Effect of Fluoride on Gut Microbiota: A Systematic Review DOI Creative Commons
Momina Yasin, Fatemeh Vida Zohoori, Elizabeth Adjoa Kumah

et al.

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Fluoride can prevent dental caries by inhibiting demineralization and promoting remineralization of teeth while affecting the physiology oral microbiota, thus cellular enzymes. However, effect systemic fluoride on gut microbiota is unknown. To explore impacts composition abundance associated functions such as gene metabolic regulation. A systematic database search was conducted MEDLINE, Web Science, Scopus, PubMed, CINAHL, Embase to find articles studies reporting effects microbiota. Forty-nine were included (n = 42 in animals, 4 humans, 3 vitro studies) after screening for title, abstract, full text using Covidence check against eligibility criteria. Data extracted study quality assessed Mixed Method Appraisal Tool 2 reviewers independently. Two human fluorosis 1 patients with breast cancer (intestinal fluorine-18 fluorodeoxyglucose uptake) showed significant differences microbial composition, increased relative Acidobacteria Proteobacteria, decreased Firmicutes Bacteroidetes. An ex vivo feces indicated that ≤ mg L-1 NaF might boost "health-associated" taxa, but concentrations (≥ 10 NaF) could increase ratio some unhealthy microbes 24 hours. The animal examined high doses water diet (50-1200 long-term (1-6 months) short-term (6 hours 7 days) exposure, all showing a disturbance Bacteroidota ratio. In potentially may be detrimental microbiome, whereas had positive effects. Similarly, ≥ 50 unsafe, 25 harmless PROSPERO registration No. CRD42022347357.

Language: Английский

F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells DOI
Yue Zhang, Tingting Li,

Xueman Ding

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137111 - 137111

Published: Jan. 5, 2025

Language: Английский

Citations

2
F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis DOI Creative Commons
Penghui Nie,

Yuzhi Lan,

Tao You

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 277, P. 116399 - 116399

Published: April 26, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as pollutants, can cause palpable environmental health impacts around the world, endocrine disruptors, disrupt homeostasis increase risk of diseases. Chlorinated ether sulfonate (F-53B), a substitute for PFAS, was determined to have potential toxicity. Puberty is stage when sexual organs develop hormones change dramatically, abnormal uterine development lesions lead infertility. This study designed explore impact F-53B on during puberty. Four-week-old female SD rats were exposed 0.125 6.25 mg/L The results showed that interfered with growth sex hormone levels bound oestrogen-related receptors, which affected their function, contributed accumulation reactive oxygen species, promoted cell apoptosis inhibited proliferation, ultimately causing dysplasia.

Language: Английский

Citations

6
Contribution of gut microbiota to hepatic steatosis following F-53B exposure from the perspective of glucose and fatty acid metabolism DOI
Xueyan Gu,

Huihui Yang,

Wu Liu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136104 - 136104

Published: Oct. 9, 2024

Language: Английский

Citations

3
Adolescent F-53B exposure induces ovarian toxicity in rats: Autophagy-apoptosis interplay DOI

Yuzhi Lan,

Penghui Nie, Qiang Yu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175609 - 175609

Published: Aug. 18, 2024

Language: Английский

Citations

1
Lactiplantibacillus plantarum P101-fermented Luffa cylindrica Juice Alleviate F-53B-Induced Liver Steatosis in Mice via the Gut-liver axis DOI
X. R. Wang,

Tiancheng Zhao,

Jinfeng Zhang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105442 - 105442

Published: Nov. 8, 2024

Language: Английский

Citations

0
Effect of Fluoride on Gut Microbiota: A Systematic Review DOI Creative Commons
Momina Yasin, Fatemeh Vida Zohoori, Elizabeth Adjoa Kumah

et al.

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Fluoride can prevent dental caries by inhibiting demineralization and promoting remineralization of teeth while affecting the physiology oral microbiota, thus cellular enzymes. However, effect systemic fluoride on gut microbiota is unknown. To explore impacts composition abundance associated functions such as gene metabolic regulation. A systematic database search was conducted MEDLINE, Web Science, Scopus, PubMed, CINAHL, Embase to find articles studies reporting effects microbiota. Forty-nine were included (n = 42 in animals, 4 humans, 3 vitro studies) after screening for title, abstract, full text using Covidence check against eligibility criteria. Data extracted study quality assessed Mixed Method Appraisal Tool 2 reviewers independently. Two human fluorosis 1 patients with breast cancer (intestinal fluorine-18 fluorodeoxyglucose uptake) showed significant differences microbial composition, increased relative Acidobacteria Proteobacteria, decreased Firmicutes Bacteroidetes. An ex vivo feces indicated that ≤ mg L-1 NaF might boost "health-associated" taxa, but concentrations (≥ 10 NaF) could increase ratio some unhealthy microbes 24 hours. The animal examined high doses water diet (50-1200 long-term (1-6 months) short-term (6 hours 7 days) exposure, all showing a disturbance Bacteroidota ratio. In potentially may be detrimental microbiome, whereas had positive effects. Similarly, ≥ 50 unsafe, 25 harmless PROSPERO registration No. CRD42022347357.

Language: Английский

Citations

0