Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Language: Английский
Molecules, Journal Year: 2022, Volume and Issue: 27(10), P. 3286 - 3286
Published: May 20, 2022
Berry-derived polyphenols are bioactive compounds synthesized and secreted by several berry fruits. These feature a diversity of chemical compounds, including phenolic acids flavonoids. Here, we report the beneficial health effects berry-derived their therapeutical application on gut-microbiota-related diseases, inflammation cancer. Pharmacokinetic investigations have confirmed absorption, availability, metabolism polyphenols. In vitro in vivo tests, as well clinical trials, showed that can positively modulate gut microbiota, inhibiting cancer development. Indeed, these inhibit growth pathogenic bacteria also promote bacteria. Moreover, exhibit therapeutic against different disorders such inflammation, cancer, metabolic disorders. manage via various mechanisms, particular inhibition transcriptional factor Nf-κB. shown remarkable types colorectal, breast, esophageal, prostate certain diabetes atherosclerosis were managed through mechanisms. data from berries promising source capable modulating intestinal therefore managing associated diseases. However, further should be carried out to determine mechanisms action polyphenol validate safety examinate uses.
Language: Английский
Citations
70
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6939 - 6939
Published: April 8, 2023
The human body is vastly colonised by microorganisms, whose impact on health increasingly recognised. genital tract hosts a diverse microbiota, and an increasing number of studies the male microbiota suggest that bacteria have role in infertility pathological conditions, such as prostate cancer. Nevertheless, this research field remains understudied. study bacterial colonisation highly impacted invasive nature sampling low abundance microbiota. Therefore, most relied analysis semen to describe (MGT), which was thought be sterile. aim narrative review present results used next-generation sequencing (NGS) profile patterns different anatomical compartments critically highlight their findings weaknesses. Moreover, we identified potential axes may crucial for our understanding its pathophysiology.
Language: Английский
Citations
28
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Prostate cancer was the fourth most diagnosed worldwide in 2022. Radical treatments and androgen deprivation therapy benefit newly patients but impact quality of life, often leading to castration-resistant prostate cancer. Short-term dietary changes significantly affect gut microbiota, which differs markedly between healthy individuals, impacting both progression treatment response. A high-choline diet increases risk fatal cancer, potentially mediated by conversion choline trimethylamine N-oxide (TMAO) microbiota. The CCK8 assay employed investigate whether TMAO affects proliferation ability cells determine appropriate drug concentration. Subsequently, time gradients, colony formation assays, EdU assays measured TMAO's influence on cell proliferation. Wound healing transwell migration evaluated effect migration. RNA-seq analysis performed explore mechanisms influences cells. qPCR Western blotting were utilized validate expression related mRNA or proteins. Finally, we vivo experiments evaluate a high growth subcutaneous tumors lung metastases mice. Our study found that enhances upregulating HMOX1 via activation MAPK signaling pathway, specifically p38 MAPK. In mouse tumor metastatic experiments, increased migration, resulting greater volume number than controls. This is first demonstrate role microbiota-derived metabolite promotes activating pathway increasing expression. Reducing intake through intervention may delay onset presenting significant clinical application value.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 10, 2025
Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely terminal product but also nexus for initiating physiological pathological responses body. Lysine lactylation (Kla), novel post-translational modification (PTM) proteins, has emerged pivotal mechanism by which exerts regulatory influence. This epigenetic potential alter gene expression patterns, thereby impacting Increasing evidence indicates correlation between adverse prognosis various malignancies. Consequently, this review article aims encapsulate proteins interact with lactate, elucidate tumorigenesis progression, explore therapeutic targets afforded modulation lactylation. The objective is clarify oncogenic provide strategic framework future directions burgeoning field.
Language: Английский
Citations
1
BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 18, 2025
Bone metastases (BM) represent a prevalent complication of tumors. Early and accurate diagnosis, however, is significant hurdle for radiologists. Recently, artificial intelligence (AI) has emerged as valuable tool to assist radiologists in the detection BM. This meta-analysis was undertaken evaluate AI diagnostic accuracy Two reviewers performed an exhaustive search several databases, including Wei Pu (VIP) database, China National Knowledge Infrastructure (CNKI), Web Science, Cochrane Library, Ovid-Embase, Ovid-Medline, Wan Fang Biology Medicine (CBM), from their inception December 2024. focused on studies that developed and/or validated techniques detecting BM magnetic resonance imaging (MRI) or computed tomography (CT). A hierarchical model used calculate odds ratio (DOR), negative likelihood (NLR), positive (PLR), area under curve (AUC), specificity (SP), pooled sensitivity (SE). The risk bias applicability were assessed using Prediction Model Risk Bias Assessment Tool (PROBAST), while Transparent Reporting multivariable prediction individual prognosis diagnosis-artificial (TRIPOD-AI) employed evaluating quality evidence. review covered 20 articles, among them, 16 included meta-analysis. results revealed SE 0.88 (0.82–0.92), SP 0.89 (0.84–0.93), AUC 0.95 (0.92–0.96), PLR 8.1 (5.57–11.80), NLR 0.14 (0.09–0.21) DOR 58 (31–109). When focusing algorithms. Based ML, (0.77–0.92), 0.93 (0.91–0.95). DL, (0.81–0.95), (0.81–0.94), (0.93–0.97). underscores substantial value identifying Nevertheless, in-depth large-scale prospective research should be carried out confirming AI's clinical utility management.
Language: Английский
Citations
1
APOPTOSIS, Journal Year: 2023, Volume and Issue: 29(1-2), P. 142 - 153
Published: Sept. 12, 2023
Language: Английский
Citations
22
International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110466 - 110466
Published: June 11, 2023
Language: Английский
Citations
19
Translational Oncology, Journal Year: 2024, Volume and Issue: 52, P. 102255 - 102255
Published: Dec. 24, 2024
Language: Английский
Citations
6
Cell Reports Medicine, Journal Year: 2023, Volume and Issue: 4(3), P. 100981 - 100981
Published: March 1, 2023
The origin, composition, and significance of the distal male urethral microbiome are unclear, but vaginal dysbiosis is linked to new sex partners several urogynecological syndromes. We characterized 110 specimens from men without symptoms, infections, or inflammation using shotgun metagenomics. Most contain characteristic lactic acid bacteria Corynebacterium spp. In contrast, associated with were present only in who reported intercourse. Sexual behavior, not other evaluated behavioral, demographic, clinical variables, strongly inter-specimen variance composition. Thus, urethra supports a simple core that established independent sexual exposures can be re-shaped by sex. Overall, results suggest urogenital microbiology behavior inexorably intertwined, show harbors female pathobionts.
Language: Английский
Citations
15
Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 39, P. 100792 - 100792
Published: Jan. 1, 2024
One of the cancers that affect men, prostate cancer considerably raises mortality rates for males around world. Patients with can have a localized or advanced form illness. Digital rectal examinations, prostate-specific antigen analyses, and biopsies are all used to identify cancer. The onset, development, spread correlated mutations in specific genes. Radical prostatectomy, ablative radiation, active surveillance forms treatment Androgen deprivation therapy (ADT), chemotherapy given men who metastatic experienced relapse. When compared traditional chemotherapeutic methods, liposome-based drug delivery technology offers less toxic, biodegradable, biocompatible nanomedicine. Liposomes offer great advantages use nanomedicines by improving sensitivity, specificity, persistence these anti-malignant cell agents body. Liposomal formulations undergoing clinical trials variety including present narrative review describes composition types liposomes, its advantages, disadvantages, methods preparation, research studies, applications, repurposing administration.
Language: Английский
Citations
5