic (PFUnA), perfluorododecanoic (PFDoA), four the most common PFAS detected from New York State. We analyzed 429 15 water bodies as separate remainder portions then used weights these synthesize concentration. Using linear models combining all ratio ranged 1.77 1.91 across chemicals. Total factors 1.86 0.52 fillet. These values showed consistency among chemicals, but were lower than those species-specific models, suggesting latter ideal

Language: Английский

Citations

4
Investigating the Molecular Interactions of Two Long-Chain PFASs with Human Serum Albumin: Insights from Multispectral Analysis and Computational Methods DOI
Yao Wu, Erdeng Du, Xichen Wang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 751, P. 151356 - 151356

Published: Feb. 1, 2025

Language: Английский

Citations

0
A High Efficiency Method for the Extraction and Quantitative Analysis of 45 PFAS in Whole Fish DOI
Sarah Balgooyen,

Mary Celine Scott,

Brett R. Blackwell

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

This study describes and validates a new method for extracting perfluoroalkyl polyfluoroalkyl substances (PFAS) from whole-body fish tissue, demonstrates that freeze-dry preservation of tissue conserves bioaccumulative PFAS, details demonstration on Lake Michigan fish. While filets are more commonly analyzed their significance to human health, whole useful determine ecological impacts, but published methods such as EPA 1633 do not produce reliable results this challenging matrix. Here we show lipid removal technology produces clean extracts without the need solid-phase extraction or evaporative concentration, which often lead loss some PFAS. achieves an accuracy 96 ± 9% detection 45 PFAS while also offering benefits simple procedure, reduced processing time, decreased waste generation compared multistep cleanup concentration methods. A test freeze-drying demonstrated compounds detected in Great Lakes were retained, volatile including sulfonamide precursors ethanols lost. To demonstrate field performance, entire was applied whole-fish composites Michigan. Results these samples reveal driven by collection location, distribution dictated species.

Language: Английский

Citations

0