Chemokines in colon cancer progression

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 400 - 407

Published: Feb. 7, 2022

Language: Английский

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Living Leukocyte‐Based Drug Delivery Systems

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(17)

Published: Nov. 1, 2022

Abstract Leukocytes play a vital role in immune responses, including defending against invasive pathogens, reconstructing impaired tissue, and maintaining homeostasis. When the system is activated vivo, leukocytes accomplish series of orderly complex regulatory processes. While cancer inflammation‐related diseases like sepsis are critical medical difficulties plaguing humankind around world, have been shown to largely gather at focal site, significantly contribute inflammation progression. Therefore, living leukocyte‐based drug delivery systems attracted considerable attention recent years due innate specific targeting effect, low immunogenicity, improved therapeutic efficacy, reverse effect. In this review, advances development macrophages, neutrophils, lymphocytes as promising treatment strategies for introduced. The advantages, current challenges, limitations these also discussed, well perspectives on future precision targeted therapy clinics provided. Collectively, it expected that such kind cell‐based improve or even revolutionize treatments cancers clinics.

Language: Английский

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New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(7), P. 739 - 776

Published: May 17, 2023

Abstract Over the past thirty years, importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine interactions with trigger signaling pathway activity to form a network fundamental diverse immune processes, including host homeostasis responses disease. Genetic nongenetic regulation both expression structure conveys chemokine functional heterogeneity. Imbalances defects in system contribute pathogenesis variety diseases, cancer, inflammatory metabolic neurological disorders, which render focus studies aiming discover therapies important biomarkers. The integrated view biology underpinning divergence plasticity provided insights into dysfunction disease states, including, among others, coronavirus 2019 (COVID-19). In this review, by reporting latest advances results from analyses plethora sequencing-based datasets, we outline recent understanding genetic variations heterogeneity provide an updated contribution pathophysiological network, focusing on chemokine-mediated inflammation cancer. Clarification molecular basis dynamic chemokine-receptor will help advance achieve precision medicine application clinic.

Language: Английский

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Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 85, P. 155 - 163

Published: July 24, 2021

Cancer metastasis is a major reason for the cancer-associated deaths and role of long non-coding RNAs (lncRNAs) in cancer increasingly being realized. Among many oncogenic pathways, NF-κB signalling's involvement as key inflammation-regulatory transcription factor has been subject interest time. Accumulating data from vitro well vivo studies along with analysis clinical tissues points to regulation signalling by lncRNAs implications toward onset metastasis. LncRNAs FOXD2-AS1, KRT19P3 interacting lncRNA (NKILA) associate lymph node poor prognosis individual cancers. The epithelial-mesenchymal transition (EMT) known. EMT regulated NF-κB/EMT-induced remains hot topic research indications such roles MALAT1, SNHG15, CRNDE AC007271.3. lncRNAs, NKILA stands out most investigated its NF-κB. This tumor suppressive reported downregulated samples representing different human Mechanistically, consistently shown inhibit activation via inhibition IκBα phosphorylation resulting suppression EMT. also target natural anticancer compounds. Given importance master regulatory factor, modulators signaling, can provide alternate targets metastatic cancers constitutively active

Language: Английский

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Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 697 - 708

Published: March 26, 2022

Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years possible role in cancer progression pathogenesis. Evidence emerging from clinical studies recent further established diagnostic as well prognostic importance of signaling. SDF-1 are routinely reported to be elevated tumors, distant metastases, which correlates with poor survival patients. These findings have kindled interest the mechanisms that regulate CXCR4/SDF-1 expression. Of note, there is a particular epigenetic regulation signaling may responsible upregulated primary metastatic cancers. This review first lists evidence supporting putative and/or biomarker, followed by discussion on affect include non-coding RNAs, such as, microRNAs, long RNAs circular RNAs. Additionally, we also discuss expression through methylation acetylation. Better understanding appreciation can invariably lead identification novel therapeutic targets therapies this oncogenic

Language: Английский

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Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 92, P. 74 - 83

Published: April 11, 2023

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cells indefinitely perpetuate as well differentiate. stem cell populations within a growing tumor also help evade inhibitory effects chemo- radiation-therapies, in addition playing an important role metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with stemness, thus presenting attractive targets for therapy. The interest non-coding RNAs (ncRNAs) recent years has provided further insight into mechanisms by which TFs influence characteristics. There evidence direct regulation ncRNAs, such as, microRNAs (miRNAs), (lncRNAs) circular (circRNAs), vice versa. Additionally, TF-ncRNAs regulations often indirect, involving ncRNA-target genes or sponging other ncRNA species individual ncRNAs. information rapidly evolving this review provides comprehensive interactions implications on stemness response therapies. Such knowledge will uncover many levels tight control providing novel opportunities therapy process.

