Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: June 13, 2023
The
epithelial-to-mesenchymal
transition
(EMT)
is
a
trans-differentiation
process
that
endows
epithelial
cells
with
mesenchymal
properties,
including
motility
and
invasion
capacity;
therefore,
its
aberrant
reactivation
in
cancerous
represents
critical
step
to
gain
metastatic
phenotype.
EMT
dynamic
program
of
cell
plasticity;
many
partial
states
can
be,
indeed,
encountered
the
full
inverse
mesenchymal-to-epithelial
(MET)
appears
fundamental
colonize
distant
secondary
sites.
EMT/MET
dynamics
granted
by
fine
modulation
gene
expression
response
intrinsic
extrinsic
signals.
In
this
complex
scenario,
long
non-coding
RNAs
(lncRNAs)
emerged
as
players.
This
review
specifically
focuses
on
lncRNA
HOTAIR,
master
regulator
plasticity
tumors.
Molecular
mechanisms
controlling
differentiated
well
trans-differentiated
are
highlighted
here.
Moreover,
current
knowledge
about
HOTAIR
pleiotropic
functions
regulation
both
protein
activities
described.
Furthermore,
relevance
specific
targeting
challenges
exploiting
for
therapeutic
approaches
counteract
discussed.
Journal of Advanced Research,
Journal Year:
2021,
Volume and Issue:
37, P. 91 - 106
Published: Oct. 6, 2021
Tumors
are
usually
refractory
to
anti-cancer
therapeutics
under
hypoxic
conditions.
However,
the
underlying
molecular
mechanism
remains
be
elucidated.
Our
study
intended
identify
hypoxia
inducible
lncRNAs
and
their
biological
function
in
gastric
cancer
(GC).
Differentially
expressed
were
determined
by
microarray
analysis
between
GC
cells
exposed
(1%
O2)
normoxia
(21%
for
24
h.
The
expression
level
of
CBSLR
was
manipulated
several
cell
lines
perform
analyses
both
vitro
vivo.
We
identified
a
hypoxia-induced
lncRNA-CBSLR
that
protected
from
ferroptosis,
leading
chem-resistance.
Mechanically,
interacted
with
YTHDF2
form
CBSLR/YTHDF2/CBS
signaling
axis
decreased
stability
CBS
mRNA
enhancing
binding
m6A-modified
coding
sequence
(CDS)
mRNA.
Furthermore,
levels,
methylation
ACSL4
protein
reduced,
polyubiquitination
degradation
ACSL4.
This,
turn,
pro-ferroptosis
phosphatidylethanolamine
(PE)
(18:0/20:4)
PE
(18:0/22:4)
content
contributed
ferroptosis
resistance.
Notably,
is
upregulated,
whereas
downregulated
tissues
compared
matched
normal
tissues;
patients
high
CBSLR/low
levels
have
worse
clinical
outcome
poorer
response
chemotherapy.
reveals
novel
how
HIF1α/CBSLR
modulates
ferroptosis/chemoresistance
GC,
illuminating
potential
therapeutic
targets
tumors.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2022,
Volume and Issue:
41(1)
Published: July 1, 2022
Abstract
Background
One
of
the
most
malignant
tumors
in
men
is
prostate
cancer
that
still
incurable
due
to
its
heterogenous
and
progressive
natures.
Genetic
epigenetic
changes
play
significant
roles
development.
The
RNA
molecules
with
more
than
200
nucleotides
length
are
known
as
lncRNAs
these
factors
do
not
encode
protein.
They
regulate
gene
expression
at
transcriptional,
post-transcriptional
levels.
LncRNAs
vital
biological
functions
cells
pathological
events,
hence
their
undergoes
dysregulation.
Aim
review
role
alterations
development
emphasized
here.
Therefore,
were
chosen
for
this
purpose
level
interaction
other
signaling
networks
progression
examined.
Key
scientific
concepts
aberrant
has
been
well-documented
rate
tumor
regulated
via
affecting
STAT3,
NF-κB,
Wnt,
PI3K/Akt
PTEN,
among
molecular
pathways.
Furthermore,
radio-resistance
chemo-resistance
features
cells.
