NF-κB in biology and targeted therapy: new insights and translational implications

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 4, 2024

Abstract NF-κB signaling has been discovered for nearly 40 years. Initially, was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have that its role can be expanded to variety of mechanisms, biological processes, human diseases, treatment options. In this review, we first scrutinize the research process signaling, summarize composition, activation, regulatory mechanism signaling. We investigate interaction other important pathways, including PI3K/AKT, MAPK, JAK-STAT, TGF-β, Wnt, Notch, Hedgehog, TLR The physiological pathological states well intricate involvement inflammation, immune regulation, tumor microenvironment, are also explicated. Additionally, illustrate how is involved cancers, autoimmune cardiovascular metabolic neurological COVID-19. Further, discuss therapeutic approaches targeting IKK inhibitors, monoclonal antibodies, proteasome nuclear translocation DNA binding TKIs, non-coding RNAs, immunotherapy, CAR-T. Finally, provide an outlook field hope present stereoscopic, comprehensive will inform future clinical practice.

Language: Английский

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NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

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lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 9, 2024

Language: Английский

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LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(2), P. 718 - 732

Published: Jan. 1, 2024

As a crucial protumorigenic long noncoding RNA, colorectal tumor differential expression (CRNDE) has been confirmed to facilitate the progression of various cancers.However, its role in microenvironment (TME) hepatocellular carcinoma (HCC) is still unclear.Here we determined that CRNDE was upregulated HCC samples and CRNDE-positive cells were predominantly enriched malignant cells.In vivo functional assays revealed CRNDE-induced supported progression, recruited abundant granulocyte myeloid-derived suppressor (G-MDSCs) restricted infiltration T terms mechanisms, bound with Toll-like receptor 3 (TLR3) activated NF-κB signaling increase secretion c-x-c motif chemokine ligand (CXCL3).CRNDE knockdown could significantly suppress accumulation G-MDSCs enhance TME vivo.Taken together, our study reveals CRNDE-NF-κB-CXCL3 axis plays driving immunosuppressive niche by recruiting G-MDSCs.

Language: Английский

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The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10337 - 10337

Published: June 19, 2023

Glioblastoma multiforme (GBM) is the most common and invasive primary central nervous system tumor in humans, accounting for approximately 45–50% of all brain tumors. How to conduct early diagnosis, targeted intervention, prognostic evaluation GBM, order improve survival rate glioblastoma patients, has always been an urgent clinical problem be solved. Therefore, a deeper understanding molecular mechanisms underlying occurrence development GBM also needed. Like many other cancers, NF-κB signaling plays crucial role growth therapeutic resistance GBM. However, mechanism high activity remains elucidated. This review aims identify summarize involved recent pathogenesis as well basic therapy via signaling.

Language: Английский

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MiRNAs as new potential biomarkers and therapeutic targets in brain metastasis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 678 - 686

Published: Feb. 23, 2024

Brain metastases represent a formidable challenge in cancer management, impacting significant number of patients and contributing significantly to cancer-related mortality. Conventional diagnostic methods frequently fall short, underscoring the imperative for non-invasive alternatives. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs) long non-coding (lncRNAs), present promising avenues exploration. These ncRNAs exert influence over prognosis treatment resistance brain metastases, offering valuable insights into underlying mechanisms potential therapeutic targets. Dysregulated have been identified originating from various primary cancers, unveiling opportunities intervention prevention. The analysis ncRNA expression bodily fluids, such as serum cerebrospinal fluid, provides noninvasive means differentiate tumors. NcRNAs, particularly miRNAs, assume pivotal role orchestrating immune response within microenvironment. MiRNAs exhibit promise diagnosing effectively distinguishing between normal cells, pinpointing tissue origin metastatic manipulation miRNAs holds substantial treatment, prospect reducing toxicity enhancing efficacy. Given limited options threat patients, RNAs, especially emerge beacons hope, serving both tools Further clinical studies are validate specificity sensitivity ncRNAs, potentially reshaping approaches tackle this elevate outcomes affected patients.

Language: Английский

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Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats

Cardiovascular Toxicology, Journal Year: 2021, Volume and Issue: 22(2), P. 152 - 166

Published: Nov. 27, 2021

Language: Английский

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MIR503HG: A potential diagnostic and therapeutic target in human diseases

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114314 - 114314

Published: Feb. 2, 2023

LncRNAs are involved in many physiological and pathological processes, including chromatin remodeling, transcription, posttranscriptional gene expression, mRNA stability, translation, posttranslational modification, their functions depend on subcellular localization. MIR503HG is a lncRNA as well host for the miRNAs miR-503 miR-424. independently or synergistically with miR-503. affects cell proliferation, invasion, metastasis, apoptosis, angiogenesis, other biological behaviors. The mechanism of disease includes interaction protein, sponging miRNA to regulate downstream target gene, participation NF-κB, TGF-β, ERK/MAPK, PI3K/AKT signaling pathways. In this review, we summarize molecular mechanisms its potential applications diagnosis, prognosis, treatment. We also raise some unanswered questions area, providing insights future research.

Language: Английский

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The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 463 - 470

Published: Jan. 9, 2024

In the dynamic realm of molecular biology and biomedical research, significance long non-coding RNAs (lncRNAs) acting as competing endogenous (ceRNAs) continues to grow, encompassing a broad spectrum both physiological pathological conditions. Particularly noteworthy is their pivotal role in intricate series events leading development hepatic fibrosis, where stellate cells (HSCs) play central role. Recent strides scientific exploration have unveiled involvement lncRNAs ceRNAs orchestrating activation HSCs. This not only deepens our comprehension functioning proteins, DNA, extensive array coding noncoding but also sheds light on interactions among these molecules. Furthermore, well-established ceRNA networks, involving classical between lncRNAs, microRNAs (miRNAs), messenger (mRNAs), are mere bystanders; they actively participate instigating advancing liver fibrosis. underscores pressing need for additional thorough research fully grasp potential ceRNA. The unyielding pursuit knowledge this field remains potent driving force with capacity enhance quality life numerous individuals grappling such diseases. It holds promise ushering new era precision medicine, signifying relentless dedication unraveling intricacies that could pave way transformative advancements diagnosis treatment

Language: Английский

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Ficus pumila fruit polysaccharide alleviates OVA-induced allergic asthma mice through the MAPK/NF-κB signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105827 - 105827

Published: Jan. 1, 2025

Language: Английский

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