Se Alleviated Pb-Caused Neurotoxicity in Chickens: SPS2-GPx1-GSH-IL-2/IL-17-NO Pathway, Selenoprotein Suppression, Oxidative Stress, and Inflammatory Injury

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 370 - 370

Published: March 18, 2024

Lead (Pb), a heavy metal environmental pollutant, poses threat to the health of humans and birds. Inflammation is one most common pathological phenomena in case illness poisoning. However, underlying mechanisms inflammation remain unclear. The cerebellum thalamus are important parts nervous system. To date, there have been no reports Pb inducing animal cerebellums or thalami. Selenium (Se) can relieve Therefore, we aimed explore mechanism by which Se alleviates toxicity thalami chickens establishing chicken or/and treatment model. Our results demonstrated that exposure caused inflammatory damage thalami, evidenced characteristics inflammation, decrease anti-inflammatory factors (interleukin (IL)-2 interferon-γ (INF-γ)), increase pro-inflammatory (IL-4, IL-6, IL-12β, IL-17, nitric oxide (NO)). Moreover, found IL-2/IL-17–NO pathway took part Pb-caused injury. above findings were reversed supplementation dietary Se, meaning relieved via pathway. In addition, an up-regulated oxidative index malondialdehyde (MDA) two down-regulated antioxidant indices (glutathione (GSH) total capacity (TAC)) recorded after received stimulation, indicating excess oxidant/antioxidant imbalance stress, stress mediated GSH–IL-2 axis. Interestingly, inhibited four glutathione peroxidase (GPx) family members (GPx1, GPx2, GPx3, GPx4), three deiodinase (Dio) (Dio1, Dio2, Dio3), fifteen other selenoproteins (selenophosphate synthetase 2 (SPS2), selenoprotein (Sel)H, SelI, SelK, SelM, SelO, SelP1, SelPb, SelS, SelT, SelU, (Sep)n1, Sepw1, Sepx1, Sep15), suggesting reduced resulted involving SPS2–GPx1–GSH supplementation, as expected, changes mentioned above, improved mitigated chickens. For first time, discovered SPS2–GPx1–GSH–IL-2/IL-17–NO involved complex conclusion, this study Pb-induced This offers novel insights into pollutant-caused poisoning provides theoretical basis for detoxification effect against toxic pollutants.

Language: Английский

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Molecular mechanism of apoptosis induced by 4-tBP in common carp (Cyprinus carpio L.) head kidneys was explored from various angles: Hippo pathway, miR-203a, oxidative stress, ER stress, and mitochondrial pathway

Aquaculture, Journal Year: 2024, Volume and Issue: 589, P. 740981 - 740981

Published: April 21, 2024

Language: Английский

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The investigation on stress mechanisms of Sepia esculenta larvae in the context of global warming and ocean acidification

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 36, P. 102120 - 102120

Published: May 8, 2024

Sepia esculenta is a tasty and nutritious cephalopod. But the trend toward global warming accelerating with massive emissions of greenhouse gases. An increase in seawater temperature decrease pH are great challenge for artificial breeding culture S. esculenta. In this study, we investigated contingency mechanism larvae under both high low conditions by transcriptome analysis. A total 1235 DEGs were identified. functional enrichment analysis results suggest that led to malignant proliferation exceptional cells larvae. comprehensive KEGG signaling pathway protein-protein interaction network (PPI) identified sixteen key genes conditions. The three highest quantities interactions or involved more pathways as hub affecting normal physiological processes effects ocean acidification on metabolism immunity preliminarily provide necessary help captive face climate change.

Language: Английский

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The impact of dietary supplementation of polysaccharide derived from Polygonatum sibiricum on growth, antioxidant capacity, meat quality, digestive physiology, and gut microbiota in broiler chickens

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103675 - 103675

Published: March 22, 2024

Polygonatum sibiricum polysaccharide (PSP) has demonstrated diverse medicinal properties, extensively researched for human applications. Nonetheless, there is a lack of studies investigating the potential advantages PSP in poultry farming. The present study investigated impact incorporating into broiler diets on their growth performance, meat quality, blood metabolites, antioxidative status, and ileal histomorphology. Two hundred forty-one-day-old male Ross-308 chicks (44.98 ± 0.79 g) were randomly assigned to 3 experimental groups, with 8 replicates 10 birds each. fed supplemented at 0, 400, 800 mg/kg (control, PSP400, PSP800, respectively). results revealed linear (P > 0.05) improvement body weight gain, European production efficiency index, feed conversion ratio during grower (22-35 d) overall periods (1-35 d). pH levels ingluvies, ileum, cecum exhibited reduction PSP800 group d 21 35, respectively. Villus height crypt depth increased PSP400 groups compared control group. decreased hydrogen peroxide (H

Language: Английский

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Silybin prevented avermectin-induced cardiotoxicity in carp by modulating oxidative stress, inflammation, endoplasmic reticulum stress, mitochondrial apoptosis, and autophagy

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 150, P. 109624 - 109624

Published: May 11, 2024

Language: Английский

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Golgi apparatus regulated pyroptosis through the miR-32-5p/Golga7/NLRP3 axis in chicken splenic lymphocytes exposure to ammonia

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 124923 - 124923

Published: Sept. 1, 2024

Language: Английский

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Micro/nano plastics in the urinary system: Pathways, mechanisms, and health risks

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109109 - 109109

Published: Nov. 1, 2024

Micro/Nano plastics (MNPs) pollutants are widespread in the environment, raising significant concerns about their biosafety. Emerging studies indicate that urinary system is a primary accumulation site for MNPs, leading to severe tissue and functional damage. This review aims summarize recent research on potential hazards MNPs may pose system, highlighting mechanisms of toxicity current state knowledge. Studies have shown enter human body through drinking water, food chain, inhalation, skin contact. They penetrate bloodstream via digestive, respiratory, systems, subsequently dispersing various organs, including system. The might induce cellular oxidative stress, inflammation, apoptosis, autophagy, "intestine-kidney axis", other possible toxic mechanisms. These processes could disrupt kidney metabolic functions promote fibrosis, thereby potentially increasing risk diseases. Despite ongoing research, understanding MNPs' impact remains limited. Therefore, this provides comprehensive overview highlights key challenges, outlines future directions. It offers theoretical basis development effective protective measures policies.

Language: Английский

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Investigation of the vasodilatory, tocolytic and spasmolytic effects of rutin on Wistar rats tissues

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100172 - 100172

Published: Feb. 1, 2025

Language: Английский

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Preparation, characterization and in vitro evaluation of anticancer and antioxidant effects of luteolin-loaded nanocapsules

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106754 - 106754

Published: Feb. 1, 2025

Language: Английский

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Thermodynamics, Kinetics, and Mechanism of Luteolin Adsorption on Nickel-Doped Amino-Modified Silica

Russian Journal of General Chemistry, Journal Year: 2025, Volume and Issue: 95(1), P. 239 - 252

Published: Jan. 1, 2025

Language: Английский

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