Identification of 2, 4-di-tert-butylphenol from Microcystis lysate after bloom control and its potential risks to aquatic ecosystems DOI
Binliang Wang, Xuan Lan,

Danni Kong

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136153 - 136153

Published: Oct. 11, 2024

Language: Английский

Exposure to environmental levels of 2,4-di-tert-butylphenol affects digestive glands and induces inflammation in Asian Clam (Corbicula fluminea) DOI
J. Z. Zhang, Xuefang Liang, Huihui Chen

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 915, P. 170054 - 170054

Published: Jan. 18, 2024

Language: Английский

Citations

10
Environmental occurrence and ecotoxicological risks of plastic leachates in aquatic and terrestrial environments DOI

Kehinde Caleb Omidoyin,

Eun Hea Jho

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176728 - 176728

Published: Oct. 9, 2024

Language: Английский

Citations

9
Effects of the plastic additive 2,4-di-tert-butylphenol on intestinal microbiota of zebrafish DOI
Yongmeng Yang,

Chen Yan,

Aifeng Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133987 - 133987

Published: March 8, 2024

Language: Английский

Citations

7
Long-term exposure to 2,4-di-tert-butylphenol impairs zebrafish fecundity and affects offspring development DOI

Huina Gao,

Yuchen Wang, Xuefang Liang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138108 - 138108

Published: March 1, 2025

Language: Английский

Citations

0
Size- and Duration-Dependent Toxicity of Heavy Vehicle Tire Wear Particles in Zebrafish DOI
Qianqian Song,

Qingxuan Meng,

Xinrui Meng

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138299 - 138299

Published: April 1, 2025

Language: Английский

Citations

0
Oxidative stress status and antioxidative responses in neonate versus adult Daphnia magna exposed to polystyrene leachate DOI Creative Commons
Maranda Esterhuizen‐Londt,

Michela Monticelli,

Sang‐Ah Lee

et al.

Toxicology and Environmental Health Sciences, Journal Year: 2024, Volume and Issue: 16(2), P. 171 - 179

Published: March 25, 2024

Abstract Objective Plastic pollution, particularly polystyrene, significantly threatens aquatic ecosystems worldwide. Furthermore, plastic leachates have been documented to be detrimental some organisms; however, understanding the toxicity mechanism remains limited. This study aimed investigate ecotoxicological effects of polystyrene leachate on neonate and adult Daphnia magna , a keystone species in freshwater ecosystems. Methods The were studied by employing novel technique separating daphnids from microplastic fragments via dialysis tubing, which was prepared 24 72 h before organism exposure. Acute assessed as mobility, oxidative stress (reactive oxygen species), antioxidative enzyme responses (superoxide dismutase catalase), well biotransformation glutathione S-transferase’s activity. Results Under experimental conditions, mobility status unaffected, irrespective organisms’ age or leaching time. In adults exposed for h, antioxidant defense activities elevated, contributing cellular homeostasis maintenance. However, catalase activity reduced neonates prolonged pre-leached treatment, thus making them less capable retaining when toxicant mixtures. Conclusion highlights vulnerability D. underscores need continued research pollution Findings this investigation contribute ecological consequences can inform mitigation strategies policy decisions preserve health integrity

Language: Английский

Citations

2
Developmental effects of fenpropathrin on zebrafish (Danio rerio) embryo-larvae: Toxic endpoints and potential mechanism DOI
Junguo Ma,

Chunyu Diao,

Yidan Zhang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 208, P. 106262 - 106262

Published: Dec. 17, 2024

Language: Английский

Citations

1
Impact of 2,4-di-tert-butylphenol on pancreatic lipase activity in emulsions: Multispectral, molecular docking, and in vitro digestion analysis DOI

Guan Weiyan,

Juan Cheng,

David Julian McClements

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 142730 - 142730

Published: Dec. 1, 2024

Language: Английский

Citations

1
Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio) DOI Creative Commons
Jiaqi Xie,

Yuxiang Yin,

Bixiao Lin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116937 - 116937

Published: Sept. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Language: Английский

Citations

0
Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish DOI Creative Commons
Yumin Luo,

Han Run,

Zhengyu Ren

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: 6(1), P. 374 - 387

Published: Oct. 8, 2024

Abstract Flavors are widely utilized in the food and oral pharmaceutical industry, particularly products for children, to enhance palatability promote ingestion willingness. The complex compositions of flavors potentially induce severer toxicity especially children. In this study, zebrafish embryos applied screening flavor its compounds by immersing solutions followed assessment morphology larvae. Geraniol is identified as prominent toxic compound considered highly embryo. further toxicology geraniol demonstrates concentration‐dependent developmental obvious reduction body eye lengths, well increased prevalence tail deformities, pericardial edema, spine deformation. Zebrafish larvae treated with exhibit liver area exocrine pancreas length, increase yolk sac area, elevation triglycerides total cholesterol, which indicate inhibited nutrient utilization. Transcriptome analysis reveals that under treatment, 248 differentially expressed genes (DEGs) downregulated, whereas 23 DEGs upregulated, 110 related metabolic process. Biological processes lipid metabolism, carbohydrate protein hydrolysis, transmembrane transport, including their involved functional genes, all downregulated. These findings reveal affecting utilization‐related organs development biological processes. This study establishes an efficient model identifying during developing stages, thereby elucidating potential safety risks exposure providing a comprehensive understanding mechanism.

Language: Английский

Citations

0