Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1 DOI
Xujun You,

H X Li,

Qixin Li

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

Chemical Compounds of Berry-Derived Polyphenols and Their Effects on Gut Microbiota, Inflammation, and Cancer DOI Creative Commons
Abdelhakim Bouyahya, Nasreddine El Omari, Naoufal El Hachlafi

и другие.

Molecules, Год журнала: 2022, Номер 27(10), С. 3286 - 3286

Опубликована: Май 20, 2022

Berry-derived polyphenols are bioactive compounds synthesized and secreted by several berry fruits. These feature a diversity of chemical compounds, including phenolic acids flavonoids. Here, we report the beneficial health effects berry-derived their therapeutical application on gut-microbiota-related diseases, inflammation cancer. Pharmacokinetic investigations have confirmed absorption, availability, metabolism polyphenols. In vitro in vivo tests, as well clinical trials, showed that can positively modulate gut microbiota, inhibiting cancer development. Indeed, these inhibit growth pathogenic bacteria also promote bacteria. Moreover, exhibit therapeutic against different disorders such inflammation, cancer, metabolic disorders. manage via various mechanisms, particular inhibition transcriptional factor Nf-κB. shown remarkable types colorectal, breast, esophageal, prostate certain diabetes atherosclerosis were managed through mechanisms. data from berries promising source capable modulating intestinal therefore managing associated diseases. However, further should be carried out to determine mechanisms action polyphenol validate safety examinate uses.

Язык: Английский

Процитировано

70

Human Male Genital Tract Microbiota DOI Open Access

Arnaud Zuber,

Adriana Peric,

Nicola Pluchino

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 6939 - 6939

Опубликована: Апрель 8, 2023

The human body is vastly colonised by microorganisms, whose impact on health increasingly recognised. genital tract hosts a diverse microbiota, and an increasing number of studies the male microbiota suggest that bacteria have role in infertility pathological conditions, such as prostate cancer. Nevertheless, this research field remains understudied. study bacterial colonisation highly impacted invasive nature sampling low abundance microbiota. Therefore, most relied analysis semen to describe (MGT), which was thought be sterile. aim narrative review present results used next-generation sequencing (NGS) profile patterns different anatomical compartments critically highlight their findings weaknesses. Moreover, we identified potential axes may crucial for our understanding its pathophysiology.

Язык: Английский

Процитировано

28

Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway DOI Creative Commons

Yuhua Zhou,

Jing Lv,

Shengkai Jin

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 9, 2025

Prostate cancer was the fourth most diagnosed worldwide in 2022. Radical treatments and androgen deprivation therapy benefit newly patients but impact quality of life, often leading to castration-resistant prostate cancer. Short-term dietary changes significantly affect gut microbiota, which differs markedly between healthy individuals, impacting both progression treatment response. A high-choline diet increases risk fatal cancer, potentially mediated by conversion choline trimethylamine N-oxide (TMAO) microbiota. The CCK8 assay employed investigate whether TMAO affects proliferation ability cells determine appropriate drug concentration. Subsequently, time gradients, colony formation assays, EdU assays measured TMAO's influence on cell proliferation. Wound healing transwell migration evaluated effect migration. RNA-seq analysis performed explore mechanisms influences cells. qPCR Western blotting were utilized validate expression related mRNA or proteins. Finally, we vivo experiments evaluate a high growth subcutaneous tumors lung metastases mice. Our study found that enhances upregulating HMOX1 via activation MAPK signaling pathway, specifically p38 MAPK. In mouse tumor metastatic experiments, increased migration, resulting greater volume number than controls. This is first demonstrate role microbiota-derived metabolite promotes activating pathway increasing expression. Reducing intake through intervention may delay onset presenting significant clinical application value.

Язык: Английский

Процитировано

1

Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies DOI Creative Commons
Wenjuan Wang, Hong Wang, Qi Wang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 10, 2025

Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely terminal product but also nexus for initiating physiological pathological responses body. Lysine lactylation (Kla), novel post-translational modification (PTM) proteins, has emerged pivotal mechanism by which exerts regulatory influence. This epigenetic potential alter gene expression patterns, thereby impacting Increasing evidence indicates correlation between adverse prognosis various malignancies. Consequently, this review article aims encapsulate proteins interact with lactate, elucidate tumorigenesis progression, explore therapeutic targets afforded modulation lactylation. The objective is clarify oncogenic provide strategic framework future directions burgeoning field.

Язык: Английский

Процитировано

1

Accuracy of artificial intelligence in detecting tumor bone metastases: a systematic review and meta-analysis DOI Creative Commons

Huimin Tao,

Hui Xu, Zhi Hong Zhang

и другие.

