Small Methods,
Journal Year:
2023,
Volume and Issue:
8(8)
Published: Dec. 1, 2023
Immune
checkpoint
blockade
(ICB)
therapy
for
tumors
has
arisen
in
growing
interest.
However,
the
low
response
rate
of
to
ICB
is
mainly
attributed
inhibitory
infiltration
immune
cells
tumor
microenvironment
(TME).
Despite
promising
benefits
ICB,
therapeutic
effects
antibodies
are
dependent
on
a
high
dose
and
long-term
usage
clinic,
thereby
leading
immune-related
adverse
effects.
Accordingly,
combined
with
nano-delivery
systems
could
be
used
overcome
T
cell
exhaustion,
which
reduces
side
higher
rates
patients.
In
this
review,
authors
aim
exhaustion
TME
via
modulation
enhanced
immunotherapy.
Several
strategies
summarized
combine
further
enhance
immunotherapy:
a)
expressing
surface
systems;
b)
loading
inhibitors
into
c)
gene-editing
technology
d)
mediated
modulation.
Taken
together,
might
strategy
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(3), P. 483 - 483
Published: Jan. 25, 2023
Microbes
have
dominated
life
on
Earth
for
the
past
two
billion
years,
despite
facing
a
variety
of
obstacles.
In
20th
century,
antibiotics
and
immunizations
brought
about
these
changes.
Since
then,
microorganisms
acquired
resistance,
various
infectious
diseases
been
able
to
avoid
being
treated
with
traditionally
developed
vaccines.
Antibiotic
resistance
pathogenicity
surpassed
antibiotic
discovery
in
terms
importance
over
course
few
decades.
These
shifts
resulted
tremendous
economic
health
repercussions
across
board
all
socioeconomic
levels;
thus,
we
require
ground-breaking
innovations
effectively
manage
microbial
infections
provide
long-term
solutions.
The
pharmaceutical
biotechnology
sectors
radically
altered
as
result
nanomedicine,
this
trend
is
now
spreading
antibacterial
research
community.
Here,
examine
role
that
nanomedicine
plays
prevention
infections,
including
topics
such
diagnosis,
antimicrobial
therapy,
administration,
immunizations,
well
opportunities
challenges
lie
ahead.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(49)
Published: Aug. 24, 2024
Abstract
Immunoregulatory
strategies
for
activating
or
inhibiting
immune
responses
have
emerged
as
a
promising
approach
treating
tumors
and
immune‐related
inflammatory
diseases.
Nanomaterials,
also
known
their
inherent
immunoregulatory
capacity,
are
extensively
investigated
potential
in
immunotherapy.
Among
these
nanomaterials,
fullerene‐based
nanomaterials
with
unique
properties
attracted
considerable
attention
use
In
this
study,
comprehensive
review
of
the
recent
research
progress
on
is
presented.
It
illustrates
specific
mechanism
activation
using
fullerene
reviews
applications
tumor
immunotherapy
tumor‐enhancement
Now
introduces
molecular
over‐activated
inflammation.
Herein,
different
negative
developed
to
inhibit
Additionally,
current
challenges
prospects
developing
efficient
clinical
usage
discussed.
Small Methods,
Journal Year:
2023,
Volume and Issue:
8(8)
Published: Dec. 1, 2023
Immune
checkpoint
blockade
(ICB)
therapy
for
tumors
has
arisen
in
growing
interest.
However,
the
low
response
rate
of
to
ICB
is
mainly
attributed
inhibitory
infiltration
immune
cells
tumor
microenvironment
(TME).
Despite
promising
benefits
ICB,
therapeutic
effects
antibodies
are
dependent
on
a
high
dose
and
long-term
usage
clinic,
thereby
leading
immune-related
adverse
effects.
Accordingly,
combined
with
nano-delivery
systems
could
be
used
overcome
T
cell
exhaustion,
which
reduces
side
higher
rates
patients.
In
this
review,
authors
aim
exhaustion
TME
via
modulation
enhanced
immunotherapy.
Several
strategies
summarized
combine
further
enhance
immunotherapy:
a)
expressing
surface
systems;
b)
loading
inhibitors
into
c)
gene-editing
technology
d)
mediated
modulation.
Taken
together,
might
strategy
