Microplastics from face masks: Unraveling combined toxicity with environmental hazards and their impacts on food safety DOI

Luyu Pei,

Lina Sheng, Yongli Ye

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(6)

Published: Nov. 1, 2024

Microplastics (MPs) refer to tiny plastic particles, typically smaller than 5 mm in size. Due increased mask usage during COVID-19, improper disposal has led masks entering the environment and releasing MPs into surroundings. can absorb environmental hazards transfer them humans animals via food chain, yet their impacts on safety human health are largely neglected. This review summarizes release process of from face masks, influencing factors, safety. Highlights given prevalence combined toxicities with other hazards. Control strategies also explored. The is affected by factors like pH, UV light, temperature, ionic strength, weathering. chemical active surface large area, act as vectors for heavy metals, toxins, pesticides, antibiotics antibiotic resistance genes, foodborne pathogens through different mechanisms, such electrostatic interaction, precipitation, bioaccumulation. After being adsorbed MPs, toxicity these hazards, oxidative stress, cell apoptosis, disruption metabolic energy levels, be magnified. However, there a lack comprehensive research both well corresponding control strategies. Future should prioritize understanding interaction toxicity, integrating detection degradation methods

Language: Английский

Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review DOI Open Access
X. Zhang, Zhenxing Yin,

Songbai Xiang

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2807 - 2807

Published: Oct. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Language: Английский

Citations

9
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota DOI Creative Commons
Jingwen Guo, Tao You, Xiaoyan Feng

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Microplastics (MPs) and Di-(2-ethylhexyl) phthalate (DEHP) as emerging contaminants, have caused increasing concern due to their co-exposure risks toxicities humans. Lactic acid bacteria been demonstrated play a significant role in the mitigation of organismal damage. Probiotic intervention is widely recognized safe healthy therapeutic strategy for targeting organic This study explored effectiveness underlining mechanism an excellent probiotic property Lactiplantibacillus plantarum P101 (L. P101) combined hepatotoxicity MPs DEHP. In this study, mice were exposed DEHP via free drinking water, followed by with L. P101. Results showed that severe oxidative stress inflammation liver intestines, which was reversed after intervention. Moreover, reshaped structure gut microbiota alleviated damage exposure. Together, we found effectively mitigated toxic effects on system DEHP, offering promising reducing toxicity these substances.

Language: Английский

Citations

0
Impact of 4-tert-Butylphenol on Inflammation and Glycogen Metabolism in Cyprinus carpio L via the miR-363/PKCδ Axis DOI Creative Commons
Jiawen Cui,

Xinchi Shang,

Yuhao Liu

et al.

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
Quercetin Alleviates Pyroptosis and Necroptosis Triggered on by DEHP Exposure in Bursa of Fabricius in Chicken by the ROS/MAPK/NF-κB Pathway DOI
Chenxi Huang, Xiaodan Wang, Wenwen Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Bis(2-ethylhexyl) phthalate (DEHP) is an endocrine disruptor that may cause damage to several species. Quercetin (Que), a common flavonoid, has anti-inflammation, antioxidation, and immune regulation properties. In this study, we identified DEHP-exposed or Que-antagonist groups in chicken MSB-1 cells explore whether Que can mitigate DEHP-caused bursa of Fabricius pyroptosis necroptosis. The findings demonstrated reduced the expression necroptosis pyroptosis, inhibited mitogen-activated protein kinase (MAPK)/NF-κB pathway, mitigated oxidative stress caused by DEHP. addition reactive oxygen species activator (Sanguinarin) raised extent stress, NF-κB (nuclear factor-kappa-B activator1, act1) activated MAPK/NF-κB pathway compared + DEHP group. conclusion, counteract DEHP-induced programmed necrosis. This work adds toxicological consequences on avian further theoretical justification for Que's treatment organic toxic damage.

