Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108848 - 108848
Published: Jan. 1, 2025
Language: Английский
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4186 - 4202
Published: April 30, 2024
As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.
Language: Английский
Citations
10
Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 320 - 320
Published: April 28, 2024
Microplastics (MPs) are now ubiquitous environmental contaminants that lead to unavoidable human exposure; they have received increasing attention in recent years and become an emerging area of research. The greatest concern is the negative impacts MPs on marine, fresh-water, terrestrial ecosystems, as well health, extent World Health Organization (WHO) calls for increased research standardized methods assess exposure MPs. Many countries international organizations implementing or proposing legislation this regard. This review aims summarize current state legislation, indoor outdoor contamination, potential health risk due airborne MPs, considering occupational also becoming a growing concern. Even though regarding has continuously last twenty years, effects been scarcely investigated, toxicity studies still limited not directly comparable, lack field.
Language: Английский
Citations
9
Environment International, Journal Year: 2025, Volume and Issue: 195, P. 109266 - 109266
Published: Jan. 1, 2025
Polystyrene nanoplastics (PS-NPs) are omnipresent in the air and can be inhaled by humans. However, their long-term adverse implications toxicological mechanisms for human respiratory health unclear. Therefore, this study aims to provide new insights into pulmonary toxicity of PS-NPs using mice organoid models. After subacute subchronic inhalation PS-NPs, showed pronounced lung injury characterized rate changes, altered hematology, histological evidence tissue damage oxidative stress. Similarly, repeated exposure also restricted growth cause damage. Notably, through BisqueRNA analysis a single-cell dataset canonical markers verification, it was found that induced emergence accumulation transitional cells, suggesting impaired alveolar epithelial repair processes. Sequencing analyses revealed dynamic alterations non-coding RNA (ncRNA) profiles, including circRNAs lncRNAs, response exposure. Moreover, temporal profiling highlighted distinct sets ncRNAs as early progression-associated biomarkers PS-NP-induced injury. These correlated with aberrant implicating roles disrupted cellular differen tiation mechanisms. Overall, observed multifaceted responses system, emphasizing critical involvement mediating PS-NP-induce which crucial elucidating pathophysiology nanoplastic-induced developing targeted therapeutic strategies.
Language: Английский
Citations
1
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117828 - 117828
Published: Feb. 1, 2025
Microplastics pollution has raised a considerable awareness due to their extensive distribution in the environment. It potential side effects on human health. can enter respiratory system, then deposit lung, destroying structure of bronchus and alveoli, causing pulmonary inflammation, mucus production, airway hyperresponsiveness, leading aggravation asthma. Nevertheless, underlying mechanism remains elusive. There are several cytokines involved inflammatory response Heat shock protein 90α(HSP90α) is one involving inflammation which member HSPs family. The aim this study explore by microplastics influence secretion HSP90α progression Initially, we found that were destroyed epithelial barrier, resulting inherent dysfunction HSP90α. Then, proved activate PI3K-Akt-mTOR pathway prompting cells secrete proliferation smooth muscle cells(ASMCs), narrowing hypersensitivity. 1G6-D7 monoclonal antibody HSP90, reverse infiltration, hyperresponsiveness(AHR). Overall, these finding suggested elicited via signaling stimulated ASMCs. Hence, present unveils novel responsible for microplastic-induced hyperreactivity, establishing basis further research risk evaluations microplastics.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7074 - 7074
Published: June 27, 2024
Microplastics (MPs) pervade the environment, infiltrating food sources and human bodies, raising concerns about their impact on health. This review is focused three key questions: (i) What type of polymers are humans most exposed to? (ii) prevalent shapes MPs found in samples? (iii) Are data influenced by detection limit size particles? Through a systematic literature analysis, we have explored polymer types samples. The provide evidence that polyester commonly detected humans, followed polyamide, polyurethane, polypropylene, polyacrylate. Fibres emerge as predominant shape across all categories, suggesting potential environmental contamination from textile industry. Studies drinking water reported small particles, contrast to larger research, particular seafood. Discrepancies methodologies different reports were identified, which could some discussed trends. study highlights need for more comprehensive research interactions between biological systems effects toxicity, together with standardised analytical accurately assess levels exposure. Understanding these dynamics essential formulating effective strategies mitigate health implications MP pollution.
Language: Английский
Citations
7
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136145 - 136145
Published: Oct. 11, 2024
Language: Английский
Citations
6
Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108740 - 108740
Published: May 11, 2024
The intensification of microplastics (MPs) pollution has emerged as a formidable environmental challenge, with profound global implications. pervasive presence MPs across multitude mediums, such the atmosphere, soil, and oceans, extends to commonplace items, culminating in widespread human ingestion accumulation via channels like food, water, air. In domestic realm, kitchens have become significant epicenters for pollution. A plethora kitchen utensils, encompassing coated non-stick pans, plastic cutting boards, disposable are known release substantial quantities particles everyday use, which can then be ingested alongside food. This paper conducts thorough examination contemporary research addressing from utensils during usage focuses on health risks associated ingestion, well myriad factors influencing utensils. Leveraging insights derived this analysis, proposes series strategic recommendations measures targeted at mitigating production settings. These initiatives designed not solely diminish but also enhance public awareness regarding pressing concern. By adopting more informed practices kitchens, we significantly contribute reduction burden pollution, thus safeguarding both ecological system.
Language: Английский
Citations
5
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 944, P. 173799 - 173799
Published: June 11, 2024
Language: Английский
Citations
5
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175361 - 175361
Published: Aug. 6, 2024
Language: Английский
Citations
5
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175614 - 175614
Published: Aug. 18, 2024
Language: Английский
Citations
5