Both
NPs
and
PCBs
are
emerging
contaminants
widely
distributed
in
the
environment,
it
is
worth
exploring
whether
combination
of
two
causes
serious
pollution
harm.
Therefore,
we
studied
effects
PS-NPs
PCB-44
alone
together
after
96
h
21
d
exposure
to
C.
pyrenoidosa.
The
results
showed
that
affected
cell
cycle
pyrenoidosa
inhibited
its
normal
growth.
Physiologically,
increased
relative
conductivity
algal
solution,
decreased
surface
hydrophobicity
cells,
reduced
synthesis
chlorophyll
a
b.
Biochemically,
induced
oxidative
stress
with
significant
changes
enzymatic
activities
SOD
CAT
MDA
content.
Moreover,
expression
photosynthesis-related
genes
(psbA,
rbcL,
rbcS)
all
responded,
negatively
affecting
photosynthesis.
In
particular,
toxic
were
observed
single
co-exposure
PCB-44,
similar
trends
acute
chronic
experiments.
Taken
together,
caused
negative
on
growth
physiological
biochemistry
These
provide
scientific
information
further
explore
aquatic
organisms
ecosystems.
Environmental Health Perspectives,
Journal Year:
2024,
Volume and Issue:
132(2)
Published: Feb. 1, 2024
Micro-
and
nanoplastics
(MNPs)
homosalate
(HMS)
are
ubiquitous
emerging
environmental
contaminants
detected
in
human
samples.
Despite
the
well-established
endocrine-disrupting
effects
(EDEs)
of
HMS,
interaction
between
MNPs
HMS
its
impact
on
HMS-induced
EDEs
remain
unclear.
Aquatic Toxicology,
Journal Year:
2025,
Volume and Issue:
279, P. 107255 - 107255
Published: Jan. 24, 2025
Ecotoxicological
risk
and
the
mode
of
action
human
drugs
on
non-target
marine
animals
remain
unclear,
keeping
a
gap
knowledge
risks
related
to
ecosystem
disruption
chemical
contamination
food
chains.
Understanding
these
impacts
is
critical
developing
proper
waste
management
practices
regulatory
frameworks
prevent
long-term
environmental
health
problems.
This
study
investigates
Gemfibrozil,
Metformin,
Ramipril,
Venlafaxine,
individually
combined
Mytilus
galloprovincialis
over
30
days
assesses
persistent
effects
post-recovery
using
RNA-seq
16S
rRNA
microbiota
profiling.
All
pharmaceuticals
caused
few
changes
in
while
gene
expression
analyses
highlighted
drug-specific
alterations.
Gemfibrozil
exposure
led
alterations
lipid
fatty
acid
metabolism,
suggesting
similar
that
observed
target
species.
Metformin
significantly
impacted
mussels'
energy
with
disruptions
specific
genes
pathways
potentially
glucose
uptake
insulin
signaling.
was
also
treatment
leading
most
significant
predicted
functional
profiles
microbiota,
it
may
influence
microbiota's
potential
interact
host
metabolism.
Ramipril
resulted
up-regulation
stress
response
cell
cycle
regulation
Venlafaxine
induced
serotonin
synapse
pathways,
indicating
similarities
mechanisms
Mixture
four
severely
mussel
physiology,
including
impairment
oxidative
phosphorylation
compensatory
activation
several
involved
Despite
recovery
after
depuration,
metabolism
suggests
from
pharmaceutical
exposure.
Notably,
mTOR1
signaling
all
treatments
underscores
its
key
role
coordinating
bivalve
responses.
The
Transcriptomic
Hazard
Index
(THI)
calculated
for
each
indicates
major/severe
hazards
decreased
slight/moderate
depuration.