Language: Английский

Citations

0
Polystyrene Nanoplastics Induce Lipid Metabolism Disorder by Activating the PERK-ATF4 Signaling Pathway in Mice DOI

Ziteng Yu,

Xingpei Fan,

Xinyi Zhao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34524 - 34537

Published: June 26, 2024

In recent years, the study of microplastics (MPs) and nanoplastics (NPs) their effects on human health has gained significant attention. The impacts NPs lipid metabolism specific mechanisms involved remain poorly understood. To address this, we utilized high-throughput sequencing molecular biology techniques to investigate how endoplasmic reticulum (ER) stress might affect hepatic in presence polystyrene (PS-NPs). Our findings suggest that PS-NPs activate PERK-ATF4 signaling pathway, which turn upregulates expression genes related synthesis via ATF4-PPARγ/SREBP-1 pathway. This activation leads an abnormal accumulation droplets liver. 4-PBA, a known ER inhibitor, was found mitigate PS-NPs-induced disorder. These results demonstrate hepatotoxic clarify induced by PS-NPs.

Language: Английский

Citations

2
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS DOI
Yuexian Xu, Guoxiang Li,

Defeng Ge

et al.

Urolithiasis, Journal Year: 2024, Volume and Issue: 52(1)

Published: Aug. 13, 2024

Language: Английский

Citations

2
Environmental and Sublethal Concentrations of Polystyrene Nanoplastics Induced Antioxidant System, Transcriptomic Responses, and Disturbed Gut Microbiota in Oyster Magallana Hongkongensis DOI
Bin Wang, Muhammad Junaid, Muhammad Imran

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(24), P. 13581 - 13592

Published: June 4, 2024

Nanoplastics (NPs) are emerging contaminants having persistent nature, diverse ecological impacts, and potential food safety risks. Here, we examined the ecotoxicity of 80 nm polystyrene nanoplastics (PS-NPs) at environmentally relevant concentrations (ERCs, 10 100 μg/L), sublethal (SLCs, 500 2500 μg/L) in Magallana hongkongensis. Results showed that SLCs significantly (p < 0.05) increased superoxide dismutase (SOD), catalase (CAT), alkaline phosphatase (AKP) activities altered tnfα, cat, gst, sod, se-gpx genetic expressions. Further, PS-NP exposure both levels reduced beneficial bacteria potentially pathogenic gut. In transcriptomic analysis, 5118 4180 differentially expressed genes (DEGs) were identified ERCs, while 5665 4817 DEGs found SLCs, respectively. Upregulated enriched lysosomes, ABC transporters, apoptosis pathways, downregulated ribosomal pathways. Overall, ERCs gut microbiota responses, addition, also impacted antioxidant immune systems.

Language: Английский

Citations

2
In vitro and in silico analyses reveal the toxicity of metolachlor to grass carp hepatocytes and the antagonism of melatonin DOI
Qianru Chi, Xia Yu,

Dongliu Luo

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 202, P. 105930 - 105930

Published: April 27, 2024

Language: Английский

Citations

1
TGF-β/SMAD Pathway Mediates Cadmium Poisoning-Induced Chicken Liver Fibrosis and Epithelial-Mesenchymal Transition DOI
Jinyang Zhang,

Yiming Sun,

Miao Yu

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Language: Английский

Citations

1
The size-dependence and reversibility of polystyrene nanoplastics-induced hepatic pyroptosis in mice through TXNIP/NLRP3/GSDMD pathway DOI

Yanyang Lu,

Weizhen Hua,

Lu Lu

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(4)

Published: July 1, 2024

As emerging environmental contaminants, nanoplastics (NPs) are progressively accumulating in terrestrial and aquatic ecosystems worldwide, posing a potential threat to human health. The liver is considered as one of the primary organs targeted by NPs accumulation living organisms. However, there remains large knowledge gap concerning NPs-induced hepatotoxicity. In this study, we examined impact chronic exposure environmentally relevant doses polystyrene (PS) on hepatic pyroptosis mice. results demonstrated that both particle sizes PS-NPs (100 nm 500 nm) significantly triggered mouse liver, evidenced upregulation GSDMD-N protein levels; moreover, pyroptotic effect induced 100 was more pronounced compared PS-NPs. Mechanistically, resulted an TXNIP expression, thereby activating NLRP3 inflammasome subsequently inducing inflammatory responses pyroptosis. Notably, following termination subsequent recovery period 50 days, PS-NPs-mediated inflammation via TXNIP/NLRP3 pathway were effectively ameliorated, even returning levels close baseline. Collectively, our findings provide novel evidence for size-dependence reversibility through TXNIP/NLRP3/GSDMD vivo.

Language: Английский

Citations

1