Overexpression
tumor-promoting
such
HOXD-AS1
CCAT1
can
result
drug
resistance.
Besides,
induce
immune
evasion
upregulating
PD-1.
Pharmacological
compounds
quercetin
curcumin
have
applied
targeting
lncRNAs.
siRNA
tool
reduce
thereby
suppressing
progression.
Prognosis
diagnosis
clinical
course
be
evaluated
by
exosomal
lncRNA-p21
investigated
serum
patients
a
reliable
biomarker.
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 3, 2022
Distinct
regions
harboring
cancer
stem
cells
(CSCs)
have
been
identified
within
the
microenvironment
of
various
tumors,
and
as
in
case
their
healthy
counterparts,
these
anatomical
are
termed
"niche."
Thus
far,
a
large
volume
studies
shown
that
CSC
niches
take
part
maintenance,
regulation
renewal,
differentiation
plasticity
CSCs.
In
this
review,
we
summarize
discuss
latest
findings
regarding
niche
morphology,
physical
terrain,
main
signaling
pathways
interactions
them.
The
cellular
molecular
components
CSCs
also
involve
genetic
epigenetic
modulations
mediate
support
ultimately
leading
to
progression.
It
suggests
crosstalk
between
plays
an
important
role
therapy
resistance
recurrence.
addition,
updated
diverse
therapeutic
strategies
different
cancers
basic
research
clinical
trials
review.
Understanding
complex
heterogeneity
is
necessary
pre-requisite
for
designing
superior
target
CSC-specific
factors
and/or
niche.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(17), P. 7351 - 7370
Published: Jan. 1, 2022
Background:
Metastasis
is
the
leading
cause
of
death
in
patients
with
breast
cancer
(BC).
Primary
tumors
create
a
premetastatic
niche
(PMN)
secondary
organs
for
subsequent
metastases.
Cancer-associated
fibroblasts
(CAFs)
are
predominant
stromal
component
tumor
microenvironment
and
serve
as
major
contributor
to
metastasis.
However,
function
mechanism
primary
CAFs
remain
unclear
BC.
Methods:
We
investigated
expression
profiles
lncRNAs
pairs
NFs
derived
from
tissues
using
lncRNA
microarray.
The
levels
lncSNHG5,
ZNF281,
IGF2BP2,
CCL2
CCL5
were
assessed
by
qRT-PCR;
protein
related
genes
(e.g.,
CCL2,
CCL5)
analyzed
western
blotting
and/or
ELISA
immortalized
clinical
samples.
Tubule
formation
three-dimensional
sprouting
assays
tissue
fluorescence
staining
conducted
investigate
angiogenesis.
In
vitro
permeability
assays,
trans-endothelial
invasion
vivo
examine
vascular
permeability.
regulatory
lncSNHG5
was
RNA
sequencing,
fluorescent
situ
hybridization,
cellular
fractionation
assay,
mass
spectrometry,
pull-down,
immunoprecipitation,
gene-specific
m6A
chromatin
dual
luciferase
reporter
assay
actinomycin
D
treatment
NFs.
Results:
LncSNHG5
highly
expressed
played
an
essential
role
promoting
angiogenesis
leakiness
through
regulation
ZNF281
CAFs.
enhanced
mRNA
stability
binding
reader
IGF2BP2.
Enhanced
transcriptionally
regulated
activate
P38
MAPK
signaling
endothelial
cells.
High
associated
metastasis
poor
prognosis
BC
patients.
inhibitors
RS102895,
marasviroc
cenicriviroc
inhibited
PMN
blocking
CCL2/CCR2
CCL5/CCR5.
lncSNHG5-ZNF281-CCL2/CCL5
axis
plays
inducing
promote
Conclusions:
Our
work
demonstrates
that
its
downstream
ZNF281-CCL2/CCL5
play
crucial
may
potential
targets
diagnosis
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 18, 2023
Abstract
Cancer
stem
cells
(CSCs),
initially
identified
in
leukemia
1994,
constitute
a
distinct
subset
of
tumor
characterized
by
surface
markers
such
as
CD133,
CD44,
and
ALDH.
