Overcoming cancer chemotherapy resistance by the induction of ferroptosis

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 66, P. 100916 - 100916

Published: Dec. 29, 2022

Language: Английский

---

Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 12(1), P. 92 - 106

Published: Aug. 14, 2021

Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to the obstacles of anticancer delivery. However, clinical outcomes and translation are restricted by several drawbacks, such low loading, premature leakage carrier-related toxicity. Recently, pure nano-assemblies (PDNAs), fabricated self-assembly or co-assembly molecules, attracted considerable attention. Their facile reproducible preparation technique helps remove bottleneck nanomedicines including quality control, scale-up production translation. Acting both carriers cargos, carrier-free PDNAs an ultra-high even 100% loading. In addition, combination therapies based on could possibly address most intractable problems in cancer treatment, tumor metastasis resistance. present review, latest development for treatment is overviewed. First, classified according composition assembly mechanisms discussed. Furthermore, co-delivery summarized, with special focus improvement therapeutic outcomes. Finally, future prospects challenges efficient therapy spotlighted.

Language: Английский

---

Tumor Selective Metabolic Reprogramming as a Prospective PD‐L1 Depression Strategy to Reactivate Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(41)

Published: Aug. 26, 2022

Currently, the role of lysosome, endoplasmic reticulum, or dictyosome in transcription and translation programmed cell death ligand 1 (PD-L1) is well revealed, but function mitochondria PD-L1 expression tumors still not fully researched, making it hard to offer a novel regulation strategy. In this research, newly revealed that oxidative phosphorylation (OXPHOS) depression can be used as an effective down-regulation method. To ideal high-effective tumor mitochondria-targeted OXPHOS nanosystem, IR-LND prepared by conjugating heptamethine cyanine dye IR-68 with mitochondrial complexes I II agent lonidamine (LND), which then further self-assembled albumin (Alb) form IR-LND@Alb nanoparticles. By doing this, selectively effectively depressed As expected, anti-tumor efficacy such strategy superior conventional anti-PD-L1 monoclonal antibodies. Interestingly, also served promising photodynamic therapy (PDT) drug self-oxygen self-PD-L1 capacity. All all, tumor-selective metabolic reprogramming platform reactivate immunotherapy sensitize for PDT effect, would open new window cancer patients.

Language: Английский

---

Extracellular vesicles and particles impact the systemic landscape of cancer

The EMBO Journal, Journal Year: 2022, Volume and Issue: 41(18)

Published: Sept. 2, 2022

Language: Английский

---

Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5236 - 5236

Published: Aug. 16, 2022

Throughout the United States, cancer remains second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that specific have few consequences. Curcumin a polyphenol derivative found turmeric plant (Curcuma longa L.), provides chemopreventive, antitumor, chemo-, radio-sensitizing properties. In this paper, we summarize new nano-based formulations polyphenolic curcumin because growing interest its application against cancers tumors. According recent studies, use nanoparticles can overcome hydrophobic nature curcumin, as well improving stability cellular bioavailability vitro vivo. Several strategies nanocurcumin production been developed, each with own set advantages unique features. Because majority curcumin-based nanoformulation evidence still conceptual stage, numerous issues impeding provision possible therapeutic option. To support science, further work necessary develop viable anti-cancer adjuvant. review, cover various nanoformulations implications uses cancer, current state clinical studies patents. We address knowledge gaps future research orientations required feasible treatment candidate.

Language: Английский

---

Cancer metastasis: Molecular mechanisms and clinical perspectives

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 250, P. 108522 - 108522

Published: Sept. 1, 2023

Language: Английский

---

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 9, 2023

Abstract The biological complexity of cancer represents a tremendous clinical challenge, resulting in the frequent failure current treatment protocols. In rapidly evolving scenario growing tumor, anticancer treatments impose drastic perturbation not only to cells but also tumor microenvironment, killing portion and inducing massive stress response survivors. Consequently, can act as double-edged sword by temporary while laying ground for therapy resistance subsequent disease progression. Cancer cell dormancy (or quiescence) is central theme evolution, being tightly linked tumor’s ability survive cytotoxic challenges, metastasize, resist immune-mediated attack. Accordingly, quiescent (QCCs) have been detected virtually all stages development. recent years, an increasing number studies focused on characterization quiescent/therapy resistant cells, unveiling QCCs core transcriptional programs, metabolic plasticity, mechanisms immune escape. At same time, our partial understanding quiescence reflects difficulty identify stable biomarkers/therapeutic targets control settings. This review focuses discoveries interrelated fields dormancy, stemness, resistance, discussing experimental evidences frame nonlinear dynamics approach, exploring possibility that may represent peril potential therapeutic resource.

Language: Английский

---

Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 20, 2024

Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.

Language: Английский

---

Biomimetic co-assembled nanodrug of doxorubicin and berberine suppresses chemotherapy-exacerbated breast cancer metastasis

Biomaterials, Journal Year: 2021, Volume and Issue: 271, P. 120716 - 120716

Published: Feb. 18, 2021

Language: Английский

---

The Impact of m6A RNA Modification in Therapy Resistance of Cancer: Implication in Chemotherapy, Radiotherapy, and Immunotherapy

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 10

Published: Feb. 25, 2021

m6A RNA methylation, which serves as a critical regulator of transcript expression, has gathered tremendous scientific interest in recent years. From processing to nuclear export, translation decay, modification been studied affect various aspects metabolism, and it is now considered one the most abundant epitranscriptomic modification. methyltransferases (writer), m6A-binding proteins (readers), demethylases (erasers) are frequently upregulated several neoplasms, thereby regulating oncoprotein augmenting tumor initiation, enhancing cancer cell proliferation, progression, metastasis. Though potential role methylation growth proliferation cells well documented, its development therapy resistance not clear. In this review, we focus on m6A-associated regulation, mechanisms, functions acquired chemoresistance, radioresistance, immunotherapy cancer.

Language: Английский

---