Effect of chronic low-dose microcystin-LR exposure on jejunum apoptosis via RAF/ERK signaling pathway in mouse DOI
Sharon R. Long, Cong Wen, Wen Zeng

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 88(7), P. 291 - 300

Published: Dec. 12, 2024

Microcystin-LR (MC-LR), a class of cyclic heptapeptide compounds synthesized by cyanobacterial species, presents significant risk to ecological systems and public health. Exposure MC-LR was found induce damage various organs. One the target organ affected is gastrointestinal tract (GIT). However, majority studies regarding GIT focused on colorectal toxicity, with little attention paid small intestinal toxic injuries, in particular jejunum. Thus, aim this study investigate effects attributed exposure apoptosis underlying mechanisms utilizing mouse jejunum injury model following chronic low-dose treatment. A total 40 C57BL/6 male mice were randomly divided into 4 groups each group receiving drinking water containing 0, 1, 60, or 120 µg/L for duration 12 months. Results indicated that induced pathological alterations jejunal tissue as evidenced abnormal villous serration, crypt disorganization, lymphocyte infiltration. TUNEL assays demonstrated increase apoptotic cell count 60 groups. The treatment exhibited elevated mRNA expression Bax accompanied reduction Bcl-2. protein levels cleaved caspase-3 markedly p-RAF p-ERK significantly increased Data suggest RAF/ERK signaling pathway may be involved MC-LR- apoptosis.

Language: Английский

Ferroptosis induced by environmental pollutants and its health implications DOI Creative Commons
Fu‐Han Gong, Liyuan Liu,

Xuesheng Wang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Language: Английский

Citations

1
Algae blooms with resistance in fresh water: Potential interplay between Microcystis and antibiotic resistance genes DOI
Wenhui Ji,

Jingkai Ma,

Zhipeng Zheng

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 940, P. 173528 - 173528

Published: May 25, 2024

Language: Английский

Citations

5
Melamine-induced adrenal structural and functional alterations and the contribution of morin to the adrenal repair in Wistar rats DOI

Alshaymaa M. Abdelmenem,

Ezat A. Mersal, Ahmed A. Morsi

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102826 - 102826

Published: March 1, 2025

Language: Английский

Citations

0
Ultrastructural, molecular and haemato-immunological changes: Multifaceted toxicological effects of microcystin-LR in rohu, Labeo rohita DOI

Snatashree Mohanty,

Anirban Paul,

Sagar Banerjee

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 358, P. 142097 - 142097

Published: April 22, 2024

Language: Английский

Citations

3
Metabolomics reveals the lipid metabolism disorder in Pelophylax nigromaculatus exposed to environmentally relevant levels of microcystin-LR DOI
Yinan Zhang,

Wenhui Sun,

Feng Wang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 358, P. 124458 - 124458

Published: June 26, 2024

Language: Английский

Citations

3
Newly isolated strains of potentially microcystin-producing cyanobacteria in potable water: case study of Mawoni village, South Africa DOI Creative Commons
Mulalo I. Mutoti, Jabulani R. Gumbo,

Adivhaho Khwathisi

et al.

Frontiers in Environmental Science, Journal Year: 2024, Volume and Issue: 12

Published: July 25, 2024

Toxic cyanobacterial species occur in aquatic ecosystems when favourable environmental conditions prevail. These bacteria can produce natural hepatotoxic metabolites called microcystins that affect the quality of water. Human exposure to results from ingesting contaminated drinking water and therefore producing these toxins should be monitored waters. The present study aimed trace identify strains potentially To achieve this objective, advanced digital flow cytometry polymerized chain reaction were used for detection identification samples collected storage containers Mawoni village. Full-length 16S rRNA genes cultured cyanobacteria amplified sequenced using primers. Three novel Chroococcus sp. (m64187e-7881, m64187e-2143, m64187e-0930) two Microcystis aeruginosa (m64187e-6729 m64187e-1069) detected identified samples. presence could indicate potential occurrence water, which therefore, human health risk due such cyanotoxins.

Language: Английский

Citations

0
A Histopathological Study on the Deleterious Effect of Chronic Levothyroxine Sodium Administration on the Gastric Mucosa of Adult Male Albino Rats DOI

Rabab M. Amer,

Shaimaa M. Motawea,

Walaa S. Elseady

et al.

Journal of Microscopy and Ultrastructure, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Language: Английский

Citations

0
Adverse outcome pathway of Alzheimer’s Disease-like changes resulting from autophagy flux blockade after MC-LR exposure DOI
Yuhan Ma, Dihui Xu,

Yibin Gan

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 364, P. 125322 - 125322

Published: Nov. 15, 2024

Language: Английский

Citations

0
Effect of chronic low-dose microcystin-LR exposure on jejunum apoptosis via RAF/ERK signaling pathway in mouse DOI
Sharon R. Long, Cong Wen, Wen Zeng

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 88(7), P. 291 - 300

Published: Dec. 12, 2024

Microcystin-LR (MC-LR), a class of cyclic heptapeptide compounds synthesized by cyanobacterial species, presents significant risk to ecological systems and public health. Exposure MC-LR was found induce damage various organs. One the target organ affected is gastrointestinal tract (GIT). However, majority studies regarding GIT focused on colorectal toxicity, with little attention paid small intestinal toxic injuries, in particular jejunum. Thus, aim this study investigate effects attributed exposure apoptosis underlying mechanisms utilizing mouse jejunum injury model following chronic low-dose treatment. A total 40 C57BL/6 male mice were randomly divided into 4 groups each group receiving drinking water containing 0, 1, 60, or 120 µg/L for duration 12 months. Results indicated that induced pathological alterations jejunal tissue as evidenced abnormal villous serration, crypt disorganization, lymphocyte infiltration. TUNEL assays demonstrated increase apoptotic cell count 60 groups. The treatment exhibited elevated mRNA expression Bax accompanied reduction Bcl-2. protein levels cleaved caspase-3 markedly p-RAF p-ERK significantly increased Data suggest RAF/ERK signaling pathway may be involved MC-LR- apoptosis.

Language: Английский

Citations

0