Their
behavior
is
regulated
through
complex
interplay
networks,
including
transcriptional,
post-transcriptional,
epigenetic,
microenvironment
(TME),
epithelial-mesenchymal
transition
(EMT)
factors.
Numerous
signaling
pathways
were
found
to
be
involved
the
regulatory
network
CSCs.
The
maintenance
CSC
characteristics
plays
pivotal
role
driving
CSC-associated
metastasis
conferring
resistance
therapy.
Consequently,
CSCs
have
emerged
promising
targets
cancer
treatment.
To
date,
researchers
developed
several
anticancer
agents
tailored
specifically
target
CSCs,
with
some
these
treatment
strategies
currently
undergoing
preclinical
or
clinical
trials.
In
this
review,
we
outline
origin
biological
explore
networks
governing
discuss
implicated
investigate
influential
factors
contributing
therapy
Finally,
offer
insights
into
designed
eliminate
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
15
Published: April 26, 2024
LncRNAs
are
an
essential
type
of
non-coding
RNAs,
which
have
been
reported
to
be
involved
in
various
human
pathological
conditions.
Increasing
evidence
suggests
that
drugs
can
regulate
lncRNAs
expression,
makes
it
possible
develop
as
therapeutic
targets.
Thus,
developing
Molecular Therapy — Nucleic Acids,
Journal Year:
2021,
Volume and Issue:
25, P. 613 - 637
Published: Aug. 19, 2021
Breast
cancer
is
a
malignant
tumor
that
has
high
mortality
rate
and
mostly
occurs
in
women.
Although
significant
progress
been
made
the
implementation
of
personalized
treatment
strategies
for
molecular
subtypes
breast
cancer,
therapeutic
response
often
not
satisfactory.
Studies
have
reported
long
non-coding
RNAs
(lncRNAs)
are
abnormally
expressed
closely
related
to
occurrence
development
cancer.
In
addition,
tissue
cell-type
specificity
makes
lncRNAs
particularly
attractive
as
diagnostic
biomarkers,
prognostic
factors,
specific
targets.
Therefore,
an
in-depth
understanding
regulatory
mechanisms
essential
developing
new
strategies.
this
review,
we
systematically
elucidate
general
characteristics,
potential
mechanisms,
targeted
therapy
discuss
emerging
functions
Additionally,
also
highlight
advantages
challenges
using
biomarkers
diagnosis
or
targets
drug
resistance
present
future
perspectives
clinical
practice.
Nucleic Acids Research,
Journal Year:
2022,
Volume and Issue:
51(D1), P. D199 - D207
Published: Nov. 2, 2022
Abstract
An
updated
LncTarD
2.0
database
provides
a
comprehensive
resource
on
key
lncRNA–target
regulations,
their
influenced
functions
and
lncRNA-mediated
regulatory
mechanisms
in
human
diseases.
is
freely
available
at
(http://bio-bigdata.hrbmu.edu.cn/LncTarD
or
https://lnctard.bio-database.com/).
was
with
several
new
features,
including
(i)
an
increased
number
of
disease-associated
lncRNA
entries,
where
the
current
release
8360
419
disease
subtypes
1355
lncRNAs;
(ii)
predicted
3312
out
regulations
as
potential
diagnostic
therapeutic
biomarkers
circulating
tumor
cells
(CTCs);
(iii)
addition
536
new,
experimentally
supported
that
modulate
properties
cancer
stem
cells;
(iv)
clinical
application
section
2894
for
application.
Importantly,
RNA-seq/microarray
single-cell
web
tools
customizable
analysis
visualization
tool
used
to
mining
both
tissue
samples
CTCs
blood
samples.
The
provide
annotation
from
perspectives
pan-cancer
cancer-specific
level.
will
be
useful
investigation
deregulation
disease.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: May 5, 2023
Epithelial-to-mesenchymal
transition
(EMT)
and
cancer
stem-like
cells
(CSLCs)
play
crucial
role
in
tumor
metastasis
drug-resistance.
Disheveled3
(DVL3)
is
involved
malignant
behaviors
of
cancer.
However,
the
potential
mechanism
DVL3
remain
elusive
EMT
CSLCs
colorectal
(CRC).