Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 639 - 652
Published: Sept. 4, 2024
Language: Английский
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)
Published: Feb. 8, 2023
Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.
Language: Английский
Citations
89
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: July 12, 2023
Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.
Language: Английский
Citations
51
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 571 - 608
Published: Jan. 1, 2024
Abstract: With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from body, and nonspecific targeting, which hampered their clinical application. Therefore, novel systems with improved biocompatibility high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug system (BNDDS) has become research hotspot focus in field life sciences. This new platform uses bio-nanotechnology to encapsulate synthetic NPswithin membrane, organically integrating immunogenicity, toxicity, tumor good adjustability versatility nanocarrier, shows promising applications precision therapy. this review, we systematically summarize progress BNDDS used for optimizing delivery, providing theoretical reference designing safe efficient treatment strategies improve outcomes. Keywords: nanoparticles, cell targeted therapy
Language: Английский
Citations
35
Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)
Published: March 9, 2024
Abstract The precise targeted delivery of therapeutic agents to deep regions the brain is crucial for effective treatment various neurological diseases. However, achieving this goal challenging due presence blood‒brain barrier (BBB) and complex anatomy brain. Here, a biomimetic self‐propelled nanomotor with cascade targeting capacity developed inflammatory nanomotors are designed asymmetric structures mesoporous SiO 2 head multiple MnO tentacles. Macrophage membrane modification endows BBB penetration abilities catalyze degradation H O into , not only by reducing inflammation but also providing driving force penetration. Additionally, loaded curcumin, which actively regulates macrophage polarization from M1 M2 phenotype. All in vitro cell, organoid model, vivo animal experiments confirmed effectiveness targeting, penetration, anti‐inflammatory, nervous system function maintenance. Therefore, study introduces platform ability active
Language: Английский
Citations
31
Science Advances, Journal Year: 2024, Volume and Issue: 10(15)
Published: April 10, 2024
Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and ferroptosis, offering promising solutions to enduring challenges oncology. Here, we have engineered Cellular Trojan Horse, named MetaCell, which uses live neutrophils stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs (Lip@Fe-Cu-MOFs). MetaCell instigate thereby enhancing treatment efficacy. Mirroring the characteristics neutrophils, evade immune system not only infiltrate tumors but also respond inflammation by releasing therapeutic components, surmounting traditional barriers. Notably, Lip@Fe-Cu-MOFs demonstrate notable photothermal effects, inciting targeted release Fe-Cu-MOFs within cancer cells amplifying action ferroptosis. has demonstrated outcomes tumor-bearing mice, effectively eliminating solid forestalling recurrence, leading extended survival. This research provides great insights into complex between copper iron homeostasis malignancies, potentially paving way for innovative approaches treatment.
Language: Английский
Citations
27
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 55 - 72
Published: April 23, 2024
As a natural immune cell and antigen presenting cell, macrophages have been studied engineered to treat human diseases. Macrophages are well-suited for use as drug carriers because of their biological characteristics, such excellent biocompatibility, long circulation, intrinsic inflammatory homing phagocytosis. Meanwhile, macrophages' uniquely high plasticity easy re-education polarization facilitates part efficacious therapeutics the treatment diseases or tumors. Although recent studies demonstrated promising advances in macrophage-based delivery, several challenges currently hinder further improvement therapeutic effect clinical application. This article focuses on main utilizing from selection macrophage sources, loading, maintenance phenotypes, migration release at target sites. In addition, corresponding strategies insights related these described. Finally, we also provide perspective shortcomings road translation production.
Language: Английский
Citations
19
Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)
Published: Oct. 28, 2023
Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.
Language: Английский
Citations
39
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114840 - 114840
Published: April 22, 2023
Language: Английский
Citations
28
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(19)
Published: Feb. 12, 2023
Abstract Living cell‐based drug delivery systems (LC‐DDSs) are limited by adverse interactions between drugs and carrier cells, typically drug‐induced toxicity to cells restriction of on release. Here, a method is established adsorb nanocarriers externally living thereby reducing cytotoxicity caused uptake realizing improved release at the disease site. It found that divalent metal ion‐phenolic network (MPN) affords adhesion poly (lactic‐co‐glycolic acid) nanoparticles onto macrophage (Mφ) surfaces with minimized intracellular no negative effect cell proliferation. On this basis, an Mφ‐DDS doxorubicin‐loaded surface (DOX‐NP@Mφ) constructed. Compared loading via endocytosis, well‐maintains bioactivity (viability migration chemotaxis) cell. By virtue photothermal MPN tumor site, DOX‐NP‐associated vesicles liberated for chemotherapy. This facile, benign, efficient (ice bath, 2 min) extracellular nanoparticle attachment minimizing provides platform technology LC‐DDS development.
Language: Английский
Citations
26
Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1470 - 1470
Published: Feb. 3, 2023
Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular with tunable physicochemical properties, self-healing, externally stimulated responses. Among them, pillararene-based show great potential for biomedical applications fascinating host–guest easy modification. Herein, we summarize the state art cancer therapy illustrate its developmental trend future perspective.
Language: Английский
Citations
24