Language: Английский

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The MiR-320 Family Is Strongly Downregulated in Patients with COVID-19 Induced Severe Respiratory Failure

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10351 - 10351

Published: Sept. 26, 2021

A high incidence of thromboembolic events associated with mortality has been reported in severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections failure. The present study characterized post-transcriptional gene regulation by global microRNA (miRNA) expression relation to activated coagulation and inflammation 21 critically ill SARS-CoV-2 patients. cohort consisted patients moderate failure (n = 11) 10) at an stage (day 0-3) the later course disease (>7 days). All needed supplemental oxygen were defined requirement positive pressure ventilation (intubation). Levels D-dimers, partial thromboplastin time (aPTT), C-reactive protein (CRP), interleukin (IL)-6 significantly higher compared Concurrently, next generation sequencing (NGS) analysis demonstrated increased dysregulation miRNA progression severity connected extreme downregulation miR-320a, miR-320b miR-320c. Kyoto encyclopedia genes genomes (KEGG) pathway revealed involvement Hippo signaling pathway, transforming growth factor (TGF)-β adherens junctions. all miR-320 family members was correlated CRP, IL-6, D-dimer levels. In conclusion, our underlines importance processes emphasizes miRNA-320s as potential biomarkers for progressive infection.

Language: Английский

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Epigenetic control of inflammation in Atopic Dermatitis

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 154, P. 199 - 207

Published: April 27, 2023

Atopic dermatitis (AD), also known as atopic eczema, is a common but complex chronic, itchy skin condition with underlying inflammation of the skin. This ailment prevalent worldwide and affects people all ages, particularly children below five years age. The itching resulting rashes in AD patients are often result inflammatory signals, thus necessitating closer look at inflammation-regulating mechanisms for putative relief, care therapy. Several chemical- well genetically-induced animal models have established importance targeting pro-inflammatory microenvironment. Epigenetic gaining attention towards better understanding onset progression inflammation. physiological processes implications pathophysiology AD, such as, barrier dysfunction either due to reduced filaggrin / human β‐defensins or altered microbiome, reprograming Fc receptors overexpression high affinity IgE receptors, elevated eosinophil numbers IL-22 production by CD4 + T cells epigenetic that include differential promoter methylation and/or regulation non-coding RNAs. Reversing these changes has been verified reduce burden through secretion cytokines IL-6, IL-4, IL-13, IL-17, etc, benefit against experimental models. A thorough remodeling potential opening avenues novel diagnostic, prognostic therapeutic options.

Language: Английский

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Mediation of association between benzo[a]pyrene exposure and lung cancer risk by plasma microRNAs: A Chinese case-control study

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 115980 - 115980

Published: Jan. 22, 2024

Epidemiologic studies have reported the positive relationship of benzo[a]pyrene (BaP) exposure with risk lung cancer. However, mechanisms underlying is still unclear. Plasma microRNA (miRNA) a typical epigenetic biomarker that was linked to environment and cancer development. We aimed reveal mediation effect plasma miRNAs on BaP-related designed case-control study including 136 patients controls, measured adducts diol epoxide-albumin (BPDE-Alb) sequenced miRNA profiles in plasma. The relationships between BPDE-Alb adducts, normalized levels were assessed by linear regression models. effects investigated. A total 190 significantly related status at Bonferroni adjusted P < 0.05, among which 57 showed different |fold change| > 2 samples before after tumor resection surgery 0.05. Especially, cancer-associated miRNAs, miR-17–3p, miR-20a-3p, miR-135a-5p, miR-374a-5p, miR-374b-5p, miR-423–5p miR-664a-5p, could turn mediate separate 42.2%, 33.0%, 57.5%, 36.4%, 48.8%, 32.5% 38.2% Our results provide non-invasion candidates for cancer, highlight dysregulation as potential intermediate mechanism BaP lead tumorigenesis.

Language: Английский

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Spray-Dried Nanolipid Powders for Pulmonary Drug Delivery: A Comprehensive Mini Review

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 680 - 680

Published: May 17, 2024

Lung diseases have received great attention in the past years because they contribute approximately one-third of total global mortality. Pulmonary drug delivery is regarded as one most appealing routes to treat lung diseases. It addresses numerous drawbacks linked traditional dosage forms. presents notable features, such as, for example, a non-invasive route, localized delivery, low enzymatic activity, degradation, higher patient compliance, and avoiding first-pass metabolism. Therefore, pulmonary route commonly explored delivering drugs both locally systemically. Inhalable nanocarrier powders, especially, lipid nanoparticle formulations, including solid-lipid nanostructured-lipid nanocarriers, are attracting considerable interest addressing respiratory thanks their significant advantages, deep deposition, biocompatibility, biodegradability, mucoadhesion, controlled released. Spray drying scalable, fast, commercially viable technique produce nanolipid powders. This review highlights ideal criteria inhalable spray-dried SLN NLC powders administration route. Additionally, promising inhalation devices, known dry powder inhalers (DPIs) powder-based medications, applications treating chronic conditions, considered.

Language: Английский

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