Aquaculture, Journal Year: 2023, Volume and Issue: 579, P. 740228 - 740228
Published: Oct. 16, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 5, 2024
Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.
Language: Английский
Citations
85
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 223, P. 116154 - 116154
Published: March 19, 2024
Wnt signaling pathways are highly conserved cascades that mediate multiple biological processes through canonical or noncanonical pathways, from embryonic development to tissue maintenance, but they also contribute the pathogenesis of numerous cancers. Recent studies have revealed critically control interplay between cancer cells and tumor-associated macrophages (TAMs) in tumor microenvironment (TME) potentially impact efficacy immunotherapy. In this review, we summarize evidence boost maturation infiltration for immune surveillance steady state polarize TAMs toward immunosuppressive M2-like phenotypes escape TME. Both utilize transmit signals, interaction is crucial carcinogenesis progression common solid cancers, such as colorectal, gastric, hepatocellular, breast, thyroid, prostate, kidney, lung cancers; osteosarcoma; glioma. Specifically, compared with those play a distinct role leukemia. Efforts develop Wnt-based drugs treatment still ongoing, some indeed enhance anticancer response. We believe combination signaling-based therapy conventional therapies promising therapeutic approach can facilitate personalized most
Language: Английский
Citations
14
Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155391 - 155391
Published: Feb. 21, 2024
Colorectal cancer (CRC) is one of the commonest cancers worldwide. Metastasis most common cause death in patients with CRC. Arenobufagin an active component bufadienolides, extracted from toad skin and parotid venom. reportedly inhibits epithelial-to-mesenchymal transition (EMT) metastasis various cancers. However, mechanism through which arenobufagin CRC remains unclear.
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9463 - 9463
Published: Aug. 30, 2024
Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential
Language: Английский
Citations
9
Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155402 - 155402
Published: Feb. 1, 2024
Vasculogenic mimicry (VM) is an angiogenesis-independent process that potentially contributes to the poor clinical outcome of anti-angiogenesis therapy in multiple malignant cancers, including pancreatic adenocarcinoma (PAAD). Several studies have shown ginsenoside Rg3, a bioactive component ginseng, holds considerable potential for cancer treatment. Our previous work has proved Rg3 can inhibit VM formation PAAD. However, its underlying mechanism remains unclear.
Language: Английский
Citations
7
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: Feb. 9, 2024
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation SOX members closely associated tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research investigate mechanisms functions confusion remains regarding aspects such as immune microenvironment (TIME) contradictory impacts exerts on tumors. This review summarizes physiological function multiple roles tumors, focus relationship between TIME, aiming propose potential cancer promising methods for treatment.
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4140 - 4140
Published: April 9, 2024
Despite incessant research, colorectal cancer (CRC) is still one of the most common causes fatality in both men and women worldwide. Over time, advancements medical treatments have notably enhanced survival rates patients with cancer. Managing metastatic CRC involves a complex tradeoff between potential benefits adverse effects treatment, considering factors like disease progression, treatment toxicity, drug resistance, overall impact on patient's quality life. An increasing body evidence highlights significance stem cell (CSC) concept, proposing that CSCs occupy central role triggering been focal point extensive research variety types, including CRC. Colorectal cells (CCSCs) play crucial tumor initiation, metastasis, therapy making them targets. Various methods exist for isolating CCSCs, understanding mechanisms resistance associated crucial. This paper offers an overview current pertaining to comprehension
Language: Английский
Citations
7
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: Aug. 1, 2024
Abstract Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal (EMP). cells with EMP manifest in three states as transition (EMT), partial EMT, mesenchymal–epithelial transition, orchestrate switch heterogeneity tumor via transcriptional regulation series signaling pathways, transforming growth factor‐β, Wnt/β‐catenin, Notch. However, due complicated nature EMP, diverse process not fully understood. In this review, we systematically conclude biological background, regulating mechanisms well role therapy response. We also summarize range small molecule inhibitors, immune‐related approaches, combination therapies that have been developed target for outstanding EMP‐driven deterioration. Additionally, explore potential technique EMP‐based mechanistic investigation research, may burst vigorous prospects. Overall, elucidate multifaceted aspects progression suggest promising direction treatment based on targeting EMP.
Language: Английский
Citations
4
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 20, 2025
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 267, P. 155837 - 155837
Published: Feb. 11, 2025
Language: Английский
Citations
0