Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142802 - 142802
Published: July 10, 2024
Language: Английский
Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142802 - 142802
Published: July 10, 2024
Language: Английский
Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 209, P. 106344 - 106344
Published: Feb. 21, 2025
Language: Английский
Citations
1Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110190 - 110190
Published: Feb. 1, 2025
Language: Английский
Citations
1Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(10), P. 4581 - 4593
Published: Feb. 29, 2024
An emerging environmental contaminant, bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), can bioaccumulate in the liver and affect hepatic lipid metabolism. However, in-depth mechanism has yet to be comprehensively explored. In this study, we utilized transgenic zebrafish Tg (Apo14: GFP) image interference of TBPH on development metabolism at early stage. Using integrated lipidomic transcriptomic analyses profile remodeling effect, uncovered potential effects lipophagy-related signaling pathways larvae. Decreased contents accompanied by enhanced lipophagy were confirmed measurements Oil Red O staining transmission electron microscopy tissues. Particularly, regulatory role foxo1 factor was validated via its transcriptional inhibitor. Double immunofluorescence with biochemical analysis indicated that mitochondrial fatty acid oxidation induced reversed To summarize, our study reveals, for first time, essential foxo1-mediated TBPH-induced metabolic disorders hepatoxicity, providing new insights disease studies ecological health risk assessment TBPH.
Language: Английский
Citations
8Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 479, P. 135704 - 135704
Published: Aug. 30, 2024
Language: Английский
Citations
5Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133252 - 133252
Published: Dec. 14, 2023
Language: Английский
Citations
13Toxicology, Journal Year: 2024, Volume and Issue: 503, P. 153759 - 153759
Published: Feb. 16, 2024
Language: Английский
Citations
2Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 288, P. 117418 - 117418
Published: Nov. 28, 2024
Language: Английский
Citations
2Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117061 - 117061
Published: Sept. 19, 2024
Language: Английский
Citations
1Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(6), P. 114703 - 114703
Published: Nov. 6, 2024
Language: Английский
Citations
1Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136886 - 136886
Published: Dec. 14, 2024
Language: Английский
Citations
0