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 18, 2025

Bone metastases (BM) represent a prevalent complication of tumors. Early and accurate diagnosis, however, is significant hurdle for radiologists. Recently, artificial intelligence (AI) has emerged as valuable tool to assist radiologists in the detection BM. This meta-analysis was undertaken evaluate AI diagnostic accuracy Two reviewers performed an exhaustive search several databases, including Wei Pu (VIP) database, China National Knowledge Infrastructure (CNKI), Web Science, Cochrane Library, Ovid-Embase, Ovid-Medline, Wan Fang Biology Medicine (CBM), from their inception December 2024. focused on studies that developed and/or validated techniques detecting BM magnetic resonance imaging (MRI) or computed tomography (CT). A hierarchical model used calculate odds ratio (DOR), negative likelihood (NLR), positive (PLR), area under curve (AUC), specificity (SP), pooled sensitivity (SE). The risk bias applicability were assessed using Prediction Model Risk Bias Assessment Tool (PROBAST), while Transparent Reporting multivariable prediction individual prognosis diagnosis-artificial (TRIPOD-AI) employed evaluating quality evidence. review covered 20 articles, among them, 16 included meta-analysis. results revealed SE 0.88 (0.82–0.92), SP 0.89 (0.84–0.93), AUC 0.95 (0.92–0.96), PLR 8.1 (5.57–11.80), NLR 0.14 (0.09–0.21) DOR 58 (31–109). When focusing algorithms. Based ML, (0.77–0.92), 0.93 (0.91–0.95). DL, (0.81–0.95), (0.81–0.94), (0.93–0.97). underscores substantial value identifying Nevertheless, in-depth large-scale prospective research should be carried out confirming AI's clinical utility management.

Язык: Английский

Процитировано

1

N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner DOI
Yibing Wang, Peng Jin, Xia Wang

и другие.

APOPTOSIS, Год журнала: 2023, Номер 29(1-2), С. 142 - 153

Опубликована: Сен. 12, 2023

Язык: Английский

Процитировано

22

Immune and inflammatory mechanisms and therapeutic targets of gout: An update DOI
Wenji Liu, Jie Peng, Yixin Wu

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 121, С. 110466 - 110466

Опубликована: Июнь 11, 2023

Язык: Английский

Процитировано

19

Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy DOI Creative Commons
Chen Ding, Jian‐Ge Wang, Jie Wang

и другие.

Translational Oncology, Год журнала: 2024, Номер 52, С. 102255 - 102255

Опубликована: Дек. 24, 2024

Язык: Английский

Процитировано

6

Sexual behavior shapes male genitourinary microbiome composition DOI Creative Commons
Evelyn Toh,

Yue Xing,

Xiang Gao

и другие.

Cell Reports Medicine, Год журнала: 2023, Номер 4(3), С. 100981 - 100981

Опубликована: Март 1, 2023

The origin, composition, and significance of the distal male urethral microbiome are unclear, but vaginal dysbiosis is linked to new sex partners several urogynecological syndromes. We characterized 110 specimens from men without symptoms, infections, or inflammation using shotgun metagenomics. Most contain characteristic lactic acid bacteria Corynebacterium spp. In contrast, associated with were present only in who reported intercourse. Sexual behavior, not other evaluated behavioral, demographic, clinical variables, strongly inter-specimen variance composition. Thus, urethra supports a simple core that established independent sexual exposures can be re-shaped by sex. Overall, results suggest urogenital microbiology behavior inexorably intertwined, show harbors female pathobionts.

Язык: Английский

Процитировано

15

Liposomes for the treatment of prostate cancer therapy: A review DOI Creative Commons

Chinmaya Keshari Sahoo,

Nalini Kanta Sahoo, Madhusmita Sahu

и другие.

Cancer Treatment and Research Communications, Год журнала: 2024, Номер 39, С. 100792 - 100792

Опубликована: Янв. 1, 2024

One of the cancers that affect men, prostate cancer considerably raises mortality rates for males around world. Patients with can have a localized or advanced form illness. Digital rectal examinations, prostate-specific antigen analyses, and biopsies are all used to identify cancer. The onset, development, spread correlated mutations in specific genes. Radical prostatectomy, ablative radiation, active surveillance forms treatment Androgen deprivation therapy (ADT), chemotherapy given men who metastatic experienced relapse. When compared traditional chemotherapeutic methods, liposome-based drug delivery technology offers less toxic, biodegradable, biocompatible nanomedicine. Liposomes offer great advantages use nanomedicines by improving sensitivity, specificity, persistence these anti-malignant cell agents body. Liposomal formulations undergoing clinical trials variety including present narrative review describes composition types liposomes, its advantages, disadvantages, methods preparation, research studies, applications, repurposing administration.

Язык: Английский

Процитировано

5